Journal ArticleDOI
The chemokine system in diverse forms of macrophage activation and polarization.
Alberto Mantovani,Alberto Mantovani,Antonio Sica,Silvano Sozzani,Silvano Sozzani,Paola Allavena,Annunciata Vecchi,Massimo Locati +7 more
Reads0
Chats0
TLDR
Recent evidence suggests that differential modulation of the chemokine system integrates polarized macrophages in pathways of resistance to, or promotion of, microbial pathogens and tumors, or immunoregulation, tissue repair and remodeling.About:
This article is published in Trends in Immunology.The article was published on 2004-12-01. It has received 5568 citations till now. The article focuses on the topics: Macrophage polarization & M2 Macrophage.read more
Citations
More filters
Journal ArticleDOI
The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection
Takashi Satoh,Osamu Takeuchi,Alexis Vandenbon,Koubun Yasuda,Yoshiaki Tanaka,Yutaro Kumagai,Tohru Miyake,Kazufumi Matsushita,Toshihiko Okazaki,Tatsuya Saitoh,Kiri Honma,Toshifumi Matsuyama,Katsuyuki Yui,Tohru Tsujimura,Daron M. Standley,Kenji Nakanishi,Kenta Nakai,Shizuo Akira +17 more
TL;DR: Results show that Jmjd3-mediated H3K27 demethylation is crucial for regulating M2 macrophage development leading to anti-helminth host responses.
Journal ArticleDOI
Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine
TL;DR: Allogeneic MSC treatments, categorized as a drug by regulatory agencies, have been widely pursued, but new studies demonstrate the efficacy of autologous MSC therapies, even for individuals affected by a disease state.
Journal ArticleDOI
Increased Inflammatory Properties of Adipose Tissue Macrophages Recruited During Diet-Induced Obesity
TL;DR: It is demonstrated that recruited ATMs in obese animals represent a subclass of macrophages with unique properties, and ATMs from obese mice had increased lipid content compared with those from lean mice.
Journal ArticleDOI
Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS-) vs. Alternatively Activated Macrophages.
TL;DR: This fundamental discrepancy explains why most surface markers identified on in vitro generated macrophages do not translate to the in vivo situation and is justified by comparing the gene lists positively or negatively correlated with the ratio of IL-12 and arginase 1 in transcriptomes of LPS-treated peritoneal macrophades.
Journal ArticleDOI
Regulatory interactions between muscle and the immune system during muscle regeneration
TL;DR: Evidence that indicates that the response of myeloid cells to muscle injury promotes muscle regeneration and growth is evaluated, showing that transitions in macrophage phenotype are an essential component of muscle regeneration in vivo following acute or chronic muscle damage.
References
More filters
Journal ArticleDOI
International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels
William A. Catterall,K. G. Chandy,David E. Clapham,George A. Gutman,Franz Hofmann,Anthony J. Harmar,Darrell R. Abernethy,Michael Spedding +7 more
TL;DR: This issue of Pharmacological Reviews includes a new venture in the collaboration between the International Union of Pharmacology (IUPHAR) and the American Society for Pharmacology and Experimental Therapeutics (ASPET), in that a new classification of voltage-gated ion channels is outlined.
Journal ArticleDOI
Alternative activation of macrophages
TL;DR: The evidence in favour of alternative macrophage activation by the TH2-type cytokines interleukin-4 (IL-4) and IL-13 is assessed, and its limits and relevance to a range of immune and inflammatory conditions are defined.
Journal ArticleDOI
Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
Alberto Mantovani,Silvano Sozzani,Silvano Sozzani,Massimo Locati,Paola Allavena,Antonio Sica +5 more
TL;DR: These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression.
Journal ArticleDOI
NF-kappaB regulation in the immune system.
Qiutang Li,Inder M. Verma +1 more
TL;DR: The role of NF-κB proteins as potential therapeutic targets in clinical applications and their role in the immune system and inflammatory diseases are discussed.
Journal ArticleDOI
Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties
TL;DR: Using a murine adoptive transfer system to probe monocyte homing and differentiation in vivo, two functional subsets among murine blood monocytes are identified: a short-lived CX(3)CR1(lo)CCR2(+)Gr1(+) subset that is actively recruited to inflamed tissues and a CX (3) CR1(hi)CCS1-dependent recruitment to noninflamed tissues.