The abdominal constriction response and its suppression by analgesic drugs in the mouse
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This article is published in British journal of pharmacology and chemotherapy.The article was published on 1968-02-01 and is currently open access. It has received 1243 citations till now. The article focuses on the topics: Analgesic.read more
Citations
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Journal Article
Animal Models of Nociception
TL;DR: It is concluded that although the neural basis of the most used tests is poorly understood, their use will be more profitable if pain is considered within, rather than apart from, the body's homeostatic mechanisms.
Journal ArticleDOI
Formalin test in mice, a useful technique for evaluating mild analgesics.
TL;DR: The results indicate that the formalin test is useful for evaluating mild analgesics and may have advantages over some of the tests that are commonly used for testing analgesics.
Journal ArticleDOI
Involvement of resident macrophages and mast cells in the writhing nociceptive response induced by zymosan and acetic acid in mice
Ronaldo A. Ribeiro,Mariana Lima Vale,Sara M. Thomazzi,Adriana Balbina Paoliello Paschoalato,Steve Poole,S. H. Ferreira,Fernando Q. Cunha +6 more
TL;DR: The results suggest that the nociceptive activity of zymosan and acetic acid in the writhing model is due to the release of TNF-alpha, interleukin 1beta and interleucin 8 by resident peritoneal macrophages and mast cells.
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Hypernociceptive role of cytokines and chemokines: targets for analgesic drug development?
Waldiceu A. Verri,Thiago M. Cunha,Carlos Amílcar Parada,Stephen Poole,Fernando Q. Cunha,Sérgio H. Ferreira +5 more
TL;DR: The evidence suggesting pro- and anti-inflammatory cytokines and chemokines are potential targets to develop novel drugs and therapies for the treatment of pain is emphasized, emphasizing the importance of the direct and indirect actions of cytokine actions in inflammatory and neuropathic hypernociception.
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An electronic pressure-meter nociception paw test for mice
Thiago M. Cunha,Waldiceu A. Verri,G.G. Vivancos,I.F. Moreira,S. Reis,Carlos Amílcar Parada,Fernando Q. Cunha,S H Ferreira +7 more
TL;DR: The results show that the electronic pressure-meter provides a sensitive, objective and quantitative mechanical nociceptive test that could be useful to characterize new nOCiceptive inflammatory mediators and also to evaluate new peripheral analgesic substances.
References
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The use of changes in capillary permeability in mice to distinguish between narcotic and nonnarcotic analgesics
TL;DR: An extension of the "squirming test" is described which makes the method specific for nonnarcotic analgesics, and shows that drugs that stimulate the central nervous system and also inhibit squirming have no significant effect on leakage of dye over the range of doses which inhibit squirmed.
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A method for evaluating both non-narcotic and narcotic analgesics.
TL;DR: A simple method has been designed for evaluating both non-narcotic and narcotic analgesics based upon the specific antagonism of analgesics to the typical “syndrome” produced by intra-peritoneal injection of 2-phenyl-1,4-benzo-quinone in mice.
Journal Article
Antagonism of the frequency of phenylquinone-induced writhing in the mouse by weak analgesics and nonanalgesics
L. C. Hendershot,Janet Forsaith +1 more
TL;DR: The frequency of writhing motions in mice given phenylquinone intraperitoneally can be altered by low doses of Na acetylsalicylate and other low potency analgesic agents.
Book
Substances producing pain and itch
TL;DR: This book is a comprehensive and well documented review of current knowledge about chemical substances capable of producing pain and/or itch.
Related Papers (5)
The formalin test in mice: dissociation between inflammatory and non-inflammatory pain
Steinar Hunskaar,Kjell Hole +1 more