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The immunochemical characterization of the light chains in the mesangial IgA deposits in IgA nephropathy.
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The results indicate that mesangial IgA deposits in IgA nephropathy consist mainly of IgA with lambda light chains despite the fact that the normal ratio of kappa to lambda light-chain-containing immunoglobulin in human serum is two to one.Abstract:
The immunochemical characterization of the light chains of the mesangial immunoglobulin A (IgA) deposits were studied in 45 patients with IgA nephropathy. Kappa and lambda light chains were detected with direct immunofluorescence (IF) method, using monospecific rabbit anti-human anti-kappa and anti-lambda anti-sera. The glomeruli of 42 renal biopsies studied were strongly positive for lambda light chain, while only 25 specimens were positive for kappa light chain. Sixty-five percent of the biopsies showed a predominance of lambda light chain IF staining in the mesangial deposits. This IF pattern is unique as compared with similar studies on renal biopsies from patients with systemic lupus erythematosus, idiopathic membranous nephropathy, and normal postmortem renal tissue. The results indicate that mesangial IgA deposits in IgA nephropathy consist mainly of IgA with lambda light chains despite the fact that the normal ratio of kappa to lambda light-chain-containing immunoglobulin in human serum is two to one.read more
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The Immunohistology of IgA Nephropathy
TL;DR: The glomerular immunohistologic characteristics of 180 patients with IgA nephropathy (IgAN), defined by 2+ or greater mesangial IgA-dominant or codominant immunostaining and no evidence for systemic l upus erythematosus, were compared with those of 84 patients with proliferative lupus glomerulonephritis and 254 patients with other forms of proliferative glomeral disease.
Journal ArticleDOI
Role of Aberrant Glycosylation of IgA1 Molecules in the Pathogenesis of IgA Nephropathy
Jiri Mestecky,Milan Tomana,Zina Moldoveanu,Bruce A. Julian,Hitoshi Suzuki,Karel Matousovic,Matthew B. Renfrow,Lea Novak,Robert J. Wyatt,Jan Novak +9 more
TL;DR: Findings suggest that experimental approaches that prevent the formation of large Gal-deficient IgA1-IgG IC may be applied ultimately in an immunologically mediated therapy.
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IgA-dominant postinfectious glomerulonephritis: a report of 13 cases with common ultrastructural features.
TL;DR: In this paper, the authors describe demographic, clinical, and renal biopsy findings in 13 cases of IgA-dominant postinfectious glomerulonephritis, each characterized by subepithelial humps at various stages of resolution.
Journal ArticleDOI
Increased binding of polymeric λ-IgA to cultured human mesangial cells in IgA nephropathy
TL;DR: The data suggest a preferential mesangial binding of polymeric lambda-IgA1 from patients with IgAN, likely to be "pathogenic" and are important in the pathogenesis of IgAN.
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Journal Article
IgA nephropathy: a syndrome of uniform morphology, diverse clinical features and uncertain prognosis.
TL;DR: While the period of follow-up was too short to assess individual patient data, a gradual and progressive decrease in renal function over several decades is suspected in patients with this condition.
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IgA subclasses in various secretions and in serum.
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A SUBCLASS OF HUMAN γA-GLOBULINS (γA2) WHICH LACKS THE DISULFIDE BONDS LINKING HEAVY AND LIGHT CHAINS
TL;DR: Quantitative analyses indicated higher levels of γA2-proteins in external secretions and the occurrence of two different antigenic types in all normal sera as well as saliva and colostrum that showed the unique interchain disulfide linkage.
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The Clinical Course of Mesangial IgA Associated Nephropathy in Adults
TL;DR: The rate of clinical deterioration correlated with proteinuria, hypertension, impaired renal function, crescents and sclerosed glomeruli on biopsy, and continuing high urinary erythrocyte counts were the strongest predictor of a progressive course.
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The immunochemical characterization of mesangial IgA deposits.
TL;DR: The SC binding capacity of the deposits differed between the groups and was found in 13 of 16 patients with alcoholic liver disease, 3 of 4 with SLE, 1 of 10 with primary IgA nephropathy, and none of 6 with SHP.