Journal ArticleDOI
The genetics of schizophrenia. Current knowledge and future directions.
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TLDR
The multifactorial polygenic model has received the most support and indicates that genetic factors play a greater role than environmental factors in familial transmission and the important implications of genetic-phenotypic heterogeneity and methodological deficiencies are discussed.About:
This article is published in Schizophrenia Research.The article was published on 1991-03-01. It has received 130 citations till now. The article focuses on the topics: Genetic model.read more
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Journal ArticleDOI
Cadherin superfamily genes: functions, genomic organization, and neurologic diversity
Takeshi Yagi,Masatoshi Takeichi +1 more
TL;DR: Findings have interesting implications regarding the molecular events underlying the establishment of complex and organized networks of neuronal connections in the CNS, which may provide further insight into the processes giving rise to diverged brain functions in various species and individuals, as well as the molecular basis of psychociatic diseases.
Book
Search for the Causes of Schizophrenia
Heinz Häfner,Wagner F. Gattaz +1 more
TL;DR: The author revealed that gender differences in age at Onset and Course of Schizophrenic Disorders and the Reverse Genetic approach to the Etiology of Sch schizophrenia offered a clue to the Aetiology of the Disease.
Journal ArticleDOI
Bipolar I Disorder and Schizophrenia: A 440–Single-Nucleotide Polymorphism Screen of 64 Candidate Genes among Ashkenazi Jewish Case-Parent Trios
M. Daniele Fallin,Virginia K. Lasseter,Dimitrios Avramopoulos,Kristin K. Nicodemus,Paula S. Wolyniec,John A. McGrath,Gary Steel,Gerald Nestadt,Kung Yee Liang,Richard L. Huganir,David Valle,Ann E. Pulver +11 more
TL;DR: A single-nucleotide polymorphism genotyping screen of 64 candidate genes chosen on the basis of previous linkage or of association and/or biological relevance provides further support for shared genetic susceptibility between schizophrenia and bipolar disorders that involve glutamate-signaling pathways.
Journal ArticleDOI
Sequential strategy to identify a susceptibility gene for schizophrenia: Report of potential linkage on chromosome 22q12‐q13.1: Part 1
Ann E. Pulver,Maria Karayiorgou,Paula S. Wolyniec,Virginia K. Lasseter,Laura Kasch,Gerald Nestadt,Stylianos E. Antonarakis,David E. Housman,Haig H. Kazazian,Deborah A. Meyers,Jurg Ott,Malgorzata Lamacz,Kung-Yee Liang,John Hanfelt,Gail Ullrich,Nicola DeMarchi,Elango Ramu,Paul R. McHugh,Lawrence Adler,Marion Thomas,William T. Carpenter,Theo C. Manschreck,C. T. Gordon,Michelle L. Kimberland,Robert Babb,Jennifer M. Puck,Barton Childs +26 more
TL;DR: Pairwise linkage analyses suggest a potential linkage for schizophrenia and the hypothesis that schizophrenia is etiologically heterogeneous is tested, which is of sufficient interest to warrant further investigation through collaborative studies.
Journal ArticleDOI
Neurochemical Sensitization in the Pathophysiology of Schizophrenia: Deficits and Dysfunction in Neuronal Regulation and Plasticity
TL;DR: It is proposed that the symptoms of schizophrenia may be caused by deficits in neural regulation resulting in a pathologic condition of neurochemical sensitization analogous to the preclinical model of pharmacologically-induced behavioral sensitization.
References
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Book
Analysis of Human Genetic Linkage
TL;DR: The first and still the only book of its kind, this volume offers a concise introduction to human genetic linkage analysis and gene mapping as discussed by the authors, as well as practical comments on available computer programs and websites.
Journal ArticleDOI
The influence of family and social factors on the course of psychiatric illness. A comparison of schizophrenic and depressed neurotic patients.
Christine Vaughn,Julian Leff +1 more
TL;DR: Important additive effects between various social influences and pharmacological treatments have been revealed which make it possible to predict relapse patterns in schizophrenia with considerable precision.
Journal ArticleDOI
Analysis of Human Genetic Linkage.
A. W. F. Edwards,Jurg Ott +1 more
TL;DR: The first and still the only book of its kind, this volume offers a concise introduction to human genetic linkage analysis and gene mapping and introduces the reader to many of the intricate aspects of complex traits.
Book
Human Genetics: Problems and Approaches
Friedrich Vogel,Arno G. Motulsky +1 more
TL;DR: The history of Human Genetics, Behavioral Genetics, and Genetic Manipulations and the Biological Future of the Human Species are reviewed.