Journal ArticleDOI
Synthesis of chalcones and flavanones using Julia–Kocienski olefination
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TLDR
A new application of Julia-Kocienski olefination for the synthesis of chalcones and flavanones has been described in this article, where 2-(Benzo[d]thiazol-2-ylsulfonyl)-1-(2-hydroxyphenyl)ethanone reacted with the aromatic aldehydes to furnish flavanone in good yields via one-pot intra-molecular cyclization.About:
This article is published in Tetrahedron.The article was published on 2010-11-27. It has received 73 citations till now. The article focuses on the topics: Julia olefination & Flavanone.read more
Citations
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Chalcone: A Privileged Structure in Medicinal Chemistry.
TL;DR: This review aims to highlight the recent evidence of chalcone as a privileged scaffold in medicinal chemistry and is expected to be a comprehensive, authoritative, and critical review of the chal cone template to the chemistry community.
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Chalcone scaffolds as anti-infective agents: Structural and molecular target perspectives
TL;DR: A comprehensive study of the structural features of anti-infective chalcones, their mechanism of actions (MOAs) and structure activity relationships (SARs) have been highlighted and may be helpful for (medicinal) chemists to design more potent, safe, selective and cost effective anti- Infective agents.
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Chalcone synthesis, properties and medicinal applications: a review
Aluru Rammohan,Aluru Rammohan,Julakanti Satyanarayana Reddy,G. Sravya,Chittluri Narasimha Rao,Grigory V. Zyryanov,Grigory V. Zyryanov +6 more
TL;DR: In this article, the synthesis of chalcones and their biological activities with focus on structure-activity relationships are discussed, and the properties, biosynthesis and structural diversity of natural chalcone are reviewed.
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Potential pharmacological uses of chalcones: a patent review (from June 2011 – 2014)
TL;DR: The review emphasizes the rationale behind the natural sources, the discovery, the design, the synthesis, the biological activities and the study of structure–activity relationships of the new chalcone derivatives.
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Promising anti-inflammatory effects of chalcones via inhibition of cyclooxygenase, prostaglandin E2, inducible NO synthase and nuclear factor κb activities.
TL;DR: This review focuses on the anti-inflammatory effects of chalcones, caused by their inhibitory action primarily against the activities and expressions of four key inflammatory mediators viz., cyclooxygenase, prostaglandin E2, inducible NO synthase, and nuclear factor κB.
References
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The Wittig olefination reaction and modifications involving phosphoryl-stabilized carbanions. Stereochemistry, mechanism, and selected synthetic aspects
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The Utility of Phosphonate Carbanions in Olefin Synthesis
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