Journal ArticleDOI
The impact of child sexual abuse on the course of bipolar disorder: a systematic review
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The impact of child sexual abuse on the course of bipolar disorder: a systematic review and meta-analysis is presented.Abstract:
Maniglio R. The impact of child sexual abuse on the course of bipolar disorder: a systematic review. Bipolar Disord 2013: 00: 000-000. © 2013 John Wiley & Sons A/S.Published by Blackwell Publishing Ltd. Objectives: The aim of this review was to elucidate the impact of child sexual abuse on all clinical phenomena that occur after the onset of bipolar disorder, including associated clinical features that are not part of the diagnostic criteria for the disorder. Methods: Five databases were searched and supplemented with a hand search of reference lists from retrieved papers. Study quality was assessed using a validated quality assessment tool. Blind assessments of study eligibility and quality were conducted by two independent researchers to reduce bias, minimize errors, and enhance the reliability of findings. Disagreements were resolved by consensus. Results: Eighteen studies that included a total of 2996 adults and youths with bipolar disorder and met the minimum quality criteria necessary to ensure objectivity and not invalidate results were analyzed. Across studies, child sexual abuse was strongly (and perhaps directly) associated with posttraumatic stress disorder; whereas it was less strongly (and perhaps indirectly) related to suicide attempts, alcohol and/or drug abuse or dependence, psychotic symptoms, and an early age of illness onset. In regard to the association between child sexual abuse and other clinical variables concerning the course of bipolar disorder, evidence was scant or conflicting. Conclusions: Child sexual abuse is associated (either directly or indirectly) with some clinical phenomena that represent a more severe form of bipolar disorder. Although such a traumatic experience may directly affect the development of posttraumatic stress disorder, the effects of early sexual abuse on later suicidal behavior, substance abuse, and psychotic symptoms may operate through the mediating influences of certain psychopathological or neurobiological variables. Language: enread more
Citations
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The Self-medication Hypothesis of Substance Use Disorders: A Reconsideration and Recent Applications
TL;DR: The self-medication hypothesis of addictive disorders derives primarily from clinical observations of patients with substance use disorders as mentioned in this paper, who discover that the specific actions or effects of each class of drugs relieve or change a range of painful affect states.
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Childhood maltreatment and unfavourable clinical outcomes in bipolar disorder: a systematic review and meta-analysis
TL;DR: Childhood maltreatment predicts unfavourable clinical features and course of illness in patients with bipolar disorder and these associations were not explained by publication bias, undue effects of individual studies, or variation in study quality.
Journal ArticleDOI
Type and timing of adverse childhood experiences differentially affect severity of PTSD, dissociative and depressive symptoms in adult inpatients
Inga Schalinski,Martin H. Teicher,Martin H. Teicher,Daniel Nischk,Eva Hinderer,Oliver Müller,Brigitte Rockstroh +6 more
TL;DR: Results indicate augmented vulnerability by type x timing of ACE, in particular emphasizing pre-school and pre-adolescent periods as sensitive for the impact of physical and emotional neglect.
Journal ArticleDOI
Relationship between childhood adversity and bipolar affective disorder: systematic review and meta-analysis.
TL;DR: Childhood adversity is associated with bipolar disorder, which has implications for the treatment of this clinical group, and further prospective research could clarify temporal causality and explanatory mechanisms.
Journal ArticleDOI
A review of factors associated with greater likelihood of suicide attempts and suicide deaths in bipolar disorder: Part II of a report of the International Society for Bipolar Disorders Task Force on Suicide in Bipolar Disorder
Ayal Schaffer,Erkki Isometsä,Jean-Michel Azorin,Frederick Cassidy,Tina R. Goldstein,Zoltán Rihmer,Mark Sinyor,Leonardo Tondo,Doris Hupfeld Moreno,Gustavo Turecki,Catherine Reis,Lars Vedel Kessing,Kyooseob Ha,Abraham Weizman,Annette L. Beautrais,Yuan-Hwa Chou,Nancy Diazgranados,Anthony J. Levitt,Carlos A. Zarate,Lakshmi N. Yatham +19 more
TL;DR: There is a wealth of data on factors that influence the likelihood of suicide attempts and suicide deaths in people with bipolar disorder, and further research is needed to replicate and determine the magnitude of effect of most of these factors.
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