Book ChapterDOI
Sonophoresis: Ultrasound-Mediated Transdermal Drug Delivery
Samir Mitragotri
- pp 3-14
TLDR
This chapter provides an overview of the historical perspective, mechanisms, and applications of low-frequency ultrasound, which has been shown to enhance skin permeability to various small and large molecules including proteins.Abstract:
Transdermal drug delivery offers a patient-compliant mode of drug administration. Its applications, however, are limited to low-molecular-weight hydrophobic drugs. Application of ultrasound has been shown to enhance transdermal transport of drugs, a phenomenon known as sonophoresis. Ultrasound under various conditions has been used to perform sonophoresis. The use of low-frequency ultrasound (f < 100 kHz) is particularly effective in enhancing skin permeability. Low-frequency sonophoresis has been shown to enhance skin permeability to various small and large molecules including proteins. A device based on low-frequency ultrasound has also been approved for human use. This chapter provides an overview of the historical perspective, mechanisms, and applications of low-frequency ultrasound.read more
Citations
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Journal ArticleDOI
Nano-Enhanced Drug Delivery and Therapeutic Ultrasound for Cancer Treatment and Beyond.
TL;DR: This review discusses the application of high intensity focus ultrasound for non-invasive tumor ablation and immunomodulatory effects of ultrasound, as well as the efficacy of nanoparticle-enhanced ultrasound therapies for different medical conditions.
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Combined use of nanocarriers and physical methods for percutaneous penetration enhancement.
TL;DR: This review describes combined use of frequently used nanocarriers with the most efficient physical methods (microneedles, iontophoresis, ultrasound and electroporation) and demonstrates superiority of the combined use and physical methods in drug penetration enhancement compared to their single use.
Journal ArticleDOI
Enhancing Permeation of Drug Molecules Across the Skin via Delivery in Nanocarriers: Novel Strategies for Effective Transdermal Applications.
TL;DR: In this paper, the skin structure and major obstacle for transdermal drug delivery, different nanocarriers, i.e., nanoparticles, ethosomes, dendrimers, liposomes, etc., have been discussed.
Journal ArticleDOI
Prospective Nanotechnology-Based Strategies for Enhanced Intra- and Transdermal Delivery of Antifungal Drugs.
TL;DR: Various approaches towards the stimulation of drug penetration through and into the stratum corneum and hair follicles, which are considered to be promising for the future improvement of superficial antifungal therapy as providing the drug localization and prolonged storage property at the targeted area are summarized.
Journal ArticleDOI
Transdermal Drug Delivery Using a Specialized Cavitation Seed for Ultrasound
Donghee Park,Jong Ho Won,Unchul Shin,Hyeon Jin Park,Gillsoo Song,Ji Young Jang,Hyunjin Park,Chul Woo Kim,Jong Bum Seo +8 more
TL;DR: Conclusively, sonophoresis with the proposed cavitation seed demonstrated the significant improvement in TDD and the possibility of macromolecule delivery into the skin.
References
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Journal ArticleDOI
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TL;DR: By relating the mechanical effects of these events on the stratum corneum structure, the relationship between the number of cavitation events and collapse pressures with experimentally measured increase in skin permeability was established.
Journal ArticleDOI
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TL;DR: The results demonstrate that exposure of the skin to ultrasound can induce the considerable and rapid facilitation of LH transport via an intercellular route, and pose further questions pertaining to the duration and reversibility of ultrasound action on skin.
Journal ArticleDOI
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TL;DR: Ultrasound treatment significantly increased the inhibition of cholinesterase during the first hour after application in both physostigmine treated rats and guinea pigs.
Journal ArticleDOI
Transcutaneous Immunization with Bacterial ADP-Ribosylating Exotoxins, Subunits, and Unrelated Adjuvants
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TL;DR: The results indicate that enhancement of the immune response to topical immunization is not restricted to CT or the ADP-ribosylating exotoxins as adjuvants, and reinforces earlier findings that addition of an adjuvant is important for the induction of robust immune responses to vaccine antigens delivered by topical application.