Journal ArticleDOI
The chemokine system in diverse forms of macrophage activation and polarization.
Alberto Mantovani,Alberto Mantovani,Antonio Sica,Silvano Sozzani,Silvano Sozzani,Paola Allavena,Annunciata Vecchi,Massimo Locati +7 more
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TLDR
Recent evidence suggests that differential modulation of the chemokine system integrates polarized macrophages in pathways of resistance to, or promotion of, microbial pathogens and tumors, or immunoregulation, tissue repair and remodeling.About:
This article is published in Trends in Immunology.The article was published on 2004-12-01. It has received 5568 citations till now. The article focuses on the topics: Macrophage polarization & M2 Macrophage.read more
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Nanoparticles Targeting Macrophages as Potential Clinical Therapeutic Agents Against Cancer and Inflammation.
Guorong Hu,Mengfei Guo,Juanjuan Xu,Feng Wu,Jinshuo Fan,Qi Huang,Guanghai Yang,Zhilei Lv,Xuan Wang,Yang Jin +9 more
TL;DR: In this article, the authors present a brief background information of nanoparticles as drug carriers, including but not limited to the types of nanomaterials, their biological properties and their advantages in clinical application.
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The effect of hydrophilic titanium surface modification on macrophage inflammatory cytokine gene expression.
TL;DR: Down-regulation of the expression of pro-inflammatory cytokine genes may modulate the inflammatory response and may facilitate the enhanced bone wound healing and osseointegration observed clinically using implants with a microrough hydrophilic surface.
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Monocytes/macrophages and sepsis.
TL;DR: Monocytes are mononuclear phagocytes within the bloodstream and are the main effectors of innate immunity because of their capacity to ingest microbes, their antimicrobial activity, and their role as a main source of inflammatory mediators.
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Molecular mechanisms of crystal-related kidney inflammation and injury. Implications for cholesterol embolism, crystalline nephropathies and kidney stone disease
TL;DR: The proven and potential mechanisms of renal inflammation and kidney injury in crystal-related kidney disorders are discussed and topics for further research in that field are listed.
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The Roles of Hypoxia Signaling in the Pathogenesis of Cardiovascular Diseases.
TL;DR: The purpose of this review is to give a brief overview of the current understanding about the function HIF-α in inflammation processes especially by focusing on its roles in macrophages and the pathophysiological roles of hypoxia signaling for the development of cardiovascular disease.
References
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International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels
William A. Catterall,K. G. Chandy,David E. Clapham,George A. Gutman,Franz Hofmann,Anthony J. Harmar,Darrell R. Abernethy,Michael Spedding +7 more
TL;DR: This issue of Pharmacological Reviews includes a new venture in the collaboration between the International Union of Pharmacology (IUPHAR) and the American Society for Pharmacology and Experimental Therapeutics (ASPET), in that a new classification of voltage-gated ion channels is outlined.
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Alternative activation of macrophages
TL;DR: The evidence in favour of alternative macrophage activation by the TH2-type cytokines interleukin-4 (IL-4) and IL-13 is assessed, and its limits and relevance to a range of immune and inflammatory conditions are defined.
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Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
Alberto Mantovani,Silvano Sozzani,Silvano Sozzani,Massimo Locati,Paola Allavena,Antonio Sica +5 more
TL;DR: These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression.
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NF-kappaB regulation in the immune system.
Qiutang Li,Inder M. Verma +1 more
TL;DR: The role of NF-κB proteins as potential therapeutic targets in clinical applications and their role in the immune system and inflammatory diseases are discussed.
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Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties
TL;DR: Using a murine adoptive transfer system to probe monocyte homing and differentiation in vivo, two functional subsets among murine blood monocytes are identified: a short-lived CX(3)CR1(lo)CCR2(+)Gr1(+) subset that is actively recruited to inflamed tissues and a CX (3) CR1(hi)CCS1-dependent recruitment to noninflamed tissues.