A subset of TAF(II)s are integral components of the SAGA complex required for nucleosome acetylation and transcriptional stimulation.
Patrick A. Grant,Patrick A. Grant,David Schieltz,Marilyn G. Pray-Grant,Marilyn G. Pray-Grant,David J. Steger,David J. Steger,Joseph C. Reese,John R. Yates,Jerry L. Workman,Jerry L. Workman +10 more
TLDR
A role for certain TAF(II) proteins in the regulation of gene expression at the level of chromatin modification that is distinct from the TFIID complex and TAF (II)145 is illustrated.About:
This article is published in Cell.The article was published on 1998-07-10 and is currently open access. It has received 417 citations till now. The article focuses on the topics: SAGA complex & Histone acetyltransferase.read more
Citations
More filters
Journal ArticleDOI
The coregulator exchange in transcriptional functions of nuclear receptors
TL;DR: Based on their importance in biology and medicine, as well as the relatively simple mechanism of regulation, NR represent one of the most intensively studied and best-understood classes of transcription factors at the molecular level.
PatentDOI
Dissecting the regulatory circuitry of a eukaryotic genome
TL;DR: The results reveal an unanticipated level of regulation which is superimposed on that due to gene-specific transcription factors, a novel mechanism for coordinate regulation of specific sets of genes when cells encounter limiting nutrients, and evidence that the ultimate targets of signal transduction pathways can be identified within the initiation apparatus.
Journal ArticleDOI
Nuclear receptor coregulators: cellular and molecular biology.
TL;DR: This review will summarize selected aspects of the current knowledge of the cellular and molecular biology of nuclear receptor coregulators.
Journal ArticleDOI
Acetylation of Histones and Transcription-Related Factors
TL;DR: This work detail these known factor acetyltransferase (FAT) substrates and the demonstrated or potential roles of their acetylation in transcriptional processes.
Journal ArticleDOI
Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms.
Mark Eben Massari,Cornelis Murre +1 more
TL;DR: The helix-loop-helix (HLH) family of transcriptional regulatory proteins are key players in a wide array of developmental processes, including neurogenesis, myogenesis, hematopoiesis, and pancreatic development and the structure and functional properties are examined.
References
More filters
Journal ArticleDOI
Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide Gels
TL;DR: Silver staining allows a substantial shortening of sample preparation time and may, therefore, be preferable over Coomassie staining, and this work removes a major obstacle to the low-level sequence analysis of proteins separated on polyacrylamide gels.
Journal ArticleDOI
An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database.
TL;DR: The approach described in this manuscript provides a convenient method to interpret tandem mass spectra with known sequences in a protein database.
Journal ArticleDOI
Histone acetylation and transcriptional regulatory mechanisms
TL;DR: Understanding of the causal relationship between histone acetylation and gene expression has been enhanced dramatically by the identification of proteins with intrinsic hist one acetylase and deacetylase activity, which led to a major paradigm shift in understanding of chromatin structure and transcription regulation.
Journal ArticleDOI
Tetrahymena Histone Acetyltransferase A: A Homolog to Yeast Gcn5p Linking Histone Acetylation to Gene Activation
J. E. Brownell,J. Zhou,Tamara A. Ranalli,R. Kobayashi,Diane G. Edmondson,S. Y. Roth,C. D. Allis +6 more
TL;DR: These findings shed light on the biochemical function of the evolutionarily conserved Gcn5p-Ada complex, directly linking histone acetylation to gene activation, and indicate that histoneacetylation is a targeted phenomenon.
Journal ArticleDOI
Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex.
Patrick A. Grant,Laura J. Duggan,Jacques Côté,S M Roberts,James E. Brownell,Reyes Candau,Reiko Ohba,Tom Owen-Hughes,C D Allis,Fred Winston,Shelley L. Berger,Jerry L. Workman +11 more
TL;DR: The function of Gcn5 as a hist one acetyltransferase within the Ada and SAGA adaptor complexes indicates the importance of histone acetylation during steps in transcription activation mediated by interactions with transcription activators and general transcription factors.