Journal ArticleDOI
Synthesis, characterization, and antibacterial activity of a novel heterocyclic Schiff’s base and its metal complexes of first transition series
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In this article, the synthesis of a series of novel Schiff base complexes with tetradentate base has been achieved by the reaction of malonyl hydrazide with dehydroacetic acid in ethanol under refluxing condition.Abstract:
The synthesis of a series of some novel Schiff base complexes of Cu(II), Ni(II), Co(II), Mn(II), Zn(II) with a tetradentate Schiff base has been achieved by the reaction of malonyl hydrazide with dehydroacetic acid in ethanol under refluxing condition. All the synthesized metal complexes and ligand were characterized on the basis of elemental analysis, UV–Visible, 1H and 13C NMR, IR spectroscopy and mass spectrometry. The IR spectral data suggest that azomethine N and enolic O atom are involved in coordination with metal ions, and the ligand behaves as a tetradentate ligand with ONNO donor atoms. The mass spectrum of the complexes reveals the formation of metal ligand bonding in stoichiometric ratio 1:1 (M:L). The UV–Visible data suggest the square planner geometry for the synthesized complexes. All compounds were screened for their antibacterial activity against gram-positive and gram-negative bacteria using Ampicillin as a standard drug. It has been found that metal complexes show enhanced activity as compared to ligand, and some modification in ligand structure may lead to better antibacterial agents in future.read more
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A review: Pharmacological aspects of metal based 1,2,4-triazole derived Schiff bases
TL;DR: A review of metal-based 1,2,4-triazole derived Schiff base compounds is presented in this paper, where metal chelates acting as an intermediate between conventional organic and inorganic compounds provided innovative opportunities in the field of pharmaceutical chemistry.
Journal ArticleDOI
DNA binding and cleavage, cytotoxicity and antimicrobial studies of Co(II), Ni(II), Cu(II) and Zn(II) complexes of 1-((E)-(4-(trifluoromethoxy)phenylimino)methyl)naphthalen-2-ol Schiff base
TL;DR: Four mononuclear complexes with a Schiff base ligand along with ligand have been screened for antimicrobial activity against bacterial species Bacillus amyloliquefaciens and Escherichia coli as well as fungal species Macrophomina phaseolina and Sclerotium rolfsii, and it is found that all complexes are more potent than free ligand.
Journal ArticleDOI
Antibacterial Evaluation and Virtual Screening of New Thiazolyl-Triazole Schiff Bases as Potential DNA-Gyrase Inhibitors.
Cristina Nastasă,Dan Cristian Vodnar,Ioana Ionuţ,Anca Stana,Daniela Benedec,Radu Tamaian,Ovidiu Oniga,Brînduşa Tiperciuc +7 more
TL;DR: The virtual screening concluded that thiazolyl-triazole Schiff base B8 is the best drug-like candidate, satisfying requirements for both safety and efficacy, being more potent against the bacterial gyrA than ciprofloxacin.
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Mononuclear Co(II), Ni(II) and Cu(II) complexes of the Schiff base, 2-(((4-trifluoromethoxy)phenylimino)methyl)-6-tert-butylphenol: Synthesis, spectroscopic characterization, X-ray study and biological evaluation
TL;DR: In this paper, three mononuclear binary complexes with Schiff base ligand, HL 2-((E)-(4-trifluoromethoxy)phenylimino)methyl)-6-tert-butylphenol, C18H18F3NO2) were synthesized and characterized by elemental analysis, ESI mass, FT-IR, ESR, UV-visible, magnetic susceptibility, thermogravimetry and single crystal X-ray diffraction studies.
Journal ArticleDOI
Structural characterization, thermal investigation and biological activity of metal complexes containing Schiff Base ligand (Z)‐3‐(1‐((4,6‐dimethyl‐1H‐pyrazolo[3,4‐b] pyridin‐3‐yl)imino)ethyl)‐4‐hydroxy‐6‐methyl‐2H‐pyran‐2‐one
References
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