Journal ArticleDOI
The emergence of optical elastography in biomedicine
TLDR
Optical elastography, the use of optics to characterize and map the mechanical properties of biological tissue, involves measuring the deformation of tissue in response to a load.Abstract:
Optical elastography, the use of optics to characterize and map the mechanical properties of biological tissue, involves measuring the deformation of tissue in response to a load. Such measurements may be used to form an image of a mechanical property, often elastic modulus, with the resulting mechanical contrast complementary to the more familiar optical contrast. Optical elastography is experiencing new impetus in response to developments in the closely related fields of cell mechanics and medical imaging, aided by advances in photonics technology, and through probing the microscale between that of cells and whole tissues. Two techniques — optical coherence elastography and Brillouin microscopy — have recently shown particular promise for medical applications, such as in ophthalmology and oncology, and as new techniques in cell mechanics.read more
Citations
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Journal ArticleDOI
Brillouin microscopy: an emerging tool for mechanobiology
Robert Prevedel,Alba Diz-Muñoz,Giancarlo Ruocco,Giancarlo Ruocco,Giuseppe Antonacci,Giuseppe Antonacci +5 more
TL;DR: This Review discusses the principles, advantages and limitations of Brillouin microscopy, a non-invasive tool for measuring mechanical properties of biological samples in three dimensions, as well as its potential for gaining insights in biology.
Journal ArticleDOI
Vector method for strain estimation in phase-sensitive optical coherence elastography
Alexander L. Matveyev,Lev A. Matveev,A. A. Sovetsky,Grigory V. Gelikonov,A. A. Moiseev,Vladimir Y. Zaitsev +5 more
TL;DR: Modifications of the vector method are paid to make it especially suitable for processing deformations with significant lateral inhomogeneity, which often occur in real situations.
Journal ArticleDOI
3D models in the new era of immune oncology: focus on T cells, CAF and ECM.
Francesca Di Modugno,Cristina Colosi,Paola Trono,Giuseppe Antonacci,Giancarlo Ruocco,Paola Nisticò +5 more
TL;DR: Current knowledge on tumor microenvironment, focusing on T cells, cancer associated fibroblasts and extracellular matrix is reviewed, and the use of 3D cell culture models to resemble tumor micro environment landscape and to screen immunomodulatory drugs is reviewed.
Quantification of plaque stiffness byBrillouin microscopy in experimentalthin cap fibroatheroma
Giuseppe Antonacci,Ryan M. Pedrigi,Avinash Kondiboyina,Vikram V. Mehta,Ranil de Silva,Carl Paterson,Rob Krams,Peter Török +7 more
TL;DR: This is the first study, to the best of the knowledge, to apply Brillouin spectroscopy to quantify atherosclerotic plaque stiffness, which motivates combining this technology with intravascular imaging to improve detection of vulnerable plaques in patients.
Journal ArticleDOI
Strain and elasticity imaging in compression optical coherence elastography: The two‐decade perspective and recent advances
Vladimir Y. Zaitsev,Alexander L. Matveyev,Lev A. Matveev,Alexander A. Sovetsky,Matt S. Hepburn,Matt S. Hepburn,Alireza Mowla,Alireza Mowla,Brendan F. Kennedy,Brendan F. Kennedy +9 more
TL;DR: The underlying principles of C-OCE are focused on, various practical challenges in its realization are discussed and examples of biomedical applications of the technique are presented.
References
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Journal ArticleDOI
Elastography of soft materials and tissues by holographic imaging of surface acoustic waves
Karan D. Mohan,Amy L. Oldenburg +1 more
TL;DR: Digital holography is shown to be well-behaved in ex vivo tissue, revealing the subsurface position of a bone and constitutes a flexible new platform for large volume and non-invasive elastography.
Journal ArticleDOI
Serial biomechanical comparison of edematous, normal, and collagen crosslinked human donor corneas using optical coherence elastography
TL;DR: Serial perturbations of the corneal hydration state and CXL had significant effects on corneals biomechanical behavior and show the ability of OCE to quantify clinically relevant mechanical property differences under physiologic conditions.
Journal ArticleDOI
Ultrahigh-resolution optical coherence elastography
Andrea Curatolo,Martin Villiger,Dirk Lorenser,Philip Wijesinghe,Alexander Fritz,Brendan F. Kennedy,David D. Sampson +6 more
TL;DR: The proposed ultrahigh-resolution optical coherence elastography (UHROCE) is proposed, and 3D imaging of local axial strain of tissues undergoing compressive loading is demonstrated, to demonstrate the mechanical heterogeneity of vascular smooth muscle cells and elastin sheets.
Journal ArticleDOI
Quantitative lateral and axial flow imaging with optical coherence microscopy and tomography
TL;DR: A generalized model to analyze the influence of relevant OCT/OCM system parameters such as light source spectrum, numerical aperture and beam geometry on the Doppler spectrum is presented and an optimized acquisition protocol and algorithm are presented to reconstruct quantitative measurements of lateral and axial flow from the Dooppler spectrum.
Journal ArticleDOI
Elastographic mapping in optical coherence tomography using an unconventional approach based on correlation stability
Vladimir Y. Zaitsev,Lev A. Matveev,A. L. Matveyev,Grigory V. Gelikonov,Valentin M. Gelikonov +4 more
TL;DR: An approach to elastographic mapping in optical coherence tomography (OCT) using comparison of correlation stability of sequentially obtained intensity OCT images of the studied strained tissue is discussed, allowing one to avoid the stage of local-strain reconstruction via error-sensitive numerical differentiation of experimentally determined displacements.
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