Journal ArticleDOI
Studies on the nature of the cholinergic receptor.
TLDR
The ability of p -chloro-mercuribenzoate and of dithioerythritol to inhibit the cholinergic receptor favors the view that a protein is a part of the receptor structure.About:
This article is published in European Journal of Pharmacology.The article was published on 1968-08-01. It has received 61 citations till now. The article focuses on the topics: Muscarinic acetylcholine receptor M5 & Protease-activated receptor 2.read more
Citations
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BookDOI
The Peripheral Nervous System
TL;DR: This chapter discusses Neuromuscular Transmission-The Transmitter-Receptor Combination, which focuses on the role of the Nerve Impulse in the synthesis, storage, and release of Acetylcholine.
Journal ArticleDOI
Multiple forms of acetylcholinesterase and their distribution in endplate and non-endplate regions of rat diaphragm muscle.
TL;DR: Although the activity of all three forms of acetylcholinesterase were decreased in denervated muscle, the largest proportional decrease occurred in theActivity of the 16 S form, which may correspond to the endplate enzyme.
Journal ArticleDOI
STUDIES OF EXCITABLE MEMBRANES: I. Macromolecular Specializations of the Neuromuscular Junction and the Nonjunctional Sarcolemma
John E. Rash,Mark H. Ellisman +1 more
TL;DR: Evidence is assembled which indicates that these large transmembrane macromolecules may represent the morphological correlate for functional acetylcholine receptor activity in mammalian motor endplates.
Journal ArticleDOI
Effects of proteolytic enzymes on function and structure of frog neuromuscular junctions
William J. Betz,Bert Sakmann +1 more
TL;DR: Frog cutaneous pectoris nerve‐muscle preparations were incubated with collagenase and protease and examined with electrophysiological and electron microscopic techniques.
Journal ArticleDOI
Lest I Forget Thee, Glutathione …
TL;DR: This review of the present situation of glutathione ends with some suggestions for the future.
References
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Journal ArticleDOI
Allosteric Proteins and Cellular Control Systems
TL;DR: The biological activity of many proteins is controlled by specific metabolites which do not interact directly with the substrates or products of the reactions, and it is suggested that this mechanism plays an essential role in the regulation of metabolic activity.
Journal ArticleDOI
A histochemical method for localizing cholinesterase activity.
TL;DR: A histochemical method is presented for localizing ChE activity by incubating tissue sections in a medium containing acetylthiocholine, copper glycinate and copper thiocholine with results obtained with several tissues containing specific ChE.
Journal ArticleDOI
A study of supersensitivity in denervated mammalian skeletal muscle.
J. Axelsson,Stephen Thesleff +1 more
Journal ArticleDOI
On the application of "a plausible model" of allosteric proteins to the receptor for acetylcholine.
TL;DR: The application of the allosteric model of Monod, Wyman & Changeux (1965) to the receptor for acetylcholine results in a description which accounts for observed slopes of the Hill plot of the response greater than 1 and provides criteria for differentiating allosterics and competitive inhibitors.
Journal ArticleDOI
Effects of blocking sulfhydryl groups and of reducing disulfide bonds on the acetylcholine-activated permeability system of the electroplax.
Arthur Karlin,Eva Bartels +1 more
TL;DR: Evidence is taken as support for the view that some of the components of the acetylcholine-activated permeability system at the junctional regions of the innervated membrane of the electroplax are proteins.
Related Papers (5)
Effects of blocking sulfhydryl groups and of reducing disulfide bonds on the acetylcholine-activated permeability system of the electroplax.
Arthur Karlin,Eva Bartels +1 more
Enzymatic Detachment of Endplate Acetylcholinesterase from Muscle
Zach W. Hall,Regis B. Kelly +1 more