Journal ArticleDOI
The emergence of optical elastography in biomedicine
TLDR
Optical elastography, the use of optics to characterize and map the mechanical properties of biological tissue, involves measuring the deformation of tissue in response to a load.Abstract:
Optical elastography, the use of optics to characterize and map the mechanical properties of biological tissue, involves measuring the deformation of tissue in response to a load. Such measurements may be used to form an image of a mechanical property, often elastic modulus, with the resulting mechanical contrast complementary to the more familiar optical contrast. Optical elastography is experiencing new impetus in response to developments in the closely related fields of cell mechanics and medical imaging, aided by advances in photonics technology, and through probing the microscale between that of cells and whole tissues. Two techniques — optical coherence elastography and Brillouin microscopy — have recently shown particular promise for medical applications, such as in ophthalmology and oncology, and as new techniques in cell mechanics.read more
Citations
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Journal ArticleDOI
Morpho-mechanics of human collagen superstructures revealed by all-optical correlative micro-spectroscopies
Raffaella Mercatelli,Sara Mattana,Sara Mattana,Laura Capozzoli,Fulvio Ratto,Francesca Rossi,Roberto Pini,Daniele Fioretto,Francesco S. Pavone,Silvia Caponi,Riccardo Cicchi,Riccardo Cicchi +11 more
TL;DR: A correlative study intended to map supramolecular morphology, biochemical composition and viscoelastic parameters of collagen by all-optical microscopies with a method incorporating Brillouin and Raman microscopy with Second-Harmonic-Generation microscopy.
Journal ArticleDOI
Robust reconstruction of local optic axis orientation with fiber-based polarization-sensitive optical coherence tomography.
Qingyun Li,Karol Karnowski,Peter B. Noble,Alvenia Cairncross,Alan James,Martin Villiger,David D. Sampson +6 more
TL;DR: The utility of reconstructing the local optic axis orientation to assess smooth muscle, which is expected to be useful in the assessment of airway smooth muscle thickness in asthma, amongst other fiber-based applications, is demonstrated.
Journal ArticleDOI
Diagnostic Accuracy of Quantitative Micro-Elastography for Margin Assessment in Breast-Conserving Surgery
Kelsey M. Kennedy,Renate R. Zilkens,Renate R. Zilkens,Wes M. Allen,Wes M. Allen,Ken Y. Foo,Ken Y. Foo,Qi Fang,Qi Fang,Lixin Chin,Lixin Chin,Rowan W. Sanderson,Rowan W. Sanderson,James D. Anstie,James D. Anstie,Philip Wijesinghe,Philip Wijesinghe,Andrea Curatolo,Andrea Curatolo,Hsern Ern Tan,Narelle Morin,Bindu Kunjuraman,Chris Yeomans,Synn Lynn Chin,Helen M. DeJong,Katharine Giles,Benjamin F. Dessauvagie,Benjamin F. Dessauvagie,Bruce Latham,Christobel Saunders,Christobel Saunders,Christobel Saunders,Brendan F. Kennedy,Brendan F. Kennedy +33 more
TL;DR: High accuracy of QME for detecting tumor within 1 mm of the margin of BCS specimens is demonstrated and the potential for this technique to improve outcomes in BCS is demonstrated.
Journal ArticleDOI
Non-resonant metasurface for broadband elastic wave mode splitting
TL;DR: In this paper, a non-resonant elastic metasurface design is proposed to achieve a perfect splitting of longitudinal and shear waves in space, where the key to this broadband design is a singly polarized solid with engineered static elastic tensor.
The validity and reliability of using ultrasound elastography to measure cutaneous stiffness, a systematic review.
TL;DR: Robust evidence supporting the use of ultrasoundElastography as a diagnostic tool in cutaneous conditions is low, however, initial indicators support further research to establish the utility of ultrasound elastography in dermatology.
References
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Journal ArticleDOI
Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TL;DR: OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.
Book ChapterDOI
Optical Coherence Tomography
Eric A. Swanson,J. Izatt,M. Bee,David Huang,Charles P. Lin,Carmen A. Puliafito,Carmen A. Puliafito,James G. Fujimoto +7 more
TL;DR: Optical coherence tomography (OCT) has developed rapidly since its first realisation in medicine and is currently an emerging technology in the diagnosis of skin disease as mentioned in this paper, where OCT is an interferometric technique that detects reflected and backscattered light from tissue.
Journal ArticleDOI
Performance of fourier domain vs. time domain optical coherence tomography.
TL;DR: It is shown that FDOCT systems have a large sensitivity advantage and allow for sensitivities well above 80dB, even in situations with low light levels and high speed detection.
Journal ArticleDOI
Shear wave elasticity imaging: a new ultrasonic technology of medical diagnostics
TL;DR: A physical and mathematical basis of SWEI is presented and some experimental results of pilot studies proving feasibility of this new ultrasonic technology are presented, including a theoretical model of shear oscillations in soft biological tissue remotely induced by the radiation force of focused ultrasound.
Journal ArticleDOI
Quantitative assessment on the cloning efficiencies of lentiviral transfer vectors with a unique clone site.
Gang Zhang,Anurag Tandon +1 more
TL;DR: A combinatorial strategy to efficiently construct LVs using EGFP, hPlk2 wild type (WT) and mutant genes as inserts using BamH I site for the inserts and the amounts and ratios of the insert and vector DNA were optimized to increase monomeric ligation.
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