Journal ArticleDOI
The emergence of optical elastography in biomedicine
TLDR
Optical elastography, the use of optics to characterize and map the mechanical properties of biological tissue, involves measuring the deformation of tissue in response to a load.Abstract:
Optical elastography, the use of optics to characterize and map the mechanical properties of biological tissue, involves measuring the deformation of tissue in response to a load. Such measurements may be used to form an image of a mechanical property, often elastic modulus, with the resulting mechanical contrast complementary to the more familiar optical contrast. Optical elastography is experiencing new impetus in response to developments in the closely related fields of cell mechanics and medical imaging, aided by advances in photonics technology, and through probing the microscale between that of cells and whole tissues. Two techniques — optical coherence elastography and Brillouin microscopy — have recently shown particular promise for medical applications, such as in ophthalmology and oncology, and as new techniques in cell mechanics.read more
Citations
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Proceedings ArticleDOI
Mapping corneal stiffness with compressional optical coherence elastography
TL;DR: The results show the capability of compression-based OCE to measure changes in corneal biomechanical properties in 4 different scenarios (in situ traditional C XL, in situ partial CXL, in vivo traditional CXL and in vivopartial CXL).
Journal ArticleDOI
Stereoscopic Optical Palpation for Tumour Margin Assessment in Breast-Conserving Surgery
Qi-lou Fang,Seok lin Choi,Aiden Taba,Devina D. Lakhiani,Kyle Newman,Renate R. Zilkens,Rowan W. Sanderson,Benjamin F. Dessauvagie,Christobel Saunders,Ben Kennedy +9 more
Book ChapterDOI
Brillouin spectroscopy
TL;DR: In this paper , the authors discuss the development of Brillouin experiments with an insight to its application in the characterization of colloidal nanoparticles and propose a measurement strategy for the acoustic phonons in hypersonic (GHz) frequencies.
Posted ContentDOI
Speckle rheological spectroscopy reveals wideband viscoelastic spectra of biological tissues
TL;DR: In this article , a wideband Speckle rHEologicAl spectRoScopy (SHEARS) was proposed to characterize the viscoelastic properties of tissue in the sub-MHz regime.
Proceedings ArticleDOI
Simultaneous reconstruction and displacement estimation for spectral-domain optical coherence elastography
Jonathan H. Mason,Yvonne Reinwald,Yvonne Reinwald,Ying Yang,Sarah L. Waters,Alicia J. El Haj,Pierre Bagnaninchi +6 more
TL;DR: In this paper, the authors propose a framework for simultaneously enhancing both the image quality and displacement map for elastography, by motion compensated denoising with the block-matching and 4D filtering (BM4D) method, followed by a re-estimation of displacement.
References
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Journal ArticleDOI
Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TL;DR: OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.
Book ChapterDOI
Optical Coherence Tomography
Eric A. Swanson,J. Izatt,M. Bee,David Huang,Charles P. Lin,Carmen A. Puliafito,Carmen A. Puliafito,James G. Fujimoto +7 more
TL;DR: Optical coherence tomography (OCT) has developed rapidly since its first realisation in medicine and is currently an emerging technology in the diagnosis of skin disease as mentioned in this paper, where OCT is an interferometric technique that detects reflected and backscattered light from tissue.
Journal ArticleDOI
Performance of fourier domain vs. time domain optical coherence tomography.
TL;DR: It is shown that FDOCT systems have a large sensitivity advantage and allow for sensitivities well above 80dB, even in situations with low light levels and high speed detection.
Journal ArticleDOI
Shear wave elasticity imaging: a new ultrasonic technology of medical diagnostics
TL;DR: A physical and mathematical basis of SWEI is presented and some experimental results of pilot studies proving feasibility of this new ultrasonic technology are presented, including a theoretical model of shear oscillations in soft biological tissue remotely induced by the radiation force of focused ultrasound.
Journal ArticleDOI
Quantitative assessment on the cloning efficiencies of lentiviral transfer vectors with a unique clone site.
Gang Zhang,Anurag Tandon +1 more
TL;DR: A combinatorial strategy to efficiently construct LVs using EGFP, hPlk2 wild type (WT) and mutant genes as inserts using BamH I site for the inserts and the amounts and ratios of the insert and vector DNA were optimized to increase monomeric ligation.
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