Supplementation with vitamin D in the COVID-19 pandemic?
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TLDR
The postulated mechanisms and clinical data supporting the protective role of vitamin’D against COVID-19–mediated complications are discussed and epidemiologic studies of the relationship between vitamin D and various respiratory infections were reviewed.Abstract:
The coronavirus disease 2019 (COVID-19) pandemic was declared a public health emergency of international concern by the World Health Organization. COVID-19 has high transmissibility and could result in acute lung injury in a fraction of patients. By counterbalancing the activity of the renin-angiotensin system, angiotensin-converting enzyme 2, which is the fusion receptor of the virus, plays a protective role against the development of complications of this viral infection. Vitamin D can induce the expression of angiotensin-converting enzyme 2 and regulate the immune system through different mechanisms. Epidemiologic studies of the relationship between vitamin D and various respiratory infections were reviewed and, here, the postulated mechanisms and clinical data supporting the protective role of vitamin D against COVID-19-mediated complications are discussed.read more
Citations
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Current State of Evidence: Influence of Nutritional and Nutrigenetic Factors on Immunity in the COVID-19 Pandemic Framework.
TL;DR: In this article, an update on the evidence of the contribution of nutritional factors as immune-enhancing aspects, factors that could reduce their bioavailability, and the role of the optimal status of these nutrients within the COVID-19 pandemic context was carried out.
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Therapeutics for COVID-19 and post COVID-19 complications: An update
TL;DR: In this paper , a consolidated summary of the therapeutic developments against SARS-CoV-2 is presented along with an overview of effective management of post COVID-19 complications.
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COVID-19 in Joint Ageing and Osteoarthritis: Current Status and Perspectives
TL;DR: It is hypothesize that SARS-CoV-2 contributes to age-related perturbations in endothelial and adipose tissue, which are known to characterize the early aging process, which would explain the long-lasting symptoms of Sars-Cov-2 as the result of an accelerated aging process.
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Vitamin D and Sex Differences in COVID-19.
TL;DR: In COVID-19 the inter-individual variability in circulating levels of 25-hydroxyvitamin D (25(OH)D), the biomarker of vitamin D status could be involved in the different severity of pulmonary inflammation and viral pathogenicity among individuals.
Journal ArticleDOI
Notable Developments for Vitamin D Amid the COVID-19 Pandemic, but Caution Warranted Overall: A Narrative Review.
TL;DR: In this paper, the general status of nutraceuticals and dietary supplements amid the SARS-CoV-2 pandemic is appraised, with a particular focus on vitamin D. Overall, poor vitamin D status seems to be associated with an increased risk of COVID-19.
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