Perspective: Gestational Tryptophan Fluctuation Altering Neuroembryogenesis and Psychosocial Development
Reads0
Chats0
TLDR
A non-mammal model is developed that provides novel insights for developing appropriate intervention strategies to prevent psychological disorders among individuals, especially those who experienced prenatal stress, by controlling dietary tryptophan and medication therapy during pregnancy.Abstract:
Tryptophan, as the sole precursor of serotonin, mainly derived from diets, is essential for neurodevelopment and immunomodulation. Gestational tryptophan fluctuation may account for the maternal-fetal transmission in determining neuroembryogenesis with long-lasting effects on psychological development. Personality disorders and social exclusion are related to psychosocial problems, leading to impaired social functioning. However, it is not clear how the fluctuation in mother-child transmission regulates the neuroendocrine development and gut microbiota composition in progeny due to that tryptophan metabolism in pregnant women is affected by multiple factors, such as diets (tryptophan-enriched or -depleted diet), emotional mental states (anxiety, depression), health status (hypertension, diabetes), and social support as well as stresses and management skills. Recently, we have developed a non-mammal model to rationalize those discrepancies without maternal effects. This perspective article outlines the possibility and verified the hypothesis in bully-victim research with this novel model: (1). Summarizes the effects of the maternal tryptophan administration on the neuroendocrine and microbial development in their offspring; (2). Highlights the inconsistency and limitations in studying the relationship between gestational tryptophan exposure and psychosocial development in humans and viviparous animals; and (3). Evidences that embryonic exposure to tryptophan and its metabolite modify bullying interactions in the chicken model. With the current pioneer researches on the biomechanisms underlying the bully-victim interaction, the perspective article provides novel insights for developing appropriate intervention strategies to prevent psychological disorders among individuals, especially those who experienced prenatal stress, by controlling dietary tryptophan and medication therapy during pregnancy.read more
Citations
More filters
Journal ArticleDOI
Type I Diabetes Pathoetiology and Pathophysiology: Roles of the Gut Microbiome, Pancreatic Cellular Interactions, and the ‘Bystander’ Activation of Memory CD8+ T Cells
TL;DR: In this article , the importance of alterations in the mitochondrial melatonergic pathway of pancreatic β-cells in driving mitochondrial dysfunction was highlighted, which can act to dysregulate immune responses and systemic mitochondrial function.
Book ChapterDOI
Gestational Tryptophan Fluctuation Underlying Ontogenetic Origin of Neuropsychiatric Disorders
TL;DR: In this article , the authors discuss the risk of personality disorders in offspring and the prevention of personality disorder by dietary tryptophan control and medication therapy management during pregnancy, i.e., exposed to excessive tryptopathophan or its metabolite, serotonin, attenuates aggressiveness and affects peer sociometric status.
References
More filters
Journal ArticleDOI
Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution
