Streptococcus pneumoniae colonization after introduction of 13-valent pneumococcal conjugate vaccine for US adults 65 years of age and older, 2015-2016.
Jennifer Milucky,Maria de Gloria Carvalho,Nadine Rouphael,Nancy M. Bennett,H. Keipp Talbot,Lee H. Harrison,Monica M. Farley,Monica M. Farley,Jeremy D. Walston,Fabiana Cristina Pimenta,Fernanda C. Lessa,Mary Bower,Nina N. McNair,Nina N. McNair,Sabrina R Williams,Emily Presmanes,Amy Tunali,Stephanie Thomas,Rosemary Hollick,Jacqueline M. Langdon,Amir Salar Sepehri,Anna Sharova +21 more
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TLDR
Pneumococcal carriage among non-institutionalized adults ≥65 years of age was very low, and given the low vaccine-type carriage rates observed in an already high PCV13 adult coverage setting, it is difficult to attribute the findings to the direct versus indirect effects ofPCV13 on adult carriage.About:
This article is published in Vaccine.The article was published on 2019-01-23 and is currently open access. It has received 21 citations till now. The article focuses on the topics: Pneumococcal conjugate vaccine & Quellung reaction.read more
Citations
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The fundamental link between pneumococcal carriage and disease
TL;DR: The use of vaccine effect on carriage as part of the vaccine licensure and post-vaccine introduction evaluation could facilitate and expand the licensure of new, life-saving pneumococcal vaccines and enable a comprehensive estimate of population effects after vaccine introduction.
Journal ArticleDOI
Upper respiratory tract colonization with Streptococcus pneumoniae in adults
Adriano Arguedas,Krzysztof Trzciński,Katherine L. O'Brien,Daniela M. Ferreira,Anne L. Wyllie,Daniel M. Weinberger,Leon Danon,Stephen I. Pelton,Chiara Azzari,Laura L. Hammitt,Raquel Sá-Leão,Maria Cristina de Cunto Brandileone,Samir K. Saha,Jose A Suaya,Raul E Isturiz,Luis Jodar,Bradford D Gessner +16 more
TL;DR: Plymouthococcal carriage studies in adults that collect samples from alternative respiratory sites such as the oropharynx, saliva, or nasal wash; are culture-enriched for pneumococcus; and use molecular diagnostic methods designed to target two pneumococcal DNA sequences should enhance pneumitiscal detection in the adult respiratory tract are found.
Journal ArticleDOI
Nasopharyngeal carriage of Streptococcus pneumoniae, Haemophilus influenzae, and Staphylococcus aureus in a Brazilian elderly cohort.
Rosemeire Cobo Zanella,Maria Cristina de Cunto Brandileone,Samanta Cristine Grassi Almeida,Ana Paula Silva de Lemos,Claudio Tavares Sacchi,Cláudia Regina Gonçalves,Maria Gisele Gonçalves,Lucila Okuyama Fukasawa,Marcos Daniel Saraiva,Luís Fernando Rangel,Julia Lusis Lassance Cunha,Thereza Cristina Ariza Rotta,Christian Douradinho,Wilson Jacob-Filho,Ruth Minamisava,Ana Lucia Andrade +15 more
TL;DR: It is found that a higher S. aureus carriage rate compared with the S. pneumoniae- and H. influenzae-carriage rates in a well-attended population in a geriatric outpatient clinic can support future colonization studies among elderly individuals.
Journal ArticleDOI
The low carriage prevalence of pneumococcus among community-dwelling older people: A cross-sectional study in Japan
Ikkoh Yasuda,Motoi Suzuki,Bhim Gopal Dhoubhadel,Mayumi Terada,Akira Satoh,Eiichiro Sando,Tomoko Hiraoka,Masaki Kurihara,Nobuo Matsusaka,Fumitaka Kawahara,Koya Ariyoshi,Konosuke Morimoto +11 more
TL;DR: The data suggest a low carriage prevalence of S. pneumoniae among community-dwelling older people in Japan, and among the pneumococcal-positive participants, 18.2% were PCV13-covered serotypes.
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Nonpneumococcal Strains Recently Recovered from Carriage Specimens and Expressing Capsular Serotypes Highly Related or Identical to Pneumococcal Serotypes 2, 4, 9A, 13, and 23A.
Robert E. Gertz,Fabiana Cristina Pimenta,Sopio Chochua,Shanda Larson,Anne-Kathryn L. Venero,Godfrey Bigogo,Jennifer Milucky,Maria da Gloria Carvalho,Bernard Beall +8 more
TL;DR: In this article, the authors describe 9 nonpneumococcal strains carrying close homologs of pneumococcal capsular biosynthetic (cps) loci that were discovered during recent pneumoccal carriage studies of adults in the United States and Kenya.
