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Open AccessJournal ArticleDOI

The Mediterranean Diets: What Is So Special about the Diet of Greece? The Scientific Evidence

Artemis P. Simopoulos
- 01 Nov 2001 - 
- Vol. 131, Iss: 11
TLDR
Analyses of the dietary pattern of the diet of Crete shows a number of protective substances, such as selenium, glutathione, high amounts of fiber, antioxidants, vitamins E and C, some of which have been shown to be associated with lower risk of cancer, including cancer of the breast.
Abstract
The term "Mediterranean diet," implying that all Mediterranean people have the same diet, is a misnomer. The countries around the Mediterranean basin have different diets, religions and cultures. Their diets differ in the amount of total fat, olive oil, type of meat and wine intake; milk vs. cheese; fruits and vegetables; and the rates of coronary heart disease and cancer, with the lower death rates and longer life expectancy occurring in Greece. Extensive studies on the traditional diet of Greece (the diet before 1960) indicate that the dietary pattern of Greeks consists of a high intake of fruits, vegetables (particularly wild plants), nuts and cereals mostly in the form of sourdough bread rather than pasta; more olive oil and olives; less milk but more cheese; more fish; less meat; and moderate amounts of wine, more so than other Mediterranean countries. Analyses of the dietary pattern of the diet of Crete shows a number of protective substances, such as selenium, glutathione, a balanced ratio of (n-6):(n-3) essential fatty acids (EFA), high amounts of fiber, antioxidants (especially resveratrol from wine and polyphenols from olive oil), vitamins E and C, some of which have been shown to be associated with lower risk of cancer, including cancer of the breast. These findings should serve as a strong incentive for the initiation of intervention trials that will test the effect of specific dietary patterns in the prevention and management of patients with cancer.

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Dietary long-chain n−3 fatty acids for the prevention of cancer: a review of potential mechanisms

TL;DR: Several molecular mechanisms whereby n-3 fatty acids may modify the carcinogenic process have been proposed, and influences on transcription factor activity, gene expression, and signal transduction pathways; alteration of estrogen metabolism; increased or decreased production of free radicals and reactive oxygen species; and mechanisms involving insulin sensitivity and membrane fluidity are proposed.
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The possible roles of food-derived bioactive peptides in reducing the risk of cardiovascular disease

TL;DR: By modulating and improving physiological functions, bioactive peptides may provide new therapeutic applications for the prevention or treatment of chronic diseases.
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Tocopherols and total phenolics in 10 different nut types

TL;DR: In this article, a study was conducted to assess the content of tocopherols and carotenoids in unsaponifiable matter as well as the amount of total phenols of 10 different types of nuts.
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Scientific Evidence of Interventions Using the Mediterranean Diet: a Systematic Review

TL;DR: Results disclose the mechanisms of the Mediterranean diet in disease prevention, particularly in cardiovascular disease secondary prevention, but also emphasize the need to undertake experimental research and systematic reviews in the areas of primary prevention of cardiovascular disease, hypertension, diabetes, obesity, infectious diseases, age-related cognitive impairment, and cancer, among others.
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Valuable Nutrients and Functional Bioactives in Different Parts of Olive (Olea europaea L.)—A Review

TL;DR: This review focuses comprehensively on the nutrients and high-value bioactives profile as well as medicinal and functional aspects of different parts of olives and its byproducts.
References
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Journal ArticleDOI

Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes

TL;DR: It is suggested that resveratrol, a common constituent of the human diet, merits investigation as a potential cancer chemopreventive agent in humans.
Journal ArticleDOI

Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial

Roberto Marchioli
- 07 Aug 1999 - 
TL;DR: Dietary supplementation with n-3 PUFA led to a clinically important and statistically significant benefit and vitamin E had no benefit and its effects on fatal cardiovascular events require further exploration.
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Effects of Selenium Supplementation for Cancer Prevention in Patients With Carcinoma of the Skin: A Randomized Controlled Trial

TL;DR: Results from secondary end-point analyses support the hypothesis that supplemental selenium may reduce the incidence of, and mortality from, carcinomas of several sites and require confirmation in an independent trial of appropriate design before new public health recommendations regarding seenium supplementation can be made.
Journal ArticleDOI

Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (dart)

TL;DR: A modest intake of fatty fish (two or three portions per week) may reduce mortality in men who have recovered from MI.
Journal ArticleDOI

Omega-3 fatty acids in health and disease and in growth and development

TL;DR: Omega 3 fatty acids decrease the number and size of tumors and increase the time elapsed before appearance of tumors, which is essential for the normal functional development of the retina and brain, particularly in premature infants.
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