LaDeana W. Hillier,Webb Miller,Ewan Birney,Wesley C. Warren,Ross C. Hardison,Chris P. Ponting,Peer Bork,David W. Burt,Martien A. M. Groenen,Mary E. Delany,Jerry B. Dodgson,Asif T. Chinwalla,Paul F. Cliften,Sandra W. Clifton,Kimberly D. Delehaunty,Catrina Fronick,Robert S. Fulton,Tina Graves,Colin Kremitzki,Dan Layman,Vincent Magrini,John Douglas Mcpherson,Tracie L. Miner,Patrick Minx,William E. Nash,Michael N. Nhan,Joanne O. Nelson,Lachlan G. Oddy,Craig Pohl,Jennifer Randall-Maher,Scott M. Smith,John W. Wallis,Shiaw Pyng Yang,Michael N Romanov,Catherine M. Rondelli,Bob Paton,Jacqueline Smith,David Morrice,Laura M. Daniels,Helen G. Tempest,Lindsay Robertson,Julio S. Masabanda,Darren K. Griffin,Alain Vignal,Valerie Fillon,Lina Jacobbson,Susanne Kerje,Leif Andersson,Richard P. M. A. Crooijmans,Jan Aerts,Jan J. van der Poel,Hans Ellegren,Randolph B. Caldwell,Simon J. Hubbard,Darren Grafham,Andrzej M. Kierzek,Stuart McLaren,Ian M. Overton,Hiroshi Arakawa,Kevin J. Beattie,Yuri Bezzubov,Paul E. Boardman,James K. Bonfield,Michael D. R. Croning,Robert L. Davies,Matthew D. Francis,Sean Humphray,Carol Scott,Ruth Taylor,Cheryll Tickle,William Brown,Jane Rogers,Jean-Marie Buerstedde,Stuart A. Wilson,Lisa Stubbs,Ivan Ovcharenko,Laurie Gordon,Susan Lucas,Marcia M. Miller,Hidetoshi Inoko,Takashi Shiina,James C. Kaufman,Jan Salomonsen,Karsten Skjoedt,Gane Ka-Shu Wong,Jun Wang,Bin Liu,Jian Wang,Jun Yu,Huanming Yang,Mikhail Nefedov,Maxim Koriabine,Pieter J. deJong,Leo Goodstadt,Caleb Webber,Nicholas J. Dickens,Ivica Letunic,Mikita Suyama,David Torrents,Christian von Mering,Evgeny M. Zdobnov,Kateryna D. Makova,Anton Nekrutenko,Laura Elnitski,Pallavi Eswara,David C. King,Shan Yang,Svitlana Tyekucheva,Anusha Radakrishnan,Robert S. Harris,Francesca Chiaromonte,James Taylor,Jianbin He,Monique Rijnkels,Sam Griffiths-Jones,Abel Ureta-Vidal,Michael M. Hoffman,Jessica Severin,Stephen M. J. Searle,Andy Law,David Speed,D. Waddington,Ze Cheng,Eray Tüzün,Evan E. Eichler,Zhirong Bao,Paul Flicek,David Shteynberg,Michael R. Brent,Jacqueline M. Bye,Elizabeth J. Huckle,Sourav Chatterji,Colin N. Dewey,Lior Pachter,Andrei Kouranov,Zissimos Mourelatos,Artemis G. Hatzigeorgiou,Andrew H. Paterson,Robert Ivarie,Mikael Brandström,Erik Axelsson,Niclas Backström,Sofia Berlin,Matthew T. Webster,Olivier Pourquié,Alexandre Reymond,Catherine Ucla,Stylianos E. Antonarakis,Manyuan Long,J. J. Emerson,Esther Betrán,Isabelle Dupanloup,Henrik Kaessmann,Angie S. Hinrichs,Gill Bejerano,Terrence S. Furey,Rachel A. Harte,Brian J. Raney,Adam Siepel,W. James Kent,David Haussler,Eduardo Eyras,Robert Castelo,Josep F. Abril,Sergi Castellano,Francisco Camara,Genís Parra,Roderic Guigó,Guillaume Bourque,Glenn Tesler,Pavel A. Pevzner,Arian F.A. Smit,Lucinda Fulton,Elaine R. Mardis,Richard K. Wilson +174 more
TL;DR: A draft genome sequence of the red jungle fowl, Gallus gallus, provides a new perspective on vertebrate genome evolution, while also improving the annotation of mammalian genomes.
Journal ArticleDOI
Prenatal stress and the programming of the HPA axis
TL;DR: There is little evidence, so far, that altered function of the HPA axis in the child mediates the behavioural or cognitive alterations observed to be associated with prenatal stress.
Journal ArticleDOI
A transient placental source of serotonin for the fetal forebrain
Alexandre Bonnin,Nick Goeden,Kevin P. Chen,Melissa L. Wilson,Jennifer King,Jean C. Shih,Randy D. Blakely,Evan S. Deneris,Pat Levitt +8 more
TL;DR: A new, direct role for placental metabolic pathways in modulating fetal brain development is revealed and indicates that maternal–placental–fetal interactions could underlie the pronounced impact of 5-HT on long-lasting mental health outcomes.
Journal ArticleDOI
Prenatal depression effects on early development: A review
TL;DR: This review of recent research on prenatal depression suggests that it is a strong predictor of postpartum depression and is more common than post partum depression.
Journal ArticleDOI
Maternal separation disrupts the integrity of the intestinal microflora in infant rhesus monkeys
TL;DR: The results suggest that strong emotional reactions to disruption of the mother-infant bond may increase vulnerability to disease.