Structure and promoter analysis of the gene encoding the human melanoma-inhibiting protein MIA.
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TLDR
The structure of the human MIA gene locus is reported, its expression pattern in melanocytic tumors in vivo is described, and an initial characterization of the MIA promoter is provided.About:
This article is published in Journal of Biological Chemistry.The article was published on 1996-01-05 and is currently open access. It has received 96 citations till now. The article focuses on the topics: Melanoma inhibitory activity & Regulation of gene expression.read more
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Journal ArticleDOI
Loss of E-cadherin Expression in Melanoma Cells Involves Up-regulation of the Transcriptional Repressor Snail
Ina Poser,David Domı́nguez,Antonio García de Herreros,Alinda Varnai,Reinhard Buettner,Anja K. Bosserhoff +5 more
TL;DR: It is concluded that activation of Snail expression plays an important role in down-regulation of E-cadherin and tumorigenesis of malignant melanomas.
Journal Article
Melanoma-inhibiting activity, a novel serum marker for progression of malignant melanoma.
Anja-Katrin Bosserhoff,Martin Kaufmann,Brigitte Kaluza,Ilse Bartke,H. Zirngibl,Rüdiger Hein,Wilhelm Stolz,Reinhard Buettner +7 more
TL;DR: Enhanced MIA serum levels are reported in 13 and 23% of patients with stage I and II disease, respectively, and in 100% with stage III or IV disease, revealing the highest sensitivity and specificity among currently available markers.
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S100-Beta, Melanoma-Inhibiting Activity, and Lactate Dehydrogenase Discriminate Progressive From Nonprogressive American Joint Committee on Cancer Stage IV Melanoma
Martin Deichmann,Axel Benner,Michael Bock,Andreas Jäckel,Karen Uhl,Volker Waldmann,Helmut Näher +6 more
TL;DR: Elevated serum levels of S100beta, MIA, and LDH indicate current disease progression in AJCC stage IV melanoma, andLDH was the most relevant overall parameter.
Journal ArticleDOI
A novel MCP-1 gene polymorphism is associated with hepatic MCP-1 expression and severity of HCV-related liver disease.
Marcus Mühlbauer,Anja K. Bosserhoff,Arndt Hartmann,Wolfgang E. Thasler,Thomas S. Weiss,Hans H Herfarth,Guntram Lock,Jürgen Schölmerich,Claus Hellerbrand +8 more
TL;DR: In Inheritance of the -2518 MCP-1 G allele, which appears to affect hepatic M CP-1 expression, may predispose HCV patients to more severe hepatic inflammation and fibrosis.
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Molecular diagnostics in melanoma
J. Andrew Carlson,J.S. Ross,J.S. Ross,Andrzej Slominski,Gerald P. Linette,Judith Mysliborski,Jerome Hill,Martin C. Mihm +7 more
TL;DR: In this paper, molecular diagnostics that can potentially benefit the individual melanoma patient are discussed, which may aid in melanoma identification, prognostication, and detection of minimal residual disease/early recurrence.
References
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Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing.
TL;DR: A method is described for the rapid generation and cloning of deletion derivatives well-suited for the sequencing of long stretches of DNA based on two useful features of exonuclease III: processive digestion at a very uniform rate and failure to initiate digestion at DNA ends with four-base 3'-protrusions.
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CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements
Bruno Luckow,Günther Schütz +1 more
TL;DR: In the promoterless construction pBLCAT3 eight unique restriction sites are suitable for insertion of different eukaryotic promoters at the 5' end of the CAT gene, enabling the excision of the intact fusion gene from the prokaryotic vector.
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NF-κB: A pleiotropic mediator of inducible and tissue-specific gene control
TL;DR: Comment intervient le NF-kB, quels sont les systemes dans lesquels il joue un role, tels que les messages intracellulaires, l'activation des cellules C, the regulation of the cytokinine, ou encore l'utilisation par les virus
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Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor.
Yutaka Kawakami,Siona Eliyahu,Cynthia H. Delgado,Paul F. Robbins,Licia Rivoltini,Suzanne L. Topalian,Toru Miki,Steven A. Rosenberg +7 more
TL;DR: A gene encoding a melanocyte lineage-specific protein (MART-1) that is a widely shared melanoma antigen recognized by the T lymphocytes of patients with established malignancy is identified and opens possibilities for the development of immunotherapies for patients with melanoma.
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Site-directed mutagenesis of virtually any plasmid by eliminating a unique site.
Win Ping Deng,Jac A. Nickoloff +1 more
TL;DR: Since most plasmids share common vector sequences, few primers, targeted to shared restriction sites, are needed for mutagenizing virtually any plasmid, and the procedure can be performed in as little as 2 days.