Journal ArticleDOI
Steroid biosynthesis by cultures of normal human adrenal tissue.
T. Jones,M. Groom,K. Griffiths +2 more
TLDR
DHA and DHA sulphate were produced mainly by the reticular tissue and there was a marked stimulation of their synthesis in this tissue under the influence of ACTH.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 1970-01-23. It has received 20 citations till now. The article focuses on the topics: Steroid biosynthesis & Reticular connective tissue.read more
Citations
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Journal ArticleDOI
The zona reticularis is the site of biosynthesis of dehydroepiandrosterone and dehydroepiandrosterone sulfate in the adult human adrenal cortex resulting from its low expression of 3 beta-hydroxysteroid dehydrogenase
TL;DR: The most likely cause of the age-related decline in adrenal androgen biosynthesis is an age- related decline in the number of functional reticularis cells, without a major change in the differentiated properties of the zonal cells as a function of age.
Journal ArticleDOI
Control of secretion and the function of C19-Δ5-steroids of the human adrenal gland
TL;DR: This volume will certainly clarify and expand the reader’s knowledge of this vast subject and satisfy the thirst of the researcher, but rather stimulate his imagination and incite him to new achievements.
Journal ArticleDOI
Biosynthesis of DHEAS by the Human Adrenal Cortex and Its Age‐Related Decline
TL;DR: The aim of this review is to account for the high rate of synthesis of DHEA(S) by the young adult adrenal gland at a cellular and molecular level, to examine the basis for the differences between humans and nonprimate species in DHEAs biosynthesis, and to offer some ideas for the mechanism of the age-rclatcd decline in secretion.
Journal ArticleDOI
Control of circadian and episodic variations of adrenal androgens secretion in man
TL;DR: In this paper, the 24-hour profiles of plasma cortisol (F), 11-β-hydroxyandrostenedione (11OHAD), androstenedion (AD), dehydroisoandrosterone (DHEA) and testosterone (T) were obtained simultaneously in 11 normal males sampled at 15-min intervals.
Book ChapterDOI
The regulation of adrenocortical function by control of growth and structure
TL;DR: The adrenal cortex exhibits a unique system of physiological regulation, incorporating three separately regulated systems of hormone synthesis—mineralocorticoid, glucocortioid, and androgen—into the life history of a single cell type.
References
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Journal ArticleDOI
The culture of mature organs in a synthetic medium.
TL;DR: The survival of brain, liver, thymus, spleen, bone marrow, testis and pancreas was unsatisfactory and partial survival was obtained in the case of kidney, adrenal and spinal ganglion.
Journal ArticleDOI
Hydrolysis of ketosteroid hydrogen sulfates by solvolysis procedures.
Journal ArticleDOI
Arenal cells in tissue culture. I. Assay of steroid products; steroidogenic responses to peptide hormones.
J. Kowal,R. Fiedler +1 more
TL;DR: These cells provide a viable and highly reproducible system for the in vitro study of ACTH action and a fluorometric assay has been developed that permits precise quantitation of steroid output within several minutes' incubation.
Journal ArticleDOI
A biochemical investigation of the functional zonation of the adrenal cortex in man.
TL;DR: The zones of human adrenal cortices have been separated by slicing and their chemical composition and steroid biosynthetic activity in vitro examined and theories of the functional zonation of the adrenal cortex in man are discussed.
Related Papers (5)
A biochemical investigation of the functional zonation of the adrenal cortex in man.
Steroidogenic Enzyme Activities in Cultured Human Definitive Zone Adrenocortical Cells: Comparison with Bovine Adrenocortical Cells and Resultant Differences in Adrenal Androgen Synthesis
Peter J. Hornsby,Kathy A. Aldern +1 more