Book ChapterDOI
Sonophoresis: Ultrasound-Mediated Transdermal Drug Delivery
Samir Mitragotri
- pp 3-14
TLDR
This chapter provides an overview of the historical perspective, mechanisms, and applications of low-frequency ultrasound, which has been shown to enhance skin permeability to various small and large molecules including proteins.Abstract:
Transdermal drug delivery offers a patient-compliant mode of drug administration. Its applications, however, are limited to low-molecular-weight hydrophobic drugs. Application of ultrasound has been shown to enhance transdermal transport of drugs, a phenomenon known as sonophoresis. Ultrasound under various conditions has been used to perform sonophoresis. The use of low-frequency ultrasound (f < 100 kHz) is particularly effective in enhancing skin permeability. Low-frequency sonophoresis has been shown to enhance skin permeability to various small and large molecules including proteins. A device based on low-frequency ultrasound has also been approved for human use. This chapter provides an overview of the historical perspective, mechanisms, and applications of low-frequency ultrasound.read more
Citations
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Journal ArticleDOI
Nano-Enhanced Drug Delivery and Therapeutic Ultrasound for Cancer Treatment and Beyond.
TL;DR: This review discusses the application of high intensity focus ultrasound for non-invasive tumor ablation and immunomodulatory effects of ultrasound, as well as the efficacy of nanoparticle-enhanced ultrasound therapies for different medical conditions.
Journal ArticleDOI
Combined use of nanocarriers and physical methods for percutaneous penetration enhancement.
TL;DR: This review describes combined use of frequently used nanocarriers with the most efficient physical methods (microneedles, iontophoresis, ultrasound and electroporation) and demonstrates superiority of the combined use and physical methods in drug penetration enhancement compared to their single use.
Journal ArticleDOI
Enhancing Permeation of Drug Molecules Across the Skin via Delivery in Nanocarriers: Novel Strategies for Effective Transdermal Applications.
TL;DR: In this paper, the skin structure and major obstacle for transdermal drug delivery, different nanocarriers, i.e., nanoparticles, ethosomes, dendrimers, liposomes, etc., have been discussed.
Journal ArticleDOI
Prospective Nanotechnology-Based Strategies for Enhanced Intra- and Transdermal Delivery of Antifungal Drugs.
TL;DR: Various approaches towards the stimulation of drug penetration through and into the stratum corneum and hair follicles, which are considered to be promising for the future improvement of superficial antifungal therapy as providing the drug localization and prolonged storage property at the targeted area are summarized.
Journal ArticleDOI
Transdermal Drug Delivery Using a Specialized Cavitation Seed for Ultrasound
Donghee Park,Jong Ho Won,Unchul Shin,Hyeon Jin Park,Gillsoo Song,Ji Young Jang,Hyunjin Park,Chul Woo Kim,Jong Bum Seo +8 more
TL;DR: Conclusively, sonophoresis with the proposed cavitation seed demonstrated the significant improvement in TDD and the possibility of macromolecule delivery into the skin.
References
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Journal ArticleDOI
The Collapse of Cavitation Bubbles and the Pressures thereby Produced against Solid Boundaries
T. B. Benjamin,A. T. Ellis +1 more
TL;DR: A broad review of this subject as a branch of hydrodynamics is presented in this article, referring both to the well known ''implosion'' mechanism first analysed by Lord Rayleigh and, more particularly, to the recently perceived possibility that effects of equally great violence, such as to damage solid boundaries, may arise through the impact of liquid jets formed by collapsing cavities.
PatentDOI
Transdermal protein delivery using low-frequency sonophoresis
TL;DR: In this article, a method for simultaneous application of ultrasound and protein on the skin surface in order to deliver therapeutic doses of proteins across the skin was proposed, which can enhance transdermal transport of high-molecular weight proteins.
Journal ArticleDOI
Low-frequency sonophoresis: A review
Samir Mitragotri,Joseph Kost +1 more
TL;DR: Mechanistic insights gained through a number of investigations are also reviewed, and reports on the synergistic effect of low-frequency ultrasound with other enhancers including chemicals and iontophoresis are summarized.
Journal ArticleDOI
A Mechanistic Study of Ultrasonically‐Enhanced Transdermal Drug Delivery
TL;DR: It is suggested that among all the ultrasound-related phenomena evaluated, cavitation plays the dominant role in sonophoresis using therapeutic ultrasound, and a theoretical model is developed to predict the effect of ultrasound on the transdermal transport of drugs.
Journal ArticleDOI
Ultrasound-mediated transdermal drug delivery: mechanisms, scope, and emerging trends.
TL;DR: The use of ultrasound for the delivery of drugs to, or through, the skin is commonly known as sonophoresis or phonophoreis as mentioned in this paper, and the mechanisms associated with each physical enhancer are different.