References
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Journal ArticleDOI
The Human Oral Microbiome
Floyd E. Dewhirst,Floyd E. Dewhirst,Tuste Chen,Jacques Izard,Jacques Izard,Bruce J. Paster,Bruce J. Paster,Anne C.R. Tanner,Anne C.R. Tanner,Wen-Han Yu,Abirami Lakshmanan,William G. Wade,William G. Wade +12 more
TL;DR: The HOMD is the first curated description of a human-associated microbiome and provides tools for use in understanding the role of the microbiome in health and disease.
Journal ArticleDOI
Community-acquired pneumonia requiring hospitalization among U.S. adults
Seema Jain,Derek J. Williams,Sandra R. Arnold,Krow Ampofo,Anna M. Bramley,Carrie Reed,Chris Stockmann,Evan J. Anderson,Carlos G. Grijalva,Wesley H. Self,Yuwei Zhu,Anami Patel,Weston Hymas,James D. Chappell,Robert A. Kaufman,J. Herman Kan,David Dansie,Noel Lenny,David R. Hillyard,Lia M. Haynes,Min Z. Levine,Stephen Lindstrom,Jonas M. Winchell,Jacqueline M. Katz,Dean D. Erdman,Eileen Schneider,Lauri A. Hicks,Richard G. Wunderink,Kathryn M. Edwards,Andrew T. Pavia,Jonathan A. McCullers,Lyn Finelli +31 more
TL;DR: The incidence of community-acquired pneumonia requiring hospitalization was highest among the oldest adults and despite current diagnostic tests, no pathogen was detected in the majority of patients.
Journal ArticleDOI
Sustained Reductions in Invasive Pneumococcal Disease in the Era of Conjugate Vaccine
Tamara Pilishvili,Catherine Lexau,Monica M. Farley,Monica M. Farley,James L. Hadler,Lee H. Harrison,Nancy M. Bennett,Arthur Reingold,Ann Thomas,William Schaffner,Allen S. Craig,Philip J. Smith,Bernard Beall,Cynthia G. Whitney,Matthew R. Moore +14 more
TL;DR: Dramatic reductions in IPD after PCV7 introduction in the United States remain evident 7 years later, and IPD rates caused by serotype 19A and other non-PCV7 types have increased but remain low relative to decreases in PCV 7-type IPD.
Journal ArticleDOI
Polysaccharide Conjugate Vaccine against Pneumococcal Pneumonia in Adults
Marc J. M. Bonten,Susanne M. Huijts,Marieke Bolkenbaas,Chris Webber,Scott Patterson,Samantha Gault,Cornelis H. van Werkhoven,Anna M M van Deursen,Elisabeth A. M. Sanders,Theo J M Verheij,Michael Patton,Anne McDonough,Anita Moradoghli-Haftvani,Helen M Smith,Tracey Mellelieu,Michael W. Pride,Graham Crowther,Beate Schmoele-Thoma,Daniel A. Scott,Kathrin U. Jansen,Rita Lobatto,Bas J. Oosterman,Nils Visser,Esther Caspers,Andre J. Smorenburg,Emilio A. Emini,William C. Gruber,Diederick E. Grobbee +27 more
TL;DR: Among older adults, PCV13 was effective in preventing vaccine-type pneumococcal, bacteremic, and noninvasive community-acquired pneumonia and vaccine- type invasive pneumococCal disease but not in preventing community- Acquired pneumonia from any cause.
Journal ArticleDOI
Effect of use of 13-valent pneumococcal conjugate vaccine in children on invasive pneumococcal disease in children and adults in the USA: Analysis of multisite, population-based surveillance
Matthew R. Moore,Ruth Link-Gelles,William Schaffner,Ruth Lynfield,Catherine Lexau,Nancy M. Bennett,Susan Petit,Shelley M. Zansky,Lee H. Harrison,Arthur Reingold,Lisa Miller,Karen Scherzinger,Ann Thomas,Monica M. Farley,Monica M. Farley,Elizabeth R. Zell,Thomas H. Taylor,Tracy Pondo,Loren Rodgers,Lesley McGee,Bernard Beall,James H. Jorgensen,Cynthia G. Whitney +22 more
TL;DR: PCV13 reduced IPD across all age groups when used routinely in children in the USA, providing reassurance that, similar to PCV7, PCVs with additional serotypes can also prevent transmission to unvaccinated populations.
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