Journal ArticleDOI
The chemokine system in diverse forms of macrophage activation and polarization.
Alberto Mantovani,Alberto Mantovani,Antonio Sica,Silvano Sozzani,Silvano Sozzani,Paola Allavena,Annunciata Vecchi,Massimo Locati +7 more
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TLDR
Recent evidence suggests that differential modulation of the chemokine system integrates polarized macrophages in pathways of resistance to, or promotion of, microbial pathogens and tumors, or immunoregulation, tissue repair and remodeling.About:
This article is published in Trends in Immunology.The article was published on 2004-12-01. It has received 5568 citations till now. The article focuses on the topics: Macrophage polarization & M2 Macrophage.read more
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Curcumin induces M2 macrophage polarization by secretion IL-4 and/or IL-13.
Shanshan Gao,Juan Zhou,Na Liu,Lijun Wang,Qiyue Gao,Yan Wu,Qiang Zhao,Peining Liu,Shun Wang,Yan Liu,Ning Guo,Yan Shen,Yue Wu,Zuyi Yuan +13 more
TL;DR: Results show that curcumin induces macrophage M2 polarization by secretion of IL-4 and/or IL-13 and ameliorates EAM by reducing infiltration inflammatory macrophages and by polarizing M0 and M1 macrophaging to M2 phenotype.
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CCR2 deficiency impairs macrophage infiltration and improves cognitive function after traumatic brain injury.
Christine L. Hsieh,Eréne C. Niemi,Sarah H. Wang,Chih Cheng Lee,Deborah Bingham,Jiasheng Zhang,Myrna L. Cozen,Israel F. Charo,Eric J. Huang,Jialing Liu,Mary C. Nakamura +10 more
TL;DR: Results suggest that therapeutic blockade of CCR2-dependent responses may improve outcomes following TBI, and demonstrate that Ccr2 directs the majority of macrophage homing to the brain early after TBI and indicates that CCr2 may facilitate harmful responses.
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Targeting tumor-infiltrating macrophages to combat cancer
TL;DR: Macrophage phenotypic heterogeneity, the current understanding of how tumors take advantage of macrophage plasticity to generate immunosuppression, and how manipulation of specific macrophages populations can be used for therapeutic purposes through translational approaches are summarized.
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Metabolic regulation of macrophage phenotype and function
TL;DR: Evidence pertaining to the crucial role of metabolism and metabolites in shaping the phenotype and function of macrophages is reviewed here.
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Applications of Metals for Bone Regeneration
Kristina Glenske,Phil Donkiewicz,Alexander Köwitsch,Nada Milosevic-Oljaca,Patrick Rider,Sven Rofall,Jörg Franke,Ole Jung,Ralf Smeets,Reinhard Schnettler,Sabine Wenisch,Mike Barbeck +11 more
TL;DR: The present review focuses on frequently used metals as integral parts of materials designed for bone regeneration, with the aim to provide an overview of currently existing knowledge about the effects of metals in the field of bone regeneration.
References
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International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels
William A. Catterall,K. G. Chandy,David E. Clapham,George A. Gutman,Franz Hofmann,Anthony J. Harmar,Darrell R. Abernethy,Michael Spedding +7 more
TL;DR: This issue of Pharmacological Reviews includes a new venture in the collaboration between the International Union of Pharmacology (IUPHAR) and the American Society for Pharmacology and Experimental Therapeutics (ASPET), in that a new classification of voltage-gated ion channels is outlined.
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Alternative activation of macrophages
TL;DR: The evidence in favour of alternative macrophage activation by the TH2-type cytokines interleukin-4 (IL-4) and IL-13 is assessed, and its limits and relevance to a range of immune and inflammatory conditions are defined.
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Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
Alberto Mantovani,Silvano Sozzani,Silvano Sozzani,Massimo Locati,Paola Allavena,Antonio Sica +5 more
TL;DR: These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression.
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NF-kappaB regulation in the immune system.
Qiutang Li,Inder M. Verma +1 more
TL;DR: The role of NF-κB proteins as potential therapeutic targets in clinical applications and their role in the immune system and inflammatory diseases are discussed.
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Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties
TL;DR: Using a murine adoptive transfer system to probe monocyte homing and differentiation in vivo, two functional subsets among murine blood monocytes are identified: a short-lived CX(3)CR1(lo)CCR2(+)Gr1(+) subset that is actively recruited to inflamed tissues and a CX (3) CR1(hi)CCS1-dependent recruitment to noninflamed tissues.