Journal ArticleDOI
The expression of α-, β-, and γ-synucleins in olfactory mucosa from patients with and without neurodegenerative diseases
TLDR
It is shown here for the first time that α-, β-, and γ-synucleins are differentially expressed in cells of the OE and respiratory epithelium and that α- Synuclein is the most abundant synuclein in the olfactory mucosa, where it is prominently expressed in ORNs.About:
This article is published in Experimental Neurology.The article was published on 1999-12-01. It has received 127 citations till now. The article focuses on the topics: Olfactory epithelium & Olfactory mucosa.read more
Citations
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Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice.
Kelvin C. Luk,Victoria M. Kehm,Bin Zhang,Patrick O’Brien,John Q. Trojanowski,Virginia M.-Y. Lee +5 more
TL;DR: Synthetic a-Synuclein fibrils injected into the brain spread far beyond the injection site and are sufficient to accelerate Parkinson’s disease–like pathology in mice.
Journal ArticleDOI
Parkinson's disease: a dual-hit hypothesis.
TL;DR: It is concluded that the most parsimonious explanation for the initial events of sporadic Parkinson's disease is pathogenic access to the brain through the stomach and nose – hence the term ‘dual‐hit’.
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Olfactory dysfunction in Parkinson disease
TL;DR: Neuroanatomical findings suggest that deficits in cholinergic, noradrenergic and serotonergic function may contribute to the olfactory loss in Parkinson disease.
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Unified Staging System for Lewy Body Disorders: Correlation with Nigrostriatal Degeneration, Cognitive Impairment and Motor Dysfunction
Thomas G. Beach,Charles H. Adler,Lih-Fen Lue,Lucia I. Sue,Jyothi Bachalakuri,Jonette Henry-Watson,Jeanne Sasse,Sarah Boyer,Scophil Shirohi,Reed G Brooks,Jennifer M. Eschbacher,Charles L. White,Haru Akiyama,John N. Caviness,Holly A. Shill,Donald J. Connor,Marwan N. Sabbagh,Douglas G. Walker +17 more
TL;DR: It is suggested that the proposed staging system would improve on its predecessors by allowing classification of a much greater proportion of cases.
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Synucleinopathies: Clinical and Pathological Implications
TL;DR: The synucleinopathies are a diverse group of neurodegenerative disorders that share a common pathologic lesion composed of aggregates of insoluble alpha-synuclein protein in selectively vulnerable populations of neurons and glia, and clarification of this enigmatic symmetry will have a profound impact on understanding the mechanisms underlying all these disorders.
References
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Mutation in the α-synuclein gene identified in families with Parkinson's disease
Mihael H. Polymeropoulos,Christian Lavedan,Elisabeth Leroy,Susan E. Ide,Anindya Dehejia,Amalia Dutra,Brian L. Pike,Holly Root,Jeffrey Rubenstein,Rebecca Boyer,Edward S. Stenroos,Settara C. Chandrasekharappa,Aglaia Athanassiadou,Theodore Papapetropoulos,William G. Johnson,Alice Lazzarini,Roger C. Duvoisin,Giuseppe Di Iorio,Lawrence I. Golbe,Robert L. Nussbaum +19 more
TL;DR: A mutation was identified in the α-synuclein gene, which codes for a presynaptic protein thought to be involved in neuronal plasticity, in the Italian kindred and in three unrelated families of Greek origin with autosomal dominant inheritance for the PD phenotype.
Journal ArticleDOI
Alpha-synuclein in Lewy bodies.
Maria Grazia Spillantini,Marie L. Schmidt,Virginia M.-Y. Lee,John Q. Trojanowski,Ross Jakes,Michel Goedert +5 more
TL;DR: Strong staining of Lewy bodies from idiopathic Parkinson's disease with antibodies for α-synuclein, a presynaptic protein of unknown function which is mutated in some familial cases of the disease, indicates that the LewY bodies from these two diseases may have identical compositions.
Journal ArticleDOI
Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease.
Rejko Krüger,Wilfried Kuhn,Thomas Müller,Dirk Woitalla,Manuel B. Graeber,Sigfried Kösel,Horst Przuntek,Jörg T. Epplen,Ludger Schöls,Olaf Riess +9 more
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α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodies
TL;DR: It is shown thatLewy bodies and Lewy neurites from Parkinson’s disease and dementia with Lewy bodies are stained strongly by antibodies directed against amino- terminal and carboxyl-terminal sequences of α-synuclein, showing the presence of full- length or close to full-length α- synuclein.
Related Papers (5)
Mutation in the α-synuclein gene identified in families with Parkinson's disease
Mihael H. Polymeropoulos,Christian Lavedan,Elisabeth Leroy,Susan E. Ide,Anindya Dehejia,Amalia Dutra,Brian L. Pike,Holly Root,Jeffrey Rubenstein,Rebecca Boyer,Edward S. Stenroos,Settara C. Chandrasekharappa,Aglaia Athanassiadou,Theodore Papapetropoulos,William G. Johnson,Alice Lazzarini,Roger C. Duvoisin,Giuseppe Di Iorio,Lawrence I. Golbe,Robert L. Nussbaum +19 more