Journal ArticleDOI
The embryonic development of mammalian neural tube defects.
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This article is published in Progress in Neurobiology.The article was published on 1990-01-01. It has received 326 citations till now. The article focuses on the topics: Neural plate & Neural tube.read more
Citations
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A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects?
Nathalie M.J. van der Put,Fons J. M. Gabreëls,Erik M. B. Stevens,Jan A.M. Smeitink,Frans J.M. Trijbels,Tom K.A.B. Eskes,Lambert P. van den Heuvel,Henk J. Blom +7 more
TL;DR: The data suggest that the combined heterozygosity for the two MTHFR common mutations accounts for a proportion of folate-related NTDs, which is not explained by homozygosity by the 677(C-->T) mutation, and can be an additional genetic risk factor for N TDs.
Journal ArticleDOI
The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development.
Chia-Yi Kuan,Derek D. Yang,Deborah R. Samanta Roy,Roger J. Davis,Pasko Rakic,Richard A. Flavell +5 more
TL;DR: It is suggested that Jnk1 andJnk2 regulate region-specific apoptosis during early brain development by reducing cell death in the lateral edges of hindbrain prior to neural tube closure and increasing apoptosis and caspase activation in the mutant forebrain.
Journal ArticleDOI
Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects.
Makoto Ishibashi,Siew-Lan Ang,Kohei Shiota,S Nakanishi,Ryoichiro Kageyama,François Guillemot +5 more
TL;DR: Results suggest that HES-1 normally controls the proper timing of neurogenesis and regulates neural tube morphogenesis.
Journal ArticleDOI
Disruption of the Hox-1.6 homeobox gene results in defects in a region corresponding to its rostral domain of expression
Thomas Lufkin,Andrée Dierich,Andrée Dierich,Marianne LeMeur,Marianne LeMeur,Manuel Mark,Manuel Mark,Pierre Chambon,Pierre Chambon +8 more
TL;DR: Within the same region of the presumptive hindbrain, two HOX-1 genes are involved in the patterning of two different populations of neural crest cells, and the implication of these results for the function of the Hox network during mouse embryogenesis is discussed.
Journal ArticleDOI
The genetic basis of mammalian neurulation
TL;DR: More than 80 mutant mouse genes disrupt neurulation and allow an in-depth analysis of the underlying developmental mechanisms, including the planar cell-polarity pathway and the sonic hedgehog signalling pathway that regulates neural plate bending.
References
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Journal Article
A formaldehyde-glutaraldehyde fixative of high osmolality for use in electron-microscopy
Journal ArticleDOI
Retinoic Acid Embryopathy
TL;DR: It is possible that a major mechanism of isotretinoin teratogenesis is a deleterious effect on cephalic neural-crest cell activity that results in the observed craniofacial, cardiac, and thymic malformations.
Journal ArticleDOI
The cadherins: cell-cell adhesion molecules controlling animal morphogenesis.
TL;DR: It appears that each cadherin subclass has binding specificity and this molecular family is involved in selective cell-cell adhesion, indicating a crucial role in construction of tissues and the whole animal body.
Book
The developing human
Keith L. Moore,T. V. N. Persaud +1 more
TL;DR: The developing human :, The developing human as discussed by the authors, کتابخانه دیجیتالی دانشگاه علوم پزش
Journal ArticleDOI
Role of transforming growth factor-beta in the development of the mouse embryo.
U. Heine,E. F. Munoz,Kathleen C. Flanders,L R Ellingsworth,H.-Y. P. Lam,Nancy L. Thompson,Anita B. Roberts,Michael B. Sporn +7 more
TL;DR: Using immunohistochemical methods, the role of transforming growth factor-beta (TGF-beta) in the development of the mouse embryo is investigated and its ability to control both synthesis and degradation of both structural and adhesion molecules of the extracellular matrix is discussed.
Related Papers (5)
Mechanisms of neurulation: traditional viewpoint and recent advances
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Prevention of the First Occurrence of Neural-Tube Defects by Periconceptional Vitamin Supplementation
Andrew E. Czeizel,István Dudás +1 more