Open AccessJournal Article
The impact of dopamine on aggression: An [18F]FDOPA PET study
Ingo Vernaleken,Thorben Schlüter,Kai Dautzenberg,Jörn Schmaljohann,Oliver Winz,Felix M. Mottaghy,Gerhard Gruender +6 more
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TLDR
In this article, a modified version of the Point Subtraction Aggression Paradigm (PSAP) was used to measure aggressive behavior during a monetary reward-related paradigm, where a putative adversary habitually tried to cheat.Abstract:
Cerebral dopamine (DA) transmission is thought to be an important modulator for the development and occurrence of aggressive behavior. However, the link between aggression and DA transmission in humans has not been investigated using molecular imaging and standardized behavioral tasks. We investigated aggression as a function of DA transmission in a group of (N = 21) healthy male volunteers undergoing 6-[18F]-fluoro-l-DOPA (FDOPA)-positron emission tomography (PET) and a modified version of the Point Subtraction Aggression Paradigm (PSAP). This task measures aggressive behavior during a monetary reward-related paradigm, where a putative adversary habitually tries to cheat. The participant can react in three ways (i.e., money substraction of the putative opponent [aggressive punishment], pressing a defense button, or continuing his money-making behavior). FDOPA-PET was analyzed using a steady-state model yielding estimates of the DA-synthesis capacity (K), the turnover of tracer DA formed in living brain (kloss), and the tracer distribution volume (Vd), which is an index of DA storage capacity. Significant negative correlations between PSAP aggressive responses and the DA-synthesis capacity were present in several regions, most prominently in the midbrain (r = −0.640; p = 0.002). Lower degrees of aggressive responses were associated with higher DA storage capacity in the striatum and midbrain. Additionally, there was a significant positive correlation between the investment into monetary incentive responses on the PSAP and DA-synthesis capacity, notably in the midbrain (r = +0.618, p = 0.003). The results suggest that individuals with low DA transmission capacity are more vulnerable to reactive/impulsive aggression in response to provocation.read more
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Teens with heavy prenatal cocaine exposure respond to experimental social provocation with escape not aggression
Mark K. Greenwald,Lisa M. Chiodo,John H. Hannigan,Robert J. Sokol,James Janisse,Virginia Delaney-Black +5 more
TL;DR: Data indicate that PCE-teens provoked with a social stressor exhibit a behavioral preference for escape (negative reinforcement) than for aggressive (retaliatory) or appetitive (point- or money-reinforced) responses.
Journal ArticleDOI
Men with high serotonin 1B receptor binding respond to provocations with heightened amygdala reactivity
Sofi da Cunha-Bang,Patrick M. Fisher,Liv V. Hjordt,Erik Perfalk,Vincent Beliveau,Klaus K. Holst,Gitte M. Knudsen,Gitte M. Knudsen +7 more
TL;DR: Novel evidence is provided that 5‐HT1BR levels are linked to amygdala reactivity to provocations in a cohort of men displaying a wide range of aggressive behavior, and 5‐ HT1BR represents an intriguing target for reducing excessive neural reactivityto provocations and thereby putatively violent behavior.
Journal ArticleDOI
Are Owls and Larks Different When it Comes to Aggression? Genetics, Neurobiology, and Behavior.
TL;DR: This review focuses on the contribution of circadian rhythms to aggression with a multifaceted approach incorporating genetics, neural networks, and behavior, and explores the hypothesis that chronic circadian misalignment is contributing to increased aggression.
Journal ArticleDOI
The development of the serotonergic and dopaminergic systems during chicken mid-late embryogenesis
TL;DR: The results raise the possibility that prenatally modulating the 5-HTergic system may lead to long-lasting brain structural and functional alterations during chicken embryogenesis and provide new insights for understanding the functional organization of the5- HTergic system during embryonic development.
Journal ArticleDOI
Imbalance Between Nitric Oxide and Dopamine May Underly Aggression in Acute Neurological Patients
Jesús Ramírez-Bermúdez,Iván Pérez-Neri,Sergio Montes,Marisol Ramirez-Abascal,Francisco Nente,A. Abundes-Corona,José Luis Soto-Hernández,Camilo Ríos +7 more
TL;DR: The relationship between aggressiveness, cognitive performance, and biochemical markers of dopamine neurotransmission and nitric oxide synthesis in cerebrospinal fluid from patients with acute brain disorders, mainly brain infections showed an inverse correlation.