Journal ArticleDOI
The Current State of Epicutaneous Immunotherapy for Food Allergy: a Comprehensive Review.
TLDR
Clinical data is lacking, but relatively small and early studies suggest that EPIT has an excellent safety profile, particularly compared to other methods of specific allergen immunotherapy, which is needed to prove efficacy and further demonstrate the safety profile of EPIT for food allergy.Abstract:
The food allergy epidemic of recent years has led to the search for safe and effective methods of immunotherapy for foods. Studies of epicutaneous immunotherapy (EPIT) in mice have shown promising safety and efficacy data. Murine models have also identified probable mechanisms for the development of tolerance to food allergens, including the induction of regulatory T cells. Clinical data is lacking, but relatively small and early studies among peanut and cow’s milk allergic subjects suggest that EPIT has an excellent safety profile, particularly compared to other methods of specific allergen immunotherapy. Efficacy data are also promising for peanut allergy, among younger patients (ages 4–11 years of age), suggesting that a majority of young patients will experience an increase in reaction threshold with therapy. The goal of this therapy is the protection from accidental exposures to a known food allergen. Additional clinical data is needed to prove efficacy and further demonstrate the safety profile of EPIT for food allergy, prior to approval by the Food and Drug Administration.read more
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Journal ArticleDOI
Recent developments and highlights in food allergy.
TL;DR: In a recent study, this article showed that routine food allergy testing is poor at predicting clinical allergy for tree nuts, almonds in particular, and that more advanced antigen-based tests including component-resolved diagnostics and epitope reactivity may lead to more accurate diagnosis and selection of therapeutic intervention.
Journal ArticleDOI
Molecular Approaches for Diagnosis, Therapy and Prevention of Cow’s Milk Allergy
Birgit Linhart,Raphaela Freidl,Olga Elisyutina,Musa Khaitov,Alexander Karaulov,Rudolf Valenta,Rudolf Valenta +6 more
TL;DR: Current strategies for prevention and treatment of cow’s milk allergy are reviewed and how they could be improved in the future by innovative molecular approaches that are based on defined recombinant allergens, recombinant hypo allergen derivatives and synthetic peptides.
Journal Article
Intestinal Tolerance Requires Gut Homing and Expansion of FoxP3 + Regulatory T Cells in the Lamina P
Usriansyah Hadis,Benjamin Wahl,Olga Schulz,Matthias Hardtke-Wolenski,Angela Schippers,Norbert Wagner,Werner Müller,Tim Sparwasser,Reinhold Förster,Oliver Pabst +9 more
TL;DR: In this article, the authors use several mouse models to show that Treg cells, after their generation in lymph nodes, need to home to the gut to undergo local expansion to install oral tolerance.
Journal ArticleDOI
Newly identified T cell subsets in mechanistic studies of food immunotherapy
Vanitha Sampath,Kari C. Nadeau +1 more
TL;DR: The initial simplistic view that restoring Th1/Th2 balance by decreasing Th2 or increasing Th1 responses can ameliorate food allergy is being enhanced by a more complex model involving other T cell subsets, particularly Tregs.
Journal ArticleDOI
Epicutaneous sensitization to food allergens in atopic dermatitis: What do we know?
Elizabeth Huiwen Tham,Elizabeth Huiwen Tham,Mohana Rajakulendran,Bee Wah Lee,Hugo Van Bever,Hugo Van Bever +5 more
TL;DR: The mechanisms underpinning the development of epicutaneous sensitization to food allergens and progression to clinical food allergy are described and current evidence for interventions to halt the progression is summarized to highlight unmet needs and directions for future research.
References
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Journal ArticleDOI
The Prevalence, Severity, and Distribution of Childhood Food Allergy in the United States
Ruchi Gupta,Elizabeth E. Springston,Manoj R. Warrier,Bridget Smith,Bridget Smith,Rajesh Kumar,Jacqueline A. Pongracic,Jacqueline A. Pongracic,Jane L. Holl +8 more
TL;DR: Findings suggest that the prevalence and severity of childhood food allergy is greater than previously reported and that disparities exist in the clinical diagnosis of disease.
Journal ArticleDOI
US prevalence of self-reported peanut, tree nut, and sesame allergy: 11-year follow-up
TL;DR: Although caution is required in comparing surveys, peanut allergy, TN allergy, or both continue to be reported by more than 1% of the US population and appear to be increasingly reported among children over the past decade.
Journal ArticleDOI
Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria
Usriansyah Hadis,Benjamin Wahl,Olga Schulz,Matthias Hardtke-Wolenski,Angela Schippers,Norbert Wagner,Werner Müller,Tim Sparwasser,Reinhold Förster,Oliver Pabst +9 more
TL;DR: A model of stepwise oral tolerance induction induction comprising the generation of Treg cells in the gut-draining lymph nodes, followed by migration into the gut and subsequent expansion of T Reg cells driven by intestinal macrophages is proposed.
Journal ArticleDOI
Food allergy: a practice parameter update-2014.
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TL;DR: This parameter was developed by the Joint Task Force on Practice Parameters, representing the American Academy of Allergy, Asthma & Immunology (AAAAI), the American College of Allerg, Acetiology & Infectious Diseases (ACAAI); and the Joint Council of Allergic, Aceto-Allergy, Immunology and Immunology(JCAAI) as discussed by the authors.
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Treatment of anaphylactic sensitivity to peanuts by immunotherapy with injections of aqueous peanut extract
TL;DR: Injections of peanut extract increase the tolerance of patients with peanut allergy to oral ingestion of peanuts, even during maintenance injections, which result in repeated systemic reactions in most patients.
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