Book ChapterDOI
Sonophoresis: Ultrasound-Mediated Transdermal Drug Delivery
Samir Mitragotri
- pp 3-14
TLDR
This chapter provides an overview of the historical perspective, mechanisms, and applications of low-frequency ultrasound, which has been shown to enhance skin permeability to various small and large molecules including proteins.Abstract:
Transdermal drug delivery offers a patient-compliant mode of drug administration. Its applications, however, are limited to low-molecular-weight hydrophobic drugs. Application of ultrasound has been shown to enhance transdermal transport of drugs, a phenomenon known as sonophoresis. Ultrasound under various conditions has been used to perform sonophoresis. The use of low-frequency ultrasound (f < 100 kHz) is particularly effective in enhancing skin permeability. Low-frequency sonophoresis has been shown to enhance skin permeability to various small and large molecules including proteins. A device based on low-frequency ultrasound has also been approved for human use. This chapter provides an overview of the historical perspective, mechanisms, and applications of low-frequency ultrasound.read more
Citations
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Journal ArticleDOI
Nano-Enhanced Drug Delivery and Therapeutic Ultrasound for Cancer Treatment and Beyond.
TL;DR: This review discusses the application of high intensity focus ultrasound for non-invasive tumor ablation and immunomodulatory effects of ultrasound, as well as the efficacy of nanoparticle-enhanced ultrasound therapies for different medical conditions.
Journal ArticleDOI
Combined use of nanocarriers and physical methods for percutaneous penetration enhancement.
TL;DR: This review describes combined use of frequently used nanocarriers with the most efficient physical methods (microneedles, iontophoresis, ultrasound and electroporation) and demonstrates superiority of the combined use and physical methods in drug penetration enhancement compared to their single use.
Journal ArticleDOI
Enhancing Permeation of Drug Molecules Across the Skin via Delivery in Nanocarriers: Novel Strategies for Effective Transdermal Applications.
TL;DR: In this paper, the skin structure and major obstacle for transdermal drug delivery, different nanocarriers, i.e., nanoparticles, ethosomes, dendrimers, liposomes, etc., have been discussed.
Journal ArticleDOI
Prospective Nanotechnology-Based Strategies for Enhanced Intra- and Transdermal Delivery of Antifungal Drugs.
TL;DR: Various approaches towards the stimulation of drug penetration through and into the stratum corneum and hair follicles, which are considered to be promising for the future improvement of superficial antifungal therapy as providing the drug localization and prolonged storage property at the targeted area are summarized.
Journal ArticleDOI
Transdermal Drug Delivery Using a Specialized Cavitation Seed for Ultrasound
Donghee Park,Jong Ho Won,Unchul Shin,Hyeon Jin Park,Gillsoo Song,Ji Young Jang,Hyunjin Park,Chul Woo Kim,Jong Bum Seo +8 more
TL;DR: Conclusively, sonophoresis with the proposed cavitation seed demonstrated the significant improvement in TDD and the possibility of macromolecule delivery into the skin.
References
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Journal ArticleDOI
Sonicated transdermal drug transport.
Amit Joshi,Jaideep Raje +1 more
TL;DR: The following review explores the promise shown by sonicated transdermal drug transport as a novel drug delivery system in great detail and elucidates the advantages of transderMAL drug transport (TDT) over the currently prevalent modes of drug administration.
Journal ArticleDOI
Topical delivery of anti-sense oligonucleotides using low-frequency sonophoresis.
TL;DR: These results show successful delivery of anti-sense oligonucleotides using low-frequency ultrasound, which led to the formation of localized transport pathways (LTPs) which occupied about 5% of the total exposed skin area.
Journal ArticleDOI
Analysis of ultrasonically extracted interstitial fluid as a predictor of blood glucose levels.
TL;DR: A potential method for noninvasive diagnostics based on ultrasonic skin permeabilization and subsequent extraction of interstitial fluid (ISF) across the skin using vacuum is presented.
Journal ArticleDOI
Ultrasound with Topical Anesthetic Rapidly Decreases Pain of Intravenous Cannulation
Bruce M. Becker,Sara Helfrich,Elizabeth Baker,Kirsten Lovgren,P. Allison Minugh,Jason T. Machan +5 more
TL;DR: It is demonstrated that ultrasound treatment followed by brief application of topical anesthetic decreases the patients' perception of the pain of IV cannulation in a randomized, controlled, prospective trial performed in a university hospital emergency department.
Journal ArticleDOI
High-Frequency Sonophoresis: Permeation Pathways and Structural Basis for Enhanced Permeability
TL;DR: Analysis of permeation pathways, and SC intercellular structural organization following applications of high-frequency sonophoresis to hairless mouse skin provides insights about the penetration pathways, permeabilizing mechanisms, and kinetics of sonphoresis on the epidermis.