Journal ArticleDOI
The development of the intrahepatic bile ducts in man: a keratin-immunohistochemical study.
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TLDR
The development of the intrahepatic bile ducts in man was studied using an immunohistochemical technique on 56 liver specimens ranging in age from 6 weeks of gestation to 8 months after birth.About:
This article is published in Hepatology.The article was published on 1988-11-01. It has received 285 citations till now. The article focuses on the topics: Intrahepatic bile ducts & Bile duct.read more
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Liver regeneration and repair: Hepatocytes, progenitor cells, and stem cells
TL;DR: The review of the rapidly expanding literature presented here, particularly as it deals with stem cells, was guided by a few principles: be wary of dogma1 and of overinterpretation of data.
Journal ArticleDOI
Congenital diseases of intrahepatic bile ducts: variations on the theme "ductal plate malformation".
TL;DR: This review will emphasize that in most if not all of these conditions, persistence or lack of remodeling of the embryonic ductal plate (so-called “ductal plate malformation” [DPM]) is an essential precursor of the lesions.
Journal ArticleDOI
A liver-on-a-chip platform with bioprinted hepatic spheroids.
Nupura S. Bhise,Vijayan Manoharan,Vijayan Manoharan,Solange Massa,Solange Massa,Solange Massa,Ali Tamayol,Ali Tamayol,Masoumeh Ghaderi,Masoumeh Ghaderi,Mario Miscuglio,Mario Miscuglio,Qi Lang,Qi Lang,Yu Shrike Zhang,Yu Shrike Zhang,Su Ryon Shin,Su Ryon Shin,Giovanni Calzone,Giovanni Calzone,Nasim Annabi,Nasim Annabi,Thomas Shupe,Colin E. Bishop,Anthony Atala,Mehmet R. Dokmeci,Mehmet R. Dokmeci,Ali Khademhosseini,Ali Khademhosseini,Ali Khademhosseini +29 more
TL;DR: Treatment with 15 mM acetaminophen induced a toxic response in the hepatic construct that was similar to published studies on animal and other in vitro models, thus providing a proof-of-concept demonstration of the utility of this liver-on-a-chip platform for toxicity assessment.
Journal ArticleDOI
Isolation and characterization of a stem cell population from adult human liver
Maria Beatriz Herrera,Stefania Bruno,Stefano Buttiglieri,Ciro Tetta,Stefano Gatti,Maria Chiara Deregibus,Benedetta Bussolati,Giovanni Camussi +7 more
TL;DR: A pluripotent progenitor population in adult human liver that could provide a basis for cell therapy strategies is identified and characterized by stringent conditions of liver cell cultures.
Journal ArticleDOI
The onecut transcription factor HNF6 is required for normal development of the biliary tract
Frédéric Clotman,Vincent Lannoy,Michael Reber,Silvia Cereghini,David Cassiman,Patrick Jacquemin,Tania Roskams,Guy G. Rousseau,Frédéric P. Lemaigre +8 more
TL;DR: It is concluded that H NF6 is essential for differentiation and morphogenesis of the biliary tract and that intrahepatic bile duct development is controlled by a HNF6-->HNF1beta cascade.
References
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The catalog of human cytokeratins: Patterns of expression in normal epithelia, tumors and cultured cells
TL;DR: During cell transformation and tumor devel- opment this cell type specificity of intermediate filaments is largely conserved’ and classification of tumors by their specific type of intermediate Filaments has re- cently become very valuable in clinical histodiagnosis.
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Monoclonal antibody to cytokeratin for use in routine histopathology.
TL;DR: CAM 5.2 is a murine monoclonal antibody, raised against the colon carcinoma cell line HT29, which recognises lower molecular weight intracellular cytokeratin proteins within secretory epithelia.
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Monoclonal antibodies provide specific intramolecular markers for the study of epithelial tonofilament organization.
TL;DR: The monoclonal antibodies described here demonstrate the presence of a simple epithelium antigenic determinant associated with intermediate filaments that is not detectable in the specialized cells of squamous and keratinizing epithelia but can reappear in such cells after transformation.
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Antibody to prekeratin: Decoration of tonofilament-like arrays in various cells of epithelial character
TL;DR: It is concluded that several epithelial cells which are capable of continuous division in culture continuously produce large, balanced amounts of prekeratin-like material which is assembled in tonofilament-like structures.
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Complex Cytokeratin Polypeptide Patterns Observed in Certain Human Carcinomas
TL;DR: Using cytoskeletal proteins from human biopsies and autopsies, the cytokeratin polypeptide patterns of diverse primary and metastatic carcinomas are examined and compared with those of corresponding normal epithelial tissues and cultured cells and the possibility of cell type heterogeneity within a given tumor is discussed.