SOD-like activity of Mn(II) β-octabromo-meso-tetrakis(N-methylpyridinium-3-yl)porphyrin equals that of the enzyme itself
Gilson DeFreitas-Silva,Júlio S. Rebouças,Ivan Spasojevic,Ludmil Benov,Ynara Marina Idemori,Ines Batinic-Haberle +5 more
TLDR
This work shows that exceptionally high k(cat) for the O2*- disproportionation can be achieved not only with an N(5)-type coordination motif, as rationalized previously for aza crown ether (cyclic polyamines) complexes, but also with a N(4)-type motif as in the Mn porphyrin case.About:
This article is published in Archives of Biochemistry and Biophysics.The article was published on 2008-09-01 and is currently open access. It has received 44 citations till now. The article focuses on the topics: Porphyrin.read more
Citations
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Journal ArticleDOI
Superoxide Dismutase Mimics: Chemistry, Pharmacology, and Therapeutic Potential
TL;DR: A comprehensive overview of the chemical properties and some in vivo effects observed with various classes of compounds with a special emphasis on porphyrin-based compounds is provided.
Journal ArticleDOI
Enzyme Mimics: Advances and Applications
TL;DR: This Review concerns the development of various types of enzyme mimics, namely polymeric and dendrimeric, supramolecular, nanoparticulate and proteinic enzyme mimICS, with an emphasis on their synthesis, catalytic properties and technical applications.
Journal ArticleDOI
SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathways
Ines Batinic-Haberle,Artak Tovmasyan,Emily R.H. Roberts,Zeljko Vujaskovic,Kam W. Leong,Ivan Spasojevic +5 more
TL;DR: The therapeutic and mechanistic relevance of oxidation of ascorbate and glutathionylation and oxidation of protein thiols by MnP-based SOD mimics and subsequent inactivation of nuclear factor κB has been substantiated in rescuing normal and killing cancer cells.
Journal ArticleDOI
Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities.
Ines Batinic-Haberle,Ivan Spasojevic,Hubert M. Tse,Artak Tovmasyan,Zrinka Rajić,Daret K. St. Clair,Zeljko Vujaskovic,Mark W. Dewhirst,Jon D. Piganelli +8 more
TL;DR: The most efficacious Mn(III) porphyrinic scavengers of reactive species have positive charges close to the Mn site, whereby they afford thermodynamic and electrostatic facilitation for the reaction with negatively charged species such as O2•− and ONOO− and the pro-oxidative action of MnPs in suppressing NF-κB activation in nucleus has been substantiated.
Journal ArticleDOI
Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP5+, via suppression of oxidative stress in a mouse model of breast tumor
Zahid N. Rabbani,Ivan Spasojevic,Xiuwu Zhang,Benjamin J. Moeller,Sinisa Haberle,Jeannette Vasquez-Vivar,Mark W. Dewhirst,Zeljko Vujaskovic,Ines Batinic-Haberle +8 more
TL;DR: This study indicates for the first time that MnTE-2-PyP(5+) has anti-cancer activity in its own right.
References
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Journal ArticleDOI
Superoxide Dismutase AN ENZYMIC FUNCTION FOR ERYTHROCUPREIN (HEMOCUPREIN)
Joe M. McCord,Irwin Fridovich +1 more
TL;DR: The demonstration that O2·- can reduce ferricytochrome c and tetranitromethane, and that superoxide dismutase, by competing for the superoxide radicals, can markedly inhibit these reactions, is demonstrated.
Journal ArticleDOI
Mutagenesis and stress responses induced in Escherichia coli by hydrogen peroxide
James A. Imlay,Stuart Linn +1 more
TL;DR: Analysis of the sensitivities of mutants that are deficient in individual SOS-regulated functions suggested that the SOS-mediated protection is due to the enhanced synthesis of recA protein, which is rate limiting for recombinational DNA repair.
Journal ArticleDOI
Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease
Mutay Aslan,Thomas M. Ryan,Brian Adler,Tim M. Townes,Dale A. Parks,J. Anthony Thompson,Albert Tousson,Mark T. Gladwin,Rakesh P. Patel,Margaret M. Tarpey,Ines Batinic-Haberle,C. Roger White,Bruce A. Freeman +12 more
TL;DR: Data reveal that episodes of intrahepatic hypoxia-reoxygenation associated with SCD can induce the release of XO into the circulation from the liver.
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The ortho effect makes manganese(III) meso-tetrakis(N-methylpyridinium-2-yl)porphyrin a powerful and potentially useful superoxide dismutase mimic.
TL;DR: The ortho, meta, andpara isomers of manganese(III) 5,10,15,20-tetrakis(N-methylpyridyl)porphyrin, Mn TM-2-PyP5+, MnTM-3-Py P5+, and MnTM -4- PyP5+ were analyzed in terms of their superoxide dismutase (SOD) activity in vitro and in vivo.
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Relationship among Redox Potentials, Proton Dissociation Constants of Pyrrolic Nitrogens, and in Vivo and in Vitro Superoxide Dismutating Activities of Manganese(III) and Iron(III) Water-Soluble Porphyrins
Ines Batinic-Haberle,Ivan Spasojevic,Peter Hambright,Ludmil Benov,and Alvin L. Crumbliss,Irwin Fridovich +5 more
TL;DR: The log kcat values for the dismutation of O2•- by a series of monohydroxoiron and aquamanganese porphyrins, including ortho, meta, and para isomers of 5,10,15,20-tetrakis(N-alkylpyridiniumyl)porphyrins), were found to vary linearly with the metal-centered redox potentials (E1/2) for the M(III