The Association of Arsenic Metabolism with Cancer, Cardiovascular Disease, and Diabetes: A Systematic Review of the Epidemiological Evidence
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The available evidence on the role of arsenic metabolism in individual susceptibility to the development of cancer, cardiovascular disease, and diabetes has not been formally and compre... as discussed by the authors, however, the role has not yet been formally evaluated.Abstract:
Background: The available evidence on the role of arsenic metabolism in individual susceptibility to the development of cancer, cardiovascular disease, and diabetes has not been formally and compre...read more
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Heavy metal associated health hazards: An interplay of oxidative stress and signal transduction.
Jagdish Gopal Paithankar,Sanjay Saini,Shiwangi Dwivedi,Anurag Sharma,Debapratim Kar Chowdhuri +4 more
TL;DR: An effort has been made to decipher the interplay among heavy metals/metalloids exposures, oxidative stress, and signal transduction, which are essential to mount the cellular and organismal response.
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Exosomal circRNA_100284 from arsenite-transformed cells, via microRNA-217 regulation of EZH2, is involved in the malignant transformation of human hepatic cells by accelerating the cell cycle and promoting cell proliferation.
Xiangyu Dai,Chao Chen,Qianlei Yang,Junchao Xue,Xiong Chen,Baofei Sun,Fei Luo,Xinlu Liu,Tian Xiao,Hui Xu,Qian Sun,Aihua Zhang,Qizhan Liu +12 more
TL;DR: The results showed that circRNA_100284 is involved in the malignant transformation of L-02 cells induced by arsenite, and the concept that exosomal circRNAs are involved in cell–cell communication during carcinogenesis induced by arsenalite is supported.
Journal ArticleDOI
Association of Low-Moderate Arsenic Exposure and Arsenic Metabolism with Incident Diabetes and Insulin Resistance in the Strong Heart Family Study
Maria Grau-Perez,Chin-Chi Kuo,Matthew O. Gribble,Poojitha Balakrishnan,Miranda Spratlen,Dhananjay Vaidya,Kevin A. Francesconi,Walter Goessler,Eliseo Guallar,Ellen K. Silbergeld,Jason G. Umans,Jason G. Umans,Lyle G. Best,Elisa T. Lee,Barbara V. Howard,Barbara V. Howard,Shelley A. Cole,Ana Navas-Acien +17 more
TL;DR: Among participants without baseline prediabetes, arsenic exposure was associated with incident diabetes and the association of arsenic metabolism with HOMA2-IR differed by B-vitamin intake and AS3MT genetics variants.
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Exo-circRNAs: a new paradigm for anticancer therapy.
TL;DR: This work presents a comprehensive update of the promising role of exo-circRNAs in anticancer therapy and describes the biogenesis, characteristics, and functions of circRNAs and exosomes.
References
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The Statistical Analysis of Compositional Data
TL;DR: In this article, the authors present an approach to perform compositional analysis of geochemical compositions of rocks using logratio linear models and a combination of matrix covariance analysis and linear linear models.