Journal ArticleDOI
The Efficacy of Acamprosate and Naltrexone in the Treatment of Alcohol Dependence: A Relative Benefits Analysis of Randomized Controlled Trials
James L. Snyder,Thomas G. Bowers +1 more
TLDR
Short-term administration of naltrexone significantly reduced the relapse rate, but was not associated with modification in the abstinence rate, and acamprosate use demonstrated a modest improvement, with a RB of 1.76 at three month follow-up.Abstract:
Random controlled trials on the efficacy of naltrexone and acamprosate in the treatment of alcohol dependence were reviewed, using a Relative Benefit (RB) analysis approach. A total of 42 studies were included, showing acamprosate use demonstrated a modest improvement, with a RB of 1.76 at three month follow-up. Short-term administration of naltrexone significantly reduced the relapse rate, but was not associated with modification in the abstinence rate. There was insufficient data available to ascertain the efficacy of naltrexone and acamprosate over prolonged periods of time, or the effectiveness of the medications relative to each other.read more
Citations
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Pharmacotherapy for Adults With Alcohol-Use Disorders in Outpatient Settings
Daniel E Jonas,Halle R Amick,Cynthia Feltner,Georgiy Bobashev,Kathleen C. Thomas,Roberta Wines,Mimi M. Kim,Ellen Shanahan,C Elizabeth Gass,Cassandra J Rowe,James C. Garbutt +10 more
TL;DR: A systematic review and meta-analysis of the benefits and harms of medications for adults with alcohol use disorders found moderate evidence supports an association with improvement in some consumption outcomes for nalmefene and topiramate.
Journal ArticleDOI
Meta‐analysis of naltrexone and acamprosate for treating alcohol use disorders: when are these medications most helpful?
Natalya C. Maisel,Janet C. Blodgett,Paula L. Wilbourne,Keith Humphreys,Keith Humphreys,John W. Finney,John W. Finney +6 more
TL;DR: A meta-analysis examined when naltrexone and acamprosate are most helpful by testing the relative efficacy of each medication given its presumed mechanism of action and whether different ways of implementing each medication moderate its effects.
Journal ArticleDOI
Glutamatergic medications for the treatment of drug and behavioral addictions
TL;DR: It is concluded that manipulation of glutamatergic neurotransmission is a relatively young but promising avenue for the development of improved therapeutic agents for the treatment of drug and behavioral addictions.
Journal ArticleDOI
Activation instead of blocking mesolimbic dopaminergic reward circuitry is a preferred modality in the long term treatment of reward deficiency syndrome (RDS): a commentary.
Kenneth Blum,Amanda Lih Chuan Chen,Thomas J H Chen,Eric R Braverman,Jeffrey Reinking,Seth H. Blum,Kimberly Cassel,Bernard W. Downs,Roger L. Waite,Lonna Williams,Thomas J. Prihoda,Mallory Kerner,Tomás Palomo,David E. Comings,Howard Tung,Patrick Rhoades,Marlene Oscar-Berman +16 more
TL;DR: D2 receptor stimulation can be accomplished via the use of Synapatmine™, a natural but therapeutic nutraceutical formulation that potentially induces DA release, causing the same induction of D 2-directed mRNA and thus proliferation of D2 receptors in the human, which will induce the attenuation of craving behavior.
Journal ArticleDOI
Barriers to Use of Pharmacotherapy for Addiction Disorders and How to Overcome Them
TL;DR: The barriers that may contribute to poor adoption and utilization of pharmacotherapy for alcohol and opioid dependence at the system, provider, and patient level are described and ways to overcome those barriers are discussed.
References
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Journal ArticleDOI
Meta-Analysis in Clinical Trials*
TL;DR: This paper examines eight published reviews each reporting results from several related trials in order to evaluate the efficacy of a certain treatment for a specified medical condition and suggests a simple noniterative procedure for characterizing the distribution of treatment effects in a series of studies.
Book
Statistical Methods for Meta-Analysis
Larry V. Hedges,Ingram Olkin +1 more
TL;DR: In this article, the authors present a model for estimating the effect size from a series of experiments using a fixed effect model and a general linear model, and combine these two models to estimate the effect magnitude.
Reference EntryDOI
Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR)
TL;DR: The Diagnostic and Statistical Manual of Mental Disorders, fourth edition, text revision (DSM-IV-TR) (American Psychiatric Association], 2000) is a compendium of mental disorders, a listing of the criteria used to diagnose them, and a detailed system for their definition, organization, and classification.
Book ChapterDOI
Statistical Methods for Meta‐Analysis
Journal ArticleDOI
Naltrexone and Coping Skills Therapy for Alcohol Dependence: A Controlled Study
Stephanie S. O'Malley,Adam J. Jaffe,Adam J. Jaffe,Grace Chang,Richard S. Schottenfeld,Roger E. Meyer,Bruce J. Rounsaville,Bruce J. Rounsaville +7 more
TL;DR: Naltrexone proved superior to placebo in measures of drinking and alcohol- related problems, including abstention rates, number of drinking days, relapse, and severity of alcohol-related problems.
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Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence: The COMBINE Study: A Randomized Controlled Trial
Raymond F. Anton,Stephanie S. O'Malley,Domenic A. Ciraulo,Ron A. Cisler,David Couper,Dennis M. Donovan,David R. Gastfriend,James D. Hosking,Bankole A. Johnson,Joseph S. LoCastro,Richard Longabaugh,Barbara J. Mason,Margaret E. Mattson,William R. Miller,Helen M. Pettinati,Carrie L. Randall,Robert M. Swift,Roger D. Weiss,Lauren D. Williams,Allen Zweben +19 more