TAFII250-independent Transcription Can Be Conferred on a TAFII250-dependent Basal Promoter by Upstream Activators
TLDR
It is shown that the basal promoter of a major histocompatibility complex class I gene requires TAFII250, and the presence of the 72-base pair enhancer overcomes this requirement.About:
This article is published in Journal of Biological Chemistry.The article was published on 2000-04-07 and is currently open access. It has received 23 citations till now. The article focuses on the topics: Response element & Upstream activating sequence.read more
Citations
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Journal ArticleDOI
Activator-Specific Recruitment of TFIID and Regulation of Ribosomal Protein Genes in Yeast
TL;DR: These results demonstrate activator-specific recruitment of TFIID in vivo, and they suggest that TFIIDs recruitment is important for coordinate expression of RP genes.
Journal ArticleDOI
Transcriptional Coactivator, CIITA, Is an Acetyltransferase that Bypasses a Promoter Requirement for TAFII250
Aparna Raval,T. Kevin Howcroft,Jocelyn D. Weissman,Susan Kirshner,Xin Sheng Zhu,Kazunari Yokoyama,Jenny P.-Y. Ting,Dinah S. Singer +7 more
TL;DR: CIITA contains an intrinsic acetyltransferase activity that maps to a region within the N-terminal segment of CIITA, between amino acids 94 and 132, that activates the promoter in the absence of functional TAF(II)250.
Journal ArticleDOI
Epigenetic control of MHC-II: interplay between CIITA and histone-modifying enzymes.
Eleni Zika,Jenny P.-Y. Ting +1 more
TL;DR: Mounting evidence suggests that the class II transactivator modulates promoter accessibility by coordinating the recruitment of chromatin modifiers in a time-dependent fashion, and MHC-II expression is exquisitely controlled by these highly specific, coordinated and dynamic interactions at the promoter.
Journal ArticleDOI
CIITA and Its Dual Roles in MHC Gene Transcription
TL;DR: A complex picture of the mechanisms regulating CIITA function is emerging suggesting thatCIITA has dual roles in transcriptional regulation which are summarized in this review.
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Major Histocompatibility Class II Transactivator (CIITA) Mediates Repression of Collagen (COL1A2) Transcription by Interferon γ (IFN-γ)
TL;DR: The data suggest that CIITA is a crucial member of a repressor complex responsible for mediating COL1A2 transcription repression by IFN-γ.
References
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Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
TL;DR: A procedure for preparing extracts from nuclei of human tissue culture cells that directs accurate transcription initiation in vitro from class II promoters, including tRNA and Ad 2 VA, is developed.
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Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.
TL;DR: A series of recombinant genomes which directed expression of the enzyme chloramphenicol acetyltransferase (CAT) in mammalian cells provided a uniquely convenient system for monitoring the expression of foreign DNAs in tissue culture cells.
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The general transcription factors of RNA polymerase II.
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Binding of TAFs to core elements directs promoter selectivity by RNA polymerase II
TL;DR: It is suggested that TAFs play a critical role in promoter selectivity and transcription regulation through direct contacts with core promoter elements in directing basal promoter function.
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TBP-associated factors are not generally required for transcriptional activation in yeast
TL;DR: TAF depletion in yeast cells can reduce transcription from some promoters lacking conventional TATA elements, and TAT depletion has surprisingly little effect on transcriptional enhancement by several activators, indicating that TAFs are not generally required for transcriptional activation in yeast.