Journal ArticleDOI
Stability of the interface between neural tissue and chronically implanted intracortical microelectrodes
Xindong Liu,Douglas B. McCreery,R.R. Carter,Leo A. Bullara,Ted G. H. Yuen,William F. Agnew +5 more
- Vol. 7, Iss: 3, pp 315-326
TLDR
The results indicate that, after implantation, the electrode-tissue interface may change from day-to-day over the first 1-2 weeks, week- to-week for 1- 2 months, and become quite stable thereafter, and a stability index is proposed to quantify the stability of the electrodes-tissues interface.Abstract:
The stability of the interface between neural tissue and chronically implanted microelectrodes is very important for obtaining reliable control signals for neuroprosthetic devices. Stability is also crucial for chronic microstimulation of the cerebral cortex. However, changes of the electrode-tissue interface can be caused by a variety of mechanisms. In the present study, intracortical microelectrode arrays were implanted into the pericruciate gyrus of cats and neural activities were recorded on a regular basis for several months. An algorithm based on cluster analysis and interspike interval analysis was developed to sort the extracellular action potentials into single units. We tracked these units based on their waveform and their response to somatic stimulation or stereotypical movements by the cats. Our results indicate that, after implantation, the electrode-tissue interface may change from day-to-day over the first 1-2 weeks, week-to-week for 1-2 months, and become quite stable thereafter. A stability index is proposed to quantify the stability of the electrode-tissue interface. The reasons for the pattern of changes are discussed.read more
Citations
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Journal ArticleDOI
Brain-computer interfaces for communication and control.
Jonathan R. Wolpaw,Jonathan R. Wolpaw,Niels Birbaumer,Niels Birbaumer,Dennis J. McFarland,Gert Pfurtscheller,Theresa M. Vaughan +6 more
TL;DR: With adequate recognition and effective engagement of all issues, BCI systems could eventually provide an important new communication and control option for those with motor disabilities and might also give those without disabilities a supplementary control channel or a control channel useful in special circumstances.
Journal ArticleDOI
Brain-computer interfaces for communication and control
TL;DR: The brain's electrical signals enable people without muscle control to physically interact with the world through the use of their brains' electrical signals.
Journal ArticleDOI
Brain-computer interface technology: a review of the first international meeting
Jonathan R. Wolpaw,Niels Birbaumer,W.J. Heetderks,Dennis J. McFarland,Paul Hunter Peckham,Gerwin Schalk,Emanuel Donchin,L.A. Quatrano,C.J. Robinson,C.J. Robinson,Theresa M. Vaughan +10 more
TL;DR: The first international meeting devoted to brain-computer interface research and development is summarized, which focuses on the development of appropriate applications, identification of appropriate user groups, and careful attention to the needs and desires of individual users.
Journal ArticleDOI
Electrical stimulation of excitable tissue: design of efficacious and safe protocols.
TL;DR: The physical basis for electrical stimulation of excitable tissue, as used by electrophysiological researchers and clinicians in functional electrical stimulation, is presented with emphasis on the fundamental mechanisms of charge injection at the electrode/tissue interface.
Journal ArticleDOI
Response of brain tissue to chronically implanted neural electrodes.
TL;DR: This review presents the biological components and time course of the acute and chronic tissue reaction in brain tissue, analyses the brain tissue response of current electrode systems, and comments on the various material science and bioactive strategies undertaken by electrode designers to enhance electrode performance.
References
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Book
Cluster Analysis
TL;DR: This fourth edition of the highly successful Cluster Analysis represents a thorough revision of the third edition and covers new and developing areas such as classification likelihood and neural networks for clustering.
Journal ArticleDOI
Axonal sprouting accompanies functional reorganization in adult cat striate cortex.
TL;DR: It is reported here that structural changes in the form of axonal sprouting of long-range laterally projecting neurons accompany topographic remodelling of the visual cortex.
Journal ArticleDOI
Automatic sorting of multiple unit neuronal signals in the presence of anisotropic and non-Gaussian variability.
TL;DR: A procedure to efficiently sort spikes in the presence of noise that is anisotropic, i.e., dominated by particular frequencies, and whose amplitude distribution may be non-Gaussian, such as occurs when spike waveforms are a function of interspike interval is presented.