The Jak/STAT pathway.
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TLDR
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway mediates cellular responses to cytokines and growth factors.Abstract:
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway mediates cellular responses to cytokines (e.g., IL-6) and growth factors (e.g., EGF).read more
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Signaling mechanisms controlling cell fate and embryonic patterning.
TL;DR: Examples from Drosophila illustrate their abilities to act either at a short range or over a long distance, and in some instances to generate morphogen gradients that pattern fields of cells in a concentration-dependent manner, and show how feedback loops and transcriptional cascades are part of the logic of developmental regulation.
References
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Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
TL;DR: A previously unrecognized direct signal transduction pathway to the nucleus has been uncovered: IFN-receptor interaction at the cell surface leads to the activation of kinases of the Jak family that phosphorylate substrate proteins called STATs (signal transducers and activators of transcription).
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Janus kinases in immune cell signaling.
TL;DR: existing knowledge on Jak signaling pathways and fundamental work on their biochemical structure and intracellular interactions allow us to develop new strategies for controlling autoimmune diseases or malignancies by developing selective Jak inhibitors, which are now coming into clinical use.
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JAK2 phosphorylates histone H3Y41 and excludes HP1α from chromatin
Mark A. Dawson,Andrew J. Bannister,Berthold Göttgens,Samuel D. Foster,Till Bartke,Anthony R. Green,Tony Kouzarides +6 more
TL;DR: Inhibition of JAK2 activity in human leukaemic cells decreases both the expression of the haematopoietic oncogene lmo2 and the phosphorylation of H3Y41 at its promoter, while simultaneously increasing the binding of HP1α at the same site.
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JAK/STAT signalling in Drosophila: insights into conserved regulatory and cellular functions.
TL;DR: Advances in the field of JAK/STAT signalling are reviewed, focusing on recent developments in Drosophila, to highlight striking levels of physical and functional conservation in processes such as cellular proliferation, immune responses and stem cell maintenance.
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Canonical and non-canonical JAK–STAT signaling
TL;DR: Recent findings in Drosophila have identified a non-canonical mode of JAK-STAT signaling, which directly controls heterochromatin stability, which indicates that the Jak-STAT pathway also controls cellular epigenetic status, which affects expression of genes beyond those under direct STAT transcriptional control.