Journal ArticleDOI
The flexible use of multiple cue relationships in spatial navigation: a comparison of water maze performance following hippocampal, medial septal, prefrontal cortex, or posterior parietal cortex lesions
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TLDR
The results suggest that the sham-operated control, posterior parietal cortex-lesioned rats, and medial septal area-LESioned rats were able to navigate effectively under changing task conditions and the navigational performances of the prefrontal cortex- and hippocampal formation-lesion rats were impaired when task demands changed.About:
This article is published in Neurobiology of Learning and Memory.The article was published on 1997-09-01. It has received 63 citations till now. The article focuses on the topics: Posterior parietal cortex & Prefrontal cortex.read more
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Essential Role for TrkB Receptors in Hippocampus-Mediated Learning
Liliana Minichiello,Martin Korte,David P. Wolfer,Ralf Kühn,Klaus Unsicker,Vincenzo Cestari,Clelia Rossi-Arnaud,Hans-Peter Lipp,Tobias Bonhoeffer,Rüdiger Klein +9 more
TL;DR: Brain-derived neurotrophic factor and its receptor TrkB regulate both short-term synaptic functions and long-term potentiation (LTP) of brain synapses, raising the possibility that BDNF/TrkB may be involved in cognitive functions.
Journal ArticleDOI
Recovery of brain docosahexaenoate leads to recovery of spatial task performance
Toru Moriguchi,Norman Salem +1 more
TL;DR: The results indicate that animals repleted since birth or at weaning were able to achieve nearly the same level of brain DHA and spatial task performance as animals maintained for three generations on an n‐3 adequate diet.
Journal ArticleDOI
Age-dependent cognitive deficits and neuronal apoptosis in cyclooxygenase-2 transgenic mice
Katrin I. Andreasson,Alena Savonenko,Sveta Vidensky,Joseph J. Goellner,Yan Zhang,Alex Shaffer,Walter E. Kaufmann,Paul F. Worley,Peter C. Isakson,Alicja L. Markowska +9 more
TL;DR: Findings suggest that neuronal COX-2 may contribute to the pathophysiology of age-related diseases such as Alzheimer's disease by promoting memory dysfunction, neuronal apoptosis, and astrocytic activation in an age-dependent manner.
Journal ArticleDOI
Differentiating antidepressants of the future: efficacy and safety.
Sharon Rosenzweig-Lipson,Chad E. Beyer,Zoë A. Hughes,Xavier Z. Khawaja,Somana J. Rajarao,Jessica E. Malberg,Zia Ur Rahman,Robert H. Ring,Lee E. Schechter +8 more
TL;DR: This review will discuss the many facets of differentiation and potential strategies for the development of novel antidepressants, including combination monoaminergic approaches to subtype selective agents to novel targets that include mechanisms to modulate neuropeptides and excitatory amino acids.
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Contingency awareness in human aversive conditioning involves the middle frontal gyrus.
TL;DR: Functional magnetic resonance imaging is used to track the trial-by-trial acquisition of explicit knowledge in a concurrent trace and delay conditioning paradigm and shows that activity in bilateral middle frontal gyrus and parahippocampal gyrus correlates with the accuracy of explicit contingency awareness on each trial.
References
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Book
The Rat Brain in Stereotaxic Coordinates
George Paxinos,Charles Watson +1 more
TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
Journal ArticleDOI
Place navigation impaired in rats with hippocampal lesions.
TL;DR: It is reported that, in addition to a spatial discrimination impairment, total hippocampal lesions also cause a profound and lasting placenavigational impairment that can be dissociated from correlated motor, motivational and reinforcement aspects of the procedure.
Journal ArticleDOI
Spatial Localization Does Not Require the Presence of Local Cues
TL;DR: It is demonstrated that rats can rapidly learn to locate an object that they can never see, hear, or smell provided it remains in a fixed spatial location relative to distal room cues.
Book
Memory, amnesia, and the hippocampal system
Neal J. Cohen,Howard Eichenbaum +1 more
TL;DR: A cognitive neuroscience theory of memory is offered that accounts for the nature of memory impairment exhibited in human amnesia and animal models of amnesia, that specifies the functional role played by the hippocampal system in memory, and that provides further understanding of the componential structure of memory.
Journal ArticleDOI
The cortical projections of the mediodorsal nucleus and adjacent thalamic nuclei in the rat
J. E. Krettek,Joseph L. Price +1 more
TL;DR: The mediodorsal nucleus of the rat thalamus has been divided into medial, central and lateral segments, and these segments have been shown by experiments using the autoradiographic method of demonstrating axonal connections to project to seven distinct cortical areas covering most of the frontal pole of the hemisphere.