Journal ArticleDOI
The development of hippocampal interneurons in rodents
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TLDR
The migration toward and within the hippocampus, and the maturation of their morphological and neurochemical characteristics are detailed, and potential mechanisms underlying the development of GABAergic interneurons are reviewed.Abstract:
Interneurons are GABAergic neurons responsible for inhibitory activity in the adult hippocampus, thereby controlling the activity of principal excitatory cells through the activation of postsynaptic GABAA receptors. Subgroups of GABAergic neurons innervate specific parts of excitatory neurons. This specificity indicates that particular interneuron subgroups are able to recognize molecules segregated on the membrane of the pyramidal neuron. Once these specific connections are established, a quantitative regulation of their strength must be performed to achieve the proper balance of excitation and inhibition. We will review when and where interneurons are generated. We will then detail their migration toward and within the hippocampus, and the maturation of their morphological and neurochemical characteristics. We will finally review potential mechanisms underlying the development of GABAergic interneurons.read more
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Hippocampal sharp wave‐ripple: A cognitive biomarker for episodic memory and planning
TL;DR: Alteration of the physiological mechanisms supporting SPW‐Rs leads to their pathological conversion, “p‐ripples,” which are a marker of epileptogenic tissue and can be observed in rodent models of schizophrenia and Alzheimer's Disease.
Journal ArticleDOI
Fate mapping Nkx2.1-lineage cells in the mouse telencephalon.
TL;DR: F fate‐mapping data on Nkx2.1‐lineage neurons throughout the telencephalon is presented, including the cerebral cortex, amygdala, olfactory bulb, striatum, globus pallidus, septum, and nucleus basalis.
Journal ArticleDOI
Recurrent inhibitory circuitry as a mechanism for grid formation
Jonathan J. Couey,Aree Witoelar,Sheng-Jia Zhang,Kang Zheng,Jing Ye,Benjamin Dunn,Rafal Czajkowski,May-Britt Moser,Edvard I. Moser,Yasser Roudi,Menno P. Witter +10 more
TL;DR: It is demonstrated that stellate cells, the principal cell type in the layer II grid network, are mainly interconnected via inhibitory interneurons, and that stable grid firing can emerge from a simple recurrent inhibitory network.
Sequential phases of cortical specificationinvolve Neurogenin-dependentand -independent pathways
Carol Schuurmans,Olivier Armant,Marta Nieto,Jan M Stenman,Olivier Britz,Natalia Klenin,Craig E. Brown,Lisa-Marie Langevin,Julie Seibt,Hua Tang,James M. Cunningham,Richard H. Dyck,Christopher A. Walsh,Kenny Campbell,Franck Polleux,François Guillemot +15 more
TL;DR: It is demonstrated that distinct genetic programs operate at different stages of corticogenesis to specify the properties shared by all neocortical neurons.
Journal ArticleDOI
Pathogenic SYNGAP1 mutations impair cognitive development by disrupting maturation of dendritic spine synapses.
James P. Clement,Massimiliano Aceti,Thomas K. Creson,Emin D. Ozkan,Yulin Shi,Nicholas J. Reish,Antoine G. Almonte,Brooke H. Miller,Brian J. Wiltgen,Courtney A. Miller,Xiangmin Xu,Gavin Rumbaugh +11 more
TL;DR: It is proposed that the pace of dendritic spine synapse maturation in early life is a critical determinant of normal intellectual development.
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TL;DR: Golgi and electronmicroscopic methods were used to define the shapes and intercellular relationships of cells migrating from their sites of origin near the ventricular surface across the intermediate zone to the superficial neocortical layers of the parietooccipital region in the brains of 75‐ to 97‐day monkey fetuses.
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Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases
TL;DR: It is shown here that neurons are generated in two proliferative zones by distinct patterns of division, and newborn neurons do not migrate directly to the cortex; instead, most exhibit four distinct phases of migration, including a phase of retrograde movement toward the ventricle before migration to the cortical plate.