Journal ArticleDOI
The emergence of optical elastography in biomedicine
TLDR
Optical elastography, the use of optics to characterize and map the mechanical properties of biological tissue, involves measuring the deformation of tissue in response to a load.Abstract:
Optical elastography, the use of optics to characterize and map the mechanical properties of biological tissue, involves measuring the deformation of tissue in response to a load. Such measurements may be used to form an image of a mechanical property, often elastic modulus, with the resulting mechanical contrast complementary to the more familiar optical contrast. Optical elastography is experiencing new impetus in response to developments in the closely related fields of cell mechanics and medical imaging, aided by advances in photonics technology, and through probing the microscale between that of cells and whole tissues. Two techniques — optical coherence elastography and Brillouin microscopy — have recently shown particular promise for medical applications, such as in ophthalmology and oncology, and as new techniques in cell mechanics.read more
Citations
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Journal ArticleDOI
Quantifying viscosity and elasticity using holographic imaging by Rayleigh wave dispersion.
TL;DR: In this article , a Rayleigh wave is induced by an electromechanical actuator on the surface of oil-in-gelatin phantoms and a biological tissue sample followed by holographic imaging and reconstruction of the wave.
Journal ArticleDOI
Backward Mach cone of shear waves induced by a moving force in soft anisotropic materials
Guo-Yang Li,Yanping Cao +1 more
TL;DR: In this paper, the elastic Cherenkov effect (ECE) in soft matter was investigated with emphasis on backward Mach cone formation, and phase diagrams were proposed based on the theoretical analysis to elucidate key features of the ECE in a wide material parameter space.
Journal ArticleDOI
Quantitative Micro-Elastography Enables <i>In Vivo</i> Detection of Residual Cancer in the Surgical Cavity during Breast-Conserving Surgery
TL;DR: In this article , a handheld Quantitative Micro-Elastography (QME) probe was designed to detect residual cancer directly in the breast cavity in vivo during breast-conserving surgery (BCS).
Journal ArticleDOI
Pulsatile tissue deformation dynamics of the murine retina and choroid mapped by 4D optical coherence tomography
TL;DR: In this paper , a pixel-wise analysis of phase changes of the complex OCT signal is performed to reveal spatiotemporal displacement characteristics across repeated frame acquisitions, revealing subtle structural deformations related to ocular pulsation.
Journal ArticleDOI
Perspective on non-invasive and non-destructive photoacoustic and photothermal applications
TL;DR: In this article , photoacoustic and photothermal methods offer a unique combination of features that makes them very attractive for exploitation in a wide area of scientific and technological fields that involve material property evaluation.
References
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Journal ArticleDOI
Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TL;DR: OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.
Book ChapterDOI
Optical Coherence Tomography
Eric A. Swanson,J. Izatt,M. Bee,David Huang,Charles P. Lin,Carmen A. Puliafito,Carmen A. Puliafito,James G. Fujimoto +7 more
TL;DR: Optical coherence tomography (OCT) has developed rapidly since its first realisation in medicine and is currently an emerging technology in the diagnosis of skin disease as mentioned in this paper, where OCT is an interferometric technique that detects reflected and backscattered light from tissue.
Journal ArticleDOI
Performance of fourier domain vs. time domain optical coherence tomography.
TL;DR: It is shown that FDOCT systems have a large sensitivity advantage and allow for sensitivities well above 80dB, even in situations with low light levels and high speed detection.
Journal ArticleDOI
Shear wave elasticity imaging: a new ultrasonic technology of medical diagnostics
TL;DR: A physical and mathematical basis of SWEI is presented and some experimental results of pilot studies proving feasibility of this new ultrasonic technology are presented, including a theoretical model of shear oscillations in soft biological tissue remotely induced by the radiation force of focused ultrasound.
Journal ArticleDOI
Quantitative assessment on the cloning efficiencies of lentiviral transfer vectors with a unique clone site.
Gang Zhang,Anurag Tandon +1 more
TL;DR: A combinatorial strategy to efficiently construct LVs using EGFP, hPlk2 wild type (WT) and mutant genes as inserts using BamH I site for the inserts and the amounts and ratios of the insert and vector DNA were optimized to increase monomeric ligation.
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