Journal ArticleDOI
The emergence of optical elastography in biomedicine
TLDR
Optical elastography, the use of optics to characterize and map the mechanical properties of biological tissue, involves measuring the deformation of tissue in response to a load.Abstract:
Optical elastography, the use of optics to characterize and map the mechanical properties of biological tissue, involves measuring the deformation of tissue in response to a load. Such measurements may be used to form an image of a mechanical property, often elastic modulus, with the resulting mechanical contrast complementary to the more familiar optical contrast. Optical elastography is experiencing new impetus in response to developments in the closely related fields of cell mechanics and medical imaging, aided by advances in photonics technology, and through probing the microscale between that of cells and whole tissues. Two techniques — optical coherence elastography and Brillouin microscopy — have recently shown particular promise for medical applications, such as in ophthalmology and oncology, and as new techniques in cell mechanics.read more
Citations
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Journal ArticleDOI
Brillouin microscopy: an emerging tool for mechanobiology
Robert Prevedel,Alba Diz-Muñoz,Giancarlo Ruocco,Giancarlo Ruocco,Giuseppe Antonacci,Giuseppe Antonacci +5 more
TL;DR: This Review discusses the principles, advantages and limitations of Brillouin microscopy, a non-invasive tool for measuring mechanical properties of biological samples in three dimensions, as well as its potential for gaining insights in biology.
Journal ArticleDOI
Vector method for strain estimation in phase-sensitive optical coherence elastography
Alexander L. Matveyev,Lev A. Matveev,A. A. Sovetsky,Grigory V. Gelikonov,A. A. Moiseev,Vladimir Y. Zaitsev +5 more
TL;DR: Modifications of the vector method are paid to make it especially suitable for processing deformations with significant lateral inhomogeneity, which often occur in real situations.
Journal ArticleDOI
3D models in the new era of immune oncology: focus on T cells, CAF and ECM.
Francesca Di Modugno,Cristina Colosi,Paola Trono,Giuseppe Antonacci,Giancarlo Ruocco,Paola Nisticò +5 more
TL;DR: Current knowledge on tumor microenvironment, focusing on T cells, cancer associated fibroblasts and extracellular matrix is reviewed, and the use of 3D cell culture models to resemble tumor micro environment landscape and to screen immunomodulatory drugs is reviewed.
Quantification of plaque stiffness byBrillouin microscopy in experimentalthin cap fibroatheroma
Giuseppe Antonacci,Ryan M. Pedrigi,Avinash Kondiboyina,Vikram V. Mehta,Ranil de Silva,Carl Paterson,Rob Krams,Peter Török +7 more
TL;DR: This is the first study, to the best of the knowledge, to apply Brillouin spectroscopy to quantify atherosclerotic plaque stiffness, which motivates combining this technology with intravascular imaging to improve detection of vulnerable plaques in patients.
Journal ArticleDOI
Strain and elasticity imaging in compression optical coherence elastography: The two‐decade perspective and recent advances
Vladimir Y. Zaitsev,Alexander L. Matveyev,Lev A. Matveev,Alexander A. Sovetsky,Matt S. Hepburn,Matt S. Hepburn,Alireza Mowla,Alireza Mowla,Brendan F. Kennedy,Brendan F. Kennedy +9 more
TL;DR: The underlying principles of C-OCE are focused on, various practical challenges in its realization are discussed and examples of biomedical applications of the technique are presented.
References
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Journal ArticleDOI
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Shang Wang,Kirill V. Larin +1 more
TL;DR: This report reports on the first noncontact depth-resolved micro-scale optical coherence elastography of the cornea achieved using shear wave imaging Optical coherence tomography (SWI-OCT) combined with the spectral analysis of the Corneal Lamb wave propagation.
Journal ArticleDOI
Multicenter Study of Ultrasound Real-Time Tissue Elastography in 779 Cases for the Assessment of Breast Lesions: Improved Diagnostic Performance by Combining the BI-RADS®-US Classification System with Sonoelastography
Sebastian Wojcinski,André Farrokh,Stefan Weber,Anke Thomas,Thomas Fischer,T. Slowinski,Werner Schmidt,Friedrich Degenhardt +7 more
TL;DR: The data demonstrates that the complementary use of sonoelastography definitely improves the performance in breast diagnostics and can be integrated into daily practice.
Journal ArticleDOI
Optical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure
Brendan F. Kennedy,Robert A. McLaughlin,Kelsey M. Kennedy,Lixin Chin,Andrea Curatolo,Alan Tien,Bruce Latham,Christobel Saunders,David D. Sampson +8 more
TL;DR: This work uses phase-sensitive, three-dimensional optical coherence tomography (OCT) to probe the nanometer-to-micrometer-scale axial displacements in tissues induced by compressive loading to reveal micro-scale mechanical contrast in human breast and lymph node tissues.
Journal ArticleDOI
In Vivo Biomechanical Mapping of Normal and Keratoconus Corneas
TL;DR: In this paper, the elastic modulus of normal and keratoconus patients was mapped using Brillouin microscopy and the authors found distinctive biomechanical features that differentiate normal and keratoconic corneas.
Journal ArticleDOI
3D static elastography at the micrometer scale using Full Field OCT.
TL;DR: A proof of concept on multi-layer phantoms and preliminary results on ex vivo biological samples such as porcine cornea, human breast tissues and rat heart are presented.
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