Book ChapterDOI
Sonophoresis: Ultrasound-Mediated Transdermal Drug Delivery
Samir Mitragotri
- pp 3-14
TLDR
This chapter provides an overview of the historical perspective, mechanisms, and applications of low-frequency ultrasound, which has been shown to enhance skin permeability to various small and large molecules including proteins.Abstract:
Transdermal drug delivery offers a patient-compliant mode of drug administration. Its applications, however, are limited to low-molecular-weight hydrophobic drugs. Application of ultrasound has been shown to enhance transdermal transport of drugs, a phenomenon known as sonophoresis. Ultrasound under various conditions has been used to perform sonophoresis. The use of low-frequency ultrasound (f < 100 kHz) is particularly effective in enhancing skin permeability. Low-frequency sonophoresis has been shown to enhance skin permeability to various small and large molecules including proteins. A device based on low-frequency ultrasound has also been approved for human use. This chapter provides an overview of the historical perspective, mechanisms, and applications of low-frequency ultrasound.read more
Citations
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Journal ArticleDOI
Formulation-based approaches for dermal delivery of vaccines and therapeutic nucleic acids: Recent advances and future perspectives.
TL;DR: The delivery platforms discussed in this review may provide formulation scientists and clinicians with a better vision of the alternatives for dermal delivery of biomacromolecules, which may facilitate the development of new patient‐friendly prophylactic and therapeutic medicines.
Book ChapterDOI
Cutaneous and Transdermal Drug Delivery: Techniques and Delivery Systems
TL;DR: In this article, the authors expound the skin as a barrier and things to know for transdermal research along with an exhaustive discussion on the factors affecting the design of Transdermal drug delivery systems.
Journal ArticleDOI
Investigating the Acoustic Response and Contrast Enhancement of Drug-Loadable PLGA Microparticles with Various Shapes and Morphologies.
TL;DR: It is found that multicavity PLGA microparticles respond to both therapeutic and diagnostic ultrasound and may be applied as a theranostic agent.
References
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Journal ArticleDOI
Current status and future potential of transdermal drug delivery
TL;DR: The already significant impact this field has made on the administration of various pharmaceuticals is discussed; limitations of the current technology are explored; methods under exploration for overcoming these limitations and the challenges ahead are discussed.
Journal ArticleDOI
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Journal ArticleDOI
Healing sound: the use of ultrasound in drug delivery and other therapeutic applications
TL;DR: Ultrasound, which is routinely used for diagnostic imaging applications, is now being adopted in various drug delivery and other therapeutic applications, and the principles and current status are reviewed.
Journal ArticleDOI
Ultrasound-mediated transdermal protein delivery.
TL;DR: Low-frequency ultrasound was shown to increase the permeability of human skin to many drugs, including high molecular weight proteins, by several orders of magnitude, thus making transdermal administration of these molecules potentially feasible.
Journal ArticleDOI
Experimental investigations of cavitation-bubble collapse in the neighbourhood of a solid boundary
W. Lauterborn,H. Bolle +1 more
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