Open AccessJournal Article
The impact of dopamine on aggression: An [18F]FDOPA PET study
Ingo Vernaleken,Thorben Schlüter,Kai Dautzenberg,Jörn Schmaljohann,Oliver Winz,Felix M. Mottaghy,Gerhard Gruender +6 more
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TLDR
In this article, a modified version of the Point Subtraction Aggression Paradigm (PSAP) was used to measure aggressive behavior during a monetary reward-related paradigm, where a putative adversary habitually tried to cheat.Abstract:
Cerebral dopamine (DA) transmission is thought to be an important modulator for the development and occurrence of aggressive behavior. However, the link between aggression and DA transmission in humans has not been investigated using molecular imaging and standardized behavioral tasks. We investigated aggression as a function of DA transmission in a group of (N = 21) healthy male volunteers undergoing 6-[18F]-fluoro-l-DOPA (FDOPA)-positron emission tomography (PET) and a modified version of the Point Subtraction Aggression Paradigm (PSAP). This task measures aggressive behavior during a monetary reward-related paradigm, where a putative adversary habitually tries to cheat. The participant can react in three ways (i.e., money substraction of the putative opponent [aggressive punishment], pressing a defense button, or continuing his money-making behavior). FDOPA-PET was analyzed using a steady-state model yielding estimates of the DA-synthesis capacity (K), the turnover of tracer DA formed in living brain (kloss), and the tracer distribution volume (Vd), which is an index of DA storage capacity. Significant negative correlations between PSAP aggressive responses and the DA-synthesis capacity were present in several regions, most prominently in the midbrain (r = −0.640; p = 0.002). Lower degrees of aggressive responses were associated with higher DA storage capacity in the striatum and midbrain. Additionally, there was a significant positive correlation between the investment into monetary incentive responses on the PSAP and DA-synthesis capacity, notably in the midbrain (r = +0.618, p = 0.003). The results suggest that individuals with low DA transmission capacity are more vulnerable to reactive/impulsive aggression in response to provocation.read more
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References
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Journal ArticleDOI
Dopamine storage capacity in caudate and putamen of patients with early Parkinson's disease: correlation with asymmetry of motor symptoms
TL;DR: The estimates of kloss and EDV2 were more sensitive for the discrimination of biochemical abnormality in the putamen of patients with early PD relative to healthy aged subjects, than was the conventional net influx estimate.
Journal ArticleDOI
Human aggressive responses maintained by avoidance or escape from point loss.
TL;DR: Avoidance contingencies maintained a high rate of aggressive responding over 30 sessions in the absence of point loss, and Escape contingencies also maintained aggressive responding across sessions, with rates of aggressive responses corresponding to rates of point Loss.
Journal ArticleDOI
Pre- and Postsynaptic Serotonergic Differences in Males with Extreme Levels of Impulsive Aggression Without Callous Unemotional Traits: A Positron Emission Tomography Study Using 11C-DASB and 11C-MDL100907
Angela J. Rylands,Rainer Hinz,Matthew Jones,Sophie E. Holmes,M. Feldmann,M. Feldmann,Gavin Brown,Adam McMahon,Peter S. Talbot +8 more
TL;DR: Pre-and postsynaptic 5-HT differences are present in men with high levels of IA and are strongly suggestive of a persisting effect of childhood adversity on serotonergic neurodevelopment and emotional-behavioral control.
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Effects of Smoking Cessation on Presynaptic Dopamine Function of Addicted Male Smokers.
Lena Rademacher,Lena Rademacher,Susanne Prinz,Susanne Prinz,Oliver Winz,Karsten Henkel,Claudia Dietrich,Jörn Schmaljohann,Siamak Mohammadkhani Shali,Ina Schabram,Christian Stoppe,Paul Cumming,Paul Cumming,Ralf-Dieter Hilgers,Yoshitaka Kumakura,Mark Coburn,Felix M. Mottaghy,Felix M. Mottaghy,Gerhard Gründer,Ingo Vernaleken +19 more
TL;DR: In this paper, the authors conducted a PET examination of 30 nicotine-dependent smokers before and after 3 months of abstinence and found that dopamine synthesis capacity was lower in the caudate nuclei of consuming smokers compared with nonsmokers.
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Clock genes, ADHD and aggression
TL;DR: A mechanism by which circadian rhythm and clock gene expression may influence ADHD and comorbid aggression through the modulation of neurotransmitters is proposed.