Synthesis and anti-bacterial properties of mono-carbonyl analogues of curcumin.
Guang Liang,Guang Liang,Shulin Yang,Lijuan Jiang,Yu Zhao,Lili Shao,Jian Xiao,Faqing Ye,Yueru Li,Xiaokun Li,Xiaokun Li +10 more
Reads0
Chats0
TLDR
It was observed that part of the derivatives displayed significant activity when compared with curcumin and most of them exhibited activity against the ampicillin-resisted Enterobacter cloacae.Abstract:
The synthesis of three series of curcumin analogues with mono-carbonyl is described. Their in vitro anti-bacterial activities against seven Gram-positive and Gram-negative bacteria were tested and the effect of substituents on the aryl ring and the space structure of the linking strain were discussed. It was observed that part of the derivatives displayed significant activity when compared with curcumin and most of them exhibited activity against the ampicillin-resisted Enterobacter cloacae. Compounds A12, B09, B13, B14 and C09 show remarkable antibacterial activity in vitro. The result showed that heterocycle or long-chain substituents may enhance the activity of curcumin analogues.read more
Citations
More filters
Journal ArticleDOI
Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature.
Preetha Anand,Sherin G. Thomas,Ajaikumar B. Kunnumakkara,Chitra Sundaram,Kuzhuvelil B. Harikumar,Bokyung Sung,Sheeja T. Tharakan,Krishna Misra,Indira K. Priyadarsini,Kallikat N. Rajasekharan,Bharat B. Aggarwal +10 more
TL;DR: This review focuses on the status of all these approaches in generating a "super curcumin," a homodimer of feruloylmethane containing a methoxy group and a hydroxyl group, a heptadiene with two Michael acceptors, and an alpha,beta-diketone.
Journal ArticleDOI
Bactericidal activity of curcumin I is associated with damaging of bacterial membrane.
TL;DR: The present study confirms the broad-spectrum antibacterial nature of curcumin I, and its membrane damaging property, and could provide impetus for further research on cur cumin I regarding its antibiotic potential against rapidly emerging bacterial pathogens.
Journal ArticleDOI
Exploration and synthesis of curcumin analogues with improved structural stability both in vitro and in vivo as cytotoxic agents.
Guang Liang,Lili Shao,Yi Wang,Chengguang Zhao,Yanhui Chu,Jian Xiao,Yu Zhao,Xiaokun Li,Xiaokun Li,Shulin Yang +9 more
TL;DR: The results suggest that the five-carbon linker-containing analogues of curcumin may be favorable for theCurcumin-based drug development both pharmacokinetically and pharmacologically.
Journal ArticleDOI
Curcumin and its analogues: potential anticancer agents.
TL;DR: Few analogues of curcumin have shown very potent results and may be considered as clinical candidates for the development of future anticancer agent.
Journal ArticleDOI
Curcumin inhibits glyoxalase 1: a possible link to its anti-inflammatory and anti-tumor activity.
Thore Santel,Gabi Pflug,Nasr Y. A. Hemdan,Nasr Y. A. Hemdan,Nasr Y. A. Hemdan,Angelika Schäfer,Marcus Hollenbach,Martin Buchold,Anja Hintersdorf,Inge Lindner,Andreas Otto,Marina Bigl,Ilka Oerlecke,Antje Hutschenreuter,Ulrich Sack,Ulrich Sack,Klaus Huse,Marco Groth,Marco Groth,Claudia Birkemeyer,Wolfgang Schellenberger,Rolf Gebhardt,Mathias Platzer,Thomas S. Weiss,Mookambeswaran A. Vijayalakshmi,Monika Krüger,Gerd Birkenmeier +26 more
TL;DR: Results indicate that inhibition of Glo1 by curcumin may result in non-tolerable levels of MGO and GSH, which, in turn, modulate various metabolic cellular pathways including depletion of cellular ATP and G SH content.
References
More filters
Journal ArticleDOI
Pharmacology of Curcuma longa
TL;DR: It appears that when given orally, curcumin is far less active than after i.p. administration, and systemic effects seem to be questionable after oral application except that they occur at very low concentrations ofCurcumin, which does not exclude a local action in the gastrointestinal tract.
Journal ArticleDOI
Multiple biological activities of curcumin: a short review.
TL;DR: This review summarizes the most interesting in vitro and in vivo studies on the biological effects of curcumin, the constituent of turmeric, which has been widely studied for its anti-inflammatory, anti-angiogenic,Anti-oxidant, wound healing and anti-cancer effects.
Journal Article
Chemopreventive Effect of Curcumin, a Naturally Occurring Anti-Inflammatory Agent, during the Promotion/Progression Stages of Colon Cancer
Toshihiko Kawamori,Ronald A. Lubet,Vernon E. Steele,Gary J. Kelloff,Robert B. Kaskey,Chinthalapally V. Rao,Bandaru S. Reddy +6 more
TL;DR: Administration of curcumin to the rats during the initiation and postinitiation stages and throughout the promotion/progression stage increased apoptosis in the colon tumors as compared to colon tumors in the groups receiving AOM and the control diet.
Journal ArticleDOI
Antibacterial activity of turmeric oil: a byproduct from curcumin manufacture.
TL;DR: In this article, turmeric oleoresin was extracted from the mother liquor using hexane at 60 degrees C, and the hexane extract was separated into three fractions using silica gel column chromatography.
Book ChapterDOI
Pharmacokinetics and pharmacodynamics of curcumin
TL;DR: Curcumin's ability to alter gene transcription and induce apoptosis in preclinical models advocates its potential utility in cancer chemoprevention and chemotherapy.