Journal ArticleDOI
The leucine-rich repeat as a protein recognition motif
Bostjan Kobe,Andrey V. Kajava +1 more
TLDR
New structural information has increased the understanding of the structural determinants of LRR proteins and the ability to model such proteins with unknown structures, and has shed new light on how these proteins participate in protein-protein interactions.About:
This article is published in Current Opinion in Structural Biology.The article was published on 2001-12-01. It has received 1604 citations till now. The article focuses on the topics: Subfamily & Protein structure.read more
Citations
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A Renaissance of Elicitors: Perception of Microbe-Associated Molecular Patterns and Danger Signals by Pattern-Recognition Receptors
Thomas Boller,Georg Felix +1 more
TL;DR: Current evidence indicates that MAMPs, DAMPs, and effectors are all perceived as danger signals and induce a stereotypic defense response, and the importance of MAMP/PRR signaling for plant immunity is highlighted.
Journal ArticleDOI
Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology
Alexander Zimprich,Alexander Zimprich,Saskia Biskup,Petra Leitner,Peter Lichtner,Matthew J. Farrer,Sarah Lincoln,Jennifer M. Kachergus,Mary M. Hulihan,Ryan J. Uitti,Donald B. Calne,A. Jon Stoessl,Ronald F. Pfeiffer,Nadja Patenge,Iria Carballo Carbajal,Peter Vieregge,Friedrich Asmus,Bertram Müller-Myhsok,Dennis W. Dickson,Thomas Meitinger,Tim M. Strom,Zbigniew K. Wszolek,Thomas Gasser +22 more
TL;DR: High-resolution recombination mapping and candidate gene sequencing in 46 families found six disease-segregating mutations in a gene encoding a large, multifunctional protein, LRRK2 (leucine-rich repeat kinase 2), which may be central to the pathogenesis of several major neurodegenerative disorders associated with parkinsonism.
Journal ArticleDOI
Mechanism of auxin perception by the TIR1 ubiquitin ligase
Xu Tan,Luz Irina A. Calderon-Villalobos,Michal Sharon,Changxue Zheng,Carol V. Robinson,Mark Estelle,Ning Zheng +6 more
TL;DR: These structures show that the leucine-rich repeat domain of TIR1 contains an unexpected inositol hexakisphosphate co-factor and recognizes auxin and the Aux/IAA polypeptide substrate through a single surface pocket, establishing the first structural model of a plant hormone receptor.
Journal ArticleDOI
Crystal Structure of the TLR1-TLR2 Heterodimer Induced by Binding of a Tri-Acylated Lipopeptide
Mi Sun Jin,Sung-Eun Kim,Jin Young Heo,Mi Eun Lee,Ho Min Kim,Sang-Gi Paik,Hayyoung Lee,Jie-Oh Lee +7 more
TL;DR: It is proposed that formation of the TLR1-TLR2 heterodimer brings the intracellular TIR domains close to each other to promote dimerization and initiate signaling.
Journal ArticleDOI
Innate immune pattern recognition: a cell biological perspective.
TL;DR: This review highlights aspects of cell biology in pattern-recognition receptor signaling by focusing on signals that originate from the cell surface, from endosomal compartments, and from within the cytosol.
References
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Journal ArticleDOI
The leucine-rich repeat: a versatile binding motif.
Bostjan Kobe,Johann Deisenhofer +1 more
TL;DR: The crystal structure of ribonuclease inhibitor protein has revealed that leucine-rich repeats correspond to beta-alpha structural units, which are arranged so that they form a parallel beta-sheet with one surface exposed to solvent, so that the protein acquires an unusual, nonglobular shape.
Journal ArticleDOI
Nod1, an Apaf-1-like Activator of Caspase-9 and Nuclear Factor-κB
Naohiro Inohara,Takeyoshi Koseki,Luis del Peso,Yuanming Hu,Christina S.K. Yee,Shu Chen,Roberto Carrio,Jesús Merino,Ding Liu,Jian Ni,Gabriel Núñez +10 more
TL;DR: Nod1 is a leucine-rich repeat-containing Apaf-1-like molecule that can regulate both apoptosis and NF-κB activation pathways.
Journal ArticleDOI
Localization of apical epithelial determinants by the basolateral PDZ protein Scribble.
David Bilder,Norbert Perrimon +1 more
TL;DR: The results show that the lateral domain of epithelia, particularly the septate junction, functions in restricting apical membrane identity and correctly placing adherens junctions.
Journal ArticleDOI
A structural basis of the interactions between leucine-rich repeats and protein ligands.
Bostjan Kobe,Johann Deisenhofer +1 more
TL;DR: The unusual non-globular structure of ribonuclease inhibitor, its solvent-exposed parallel β-sheet and the conformational flexibility of the structure are used in the interaction; they appear to be the principal reasons for the effectiveness of leucine-rich repeats as protein-binding motifs.
Journal ArticleDOI
Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats
Bostjan Kobe,Johann Deisenhofer +1 more
TL;DR: This work has determined the crystal structure of the porcine inhibitor, which is the first three-dimensional structure of a protein containing leucine-rich repeats and represents a new class of α/β protein fold.
Related Papers (5)
Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats
Bostjan Kobe,Johann Deisenhofer +1 more
A structural basis of the interactions between leucine-rich repeats and protein ligands.
Bostjan Kobe,Johann Deisenhofer +1 more