Synthesis and antioxidant study of new polyphenolic hybrid-coumarins
Karina Pérez-Cruz,Mauricio Moncada-Basualto,Mauricio Moncada-Basualto,Javier Morales-Valenzuela,Germán Barriga-González,P.A. Navarrete-Encina,L. J. Nuñez-Vergara,Juan A. Squella,Claudio Olea-Azar +8 more
TLDR
In this paper, the antioxidant capacity of hydroxylated coumarins and hydroxybenzoic acids was evaluated against reactive oxygen species (ROS) using oxygen radical absorbance capacity-fluorescein (ORAC-FL), electron spin resonance (ESR) spin trapping, quenching of superoxide anion, cellular antioxidant activity (CAA), and a ferric reducing ability of plasma (FRAP assay).About:
This article is published in Arabian Journal of Chemistry.The article was published on 2017-05-17 and is currently open access. It has received 57 citations till now. The article focuses on the topics: Ferric reducing ability of plasma & Hydroxybenzoic acid.read more
Citations
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Journal ArticleDOI
Recent Advances in the Synthesis of Coumarin Derivatives from Different Starting Materials.
TL;DR: This review summarized various methods, techniques and reaction conditions for synthesis of coumarins from different compounds such as aldehydes, phenols, ketones and carboxylic acids.
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Rational approaches, design strategies, structure activity relationship and mechanistic insights for therapeutic coumarin hybrids.
Harbinder Singh,Jatinder Vir Singh,Kavita Bhagat,Harmandeep Kaur Gulati,Mohit Sanduja,Nitish Kumar,Nihar Kinarivala,Sahil Sharma,Sahil Sharma +8 more
TL;DR: This review summarizes the recent development (2014 and onwards) of these pharmacologically active coumarin hybrids and demonstrates rationale behind their design, structure-activity relationships (SAR) and mechanistic studies performed on these hybrid molecules.
Journal ArticleDOI
Design, Synthesis, Antimicrobial Evaluation, and Molecular Modeling Studies of Novel Indolinedione-Coumarin Molecular Hybrids.
Kavita Bhagat,Jyoti Bhagat,Manish K. Gupta,Jatinder Vir Singh,Harmandeep Kaur Gulati,Atamjit Singh,Kamalpreet Kaur,Gurinder Kaur,Shally Sharma,Abhineet Rana,Harbinder Singh,Sahil Sharma,Preet Mohinder Singh Bedi +12 more
TL;DR: Compounds K-1 and K-2 were found to be the best antimicrobial agents with the minimum inhibitory concentration values of 30 and 312 μg/mL, against Penicillium sp.
Journal ArticleDOI
Coumarins in Food and Methods of Their Determination.
Mirjana Lončar,Martina Jakovljević,Drago Šubarić,Martina Pavlić,Vlatka Buzjak Služek,Ines Cindrić,Maja Molnar +6 more
TL;DR: The overview of the current European regulations on coumarin levels in food is presented, along with the most common cou marin food sources, with a special emphasis on cinnamon-containing food.
Journal ArticleDOI
Monocarbonyl Curcumin-Based Molecular Hybrids as Potent Antibacterial Agents.
Atamjit Singh,Jatinder Vir Singh,Abhineet Rana,Kavita Bhagat,Harmandeep Kaur Gulati,Raman Kumar,Rajan Salwan,Kajal Bhagat,Gurinder Kaur,Navjot Singh,Randeep Kumar,Harbinder Singh,Sahil Sharma,Preet Mohinder Singh Bedi +13 more
TL;DR: In this paper, triazole-tethered monocarbonyl curcumin-coumarin and isatin molecular hybrids have been synthesized and evaluated for their antibacterial potential against Gram-positive (Enterococcus faecalis and Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa and Escherichia coli) human pathogenic bacterial strains.
References
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The ferric reducing ability of plasma (FRAP) as a measure of 'antioxidant power' : the FRAP assay
TL;DR: The FRAP assay offers a putative index of antioxidant, or reducing, potential of biological fluids within the technological reach of every laboratory and researcher interested in oxidative stress and its effects.
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Free radicals and antioxidants in normal physiological functions and human disease
TL;DR: Attention is focussed on the ROS/RNS-linked pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases, rheumatoid arthritis, and ageing.
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Structure-antioxidant activity relationships of flavonoids and phenolic acids
TL;DR: The factors underlying the influence of the different classes of polyphenols in enhancing their resistance to oxidation are discussed and support the contention that the partition coefficients of the flavonoids as well as their rates of reaction with the relevant radicals define the antioxidant activities in the lipophilic phase.
Journal ArticleDOI
Self‐consistent molecular orbital methods. XXIII. A polarization‐type basis set for second‐row elements
Michelle Francl,William J. Pietro,Warren J. Hehre,J. Stephen Binkley,Mark S. Gordon,Douglas J. DeFrees,John A. Pople +6 more
TL;DR: In this article, the 631G* and 6 31G* basis sets were extended through the second-row of the periodic table and the Hartree-Fock wave functions were used to obtain the equilibrium geometries for one-heavy-atom hydrides.
Book
Vogel's Textbook of Practical Organic Chemistry
Arthur I. Vogel,Brian S. Furniss +1 more
TL;DR: In this paper, the authors present a method for the synthesis of organic compounds using Spectroscopic methods and Spectral Spectral Methods (SSTM) with a focus on alicyclic and aliphatic compounds.