Targeting microbial biofilms: current and prospective therapeutic strategies.
TLDR
This Review focuses on current therapeutic strategies and those under development that target vital structural and functional traits of microbial biofilms and drug tolerance mechanisms, including the extracellular matrix and dormant cells.Abstract:
Biofilm formation is a key virulence factor for a wide range of microorganisms that cause chronic infections. The multifactorial nature of biofilm development and drug tolerance imposes great challenges for the use of conventional antimicrobials and indicates the need for multi-targeted or combinatorial therapies. In this Review, we focus on current therapeutic strategies and those under development that target vital structural and functional traits of microbial biofilms and drug tolerance mechanisms, including the extracellular matrix and dormant cells. We emphasize strategies that are supported by in vivo or ex vivo studies, highlight emerging biofilm-targeting technologies and provide a rationale for multi-targeted therapies aimed at disrupting the complex biofilm microenvironment.read more
Citations
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Journal ArticleDOI
The oral microbiota: dynamic communities and host interactions.
TL;DR: Current knowledge and emerging mechanisms governing oral polymicrobial synergy and dysbiosis that have both enhanced the understanding of pathogenic mechanisms and aided the design of innovative therapeutic approaches for oral diseases are discussed.
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Biofilm Matrixome: Extracellular Components in Structured Microbial Communities
TL;DR: It is emphasized that targeting biofilm-specific conditions such as the matrixome could lead to precise and effective antibiofilm approaches, and the need for more in-depth analyses of the EPS matrix in mixed communities that are associated with many human infectious diseases is discussed.
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Nanomaterial-based therapeutics for antibiotic-resistant bacterial infections
Jessa Marie Makabenta,Ahmed Nabawy,Cheng-Hsuan Li,Suzannah M. Schmidt-Malan,Robin Patel,Vincent M. Rotello +5 more
TL;DR: The mechanisms by which nanomaterials can be used to target antibiotic-resistant bacterial infections are discussed, design elements and properties of nanomMaterials that can be engineered to enhance potency are highlighted, and recent progress and remaining challenges for clinical implementation are explored.
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Nanotechnology-based antimicrobials and delivery systems for biofilm-infection control.
Yong Liu,Yong Liu,Linqi Shi,Linzhu Su,Henny C. van der Mei,Paul C Jutte,Yijin Ren,Henk J. Busscher +7 more
TL;DR: The requirements and merits of nanotechnology-based antimicrobials for the control of biofilm-infection form the focus of this Tutorial Review.
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Metal‐Based Nanomaterials in Biomedical Applications: Antimicrobial Activity and Cytotoxicity Aspects
Pooyan Makvandi,Pooyan Makvandi,Pooyan Makvandi,Chen yu Wang,Ehsan Nazarzadeh Zare,Assunta Borzacchiello,Li Na Niu,Li Na Niu,Franklin R. Tay +8 more
TL;DR: An overview on the state‐of‐the‐art antimicrobial nanosized metal‐based compounds is provided, including metal and metal oxide nanoparticles as well as transition metal nanosheets, and their biomedical applications such as catheters, implants, medical delivery systems, tissue engineering, and dentistry.
References
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The biofilm matrix
TL;DR: The functions, properties and constituents of the EPS matrix that make biofilms the most successful forms of life on earth are described.
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Bacterial biofilms: from the natural environment to infectious diseases.
TL;DR: It is evident that biofilm formation is an ancient and integral component of the prokaryotic life cycle, and is a key factor for survival in diverse environments.
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Biofilms: an emergent form of bacterial life.
Hans-Curt Flemming,Jost Wingender,Ulrich Szewzyk,Peter D. Steinberg,Scott A. Rice,Staffan Kjelleberg +5 more
TL;DR: The fundamental role of the biofilm matrix is considered, describing how the characteristic features of biofilms — such as social cooperation, resource capture and enhanced survival of exposure to antimicrobials — all rely on the structural and functional properties of the matrix.
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Virus interference. I The interferon
Alick Isaacs,Jean Lindenmann +1 more
TL;DR: During a study of the interference produced by heat-inactivated influenza virus with the growth of live virus in fragments of chick chorio-allantoic membrane it was found that following incubation of heated virus with membrane a new factor was released.
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Antimicrobial activity of metals: mechanisms, molecular targets and applications
TL;DR: The chemical and toxicological principles that underlie the antimicrobial activity of metals are described and the preferences of metal atoms for specific microbial targets are discussed.