Open AccessDOI
The microenvironment of brain metastases from solid tumors.
Ethan S Srinivasan,Krutika Deshpande,Josh Neman,Frank Winkler,Frank Winkler,Mustafa Khasraw +5 more
- Vol. 3
TLDR
In this paper, the authors discuss unique aspects of the TME in the context of brain metastases and pathways through which they may hold the key to the discovery of new and effective therapies for patients with brain metastasis.Abstract:
Brain metastasis (BrM) is an area of unmet medical need that poses unique therapeutic challenges and heralds a dismal prognosis. The intracranial tumor microenvironment (TME) presents several challenges, including the therapy-resistant blood-brain barrier, a unique immune milieu, distinct intercellular interactions, and specific metabolic conditions, that are responsible for treatment failures and poor clinical outcomes. There is a complex interplay between malignant cells that metastasize to the central nervous system (CNS) and the native TME. Cancer cells take advantage of vascular, neuronal, immune, and anatomical vulnerabilities to proliferate with mechanisms specific to the CNS. In this review, we discuss unique aspects of the TME in the context of brain metastases and pathways through which the TME may hold the key to the discovery of new and effective therapies for patients with BrM.read more
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Journal ArticleDOI
The spatial transcriptomic landscape of non-small cell lung cancer brain metastasis
Qi Zhang,R. Abdo,Cristiana Iosef,Tomonori Kaneko,Matthew J. Cecchini,Victor Km Han,Shawn S.-C. Li +6 more
TL;DR: In this paper , the authors analyzed primary and metastasized tumor specimens from 44 non-small cell lung cancer patients by spatial RNA sequencing, affording a whole transcriptome map of metastasis resolved with morphological markers for the tumor core, tumor immune microenvironment (TIME), and tumor brain micro environment (TBME).
Journal ArticleDOI
The Tumor Microenvironment of Medulloblastoma: An Intricate Multicellular Network with Therapeutic Potential
TL;DR: In this article , the authors discuss all the different components of the MB TME and their role in MB initiation, progression, metastasis, and relapse, and highlight the TME-directed treatments, in which they focus on therapies that are being evaluated in clinical trials.
Journal ArticleDOI
Advances in the Molecular Landscape of Lung Cancer Brain Metastasis
Vanessa G P Souza,Rachel Paes De Araújo,Mariana R. Santesso,Ana L Seneda,Iael W Minutentag,Tainara F. Felix,Pedro Tadao Hamamoto Filho,Michelle E Pewarchuk,Liam J. Brockley,Fabio Albuquerque Marchi,Wan L. Lam,Sandra A. Drigo,Patricia P Reis +12 more
TL;DR: In this article , the authors comprehensively describe the major steps of metastatic spread of lung cancer to the brain, addressing the influence of the tumor microenvironment and the molecular determinants of progression.
Journal ArticleDOI
Tumor microenvironment and exosomes in brain metastasis: Molecular mechanisms and clinical application
Yirizhati Aili,N. E. M. M. T. Maimaitiming,Huamin Qin,Wenyu Ji,Guo-Guang Fan,Zengliang Wang,Yongxin Wang +6 more
TL;DR: The roles and prospects of brain metastatic tumor cells, the brain metastic tumor microenvironment, and exosomes in the development and clinical management ofbrain metastases are reviewed.
Journal ArticleDOI
A vision of 14 T MR for fundamental and clinical science
Serge O. Dumoulin,Paul J. M. Folkers,Elia Formisano,Rainer Goebel,Rick C. Helmich,Dennis W. J. Klomp,Anja G. van der Kolk,Aart J. Nederveen,David G. Norris,Natalia Petridou,Stefan Roell,Tom W. J. Scheenen,Menno M. Schoonheim,Ingmar J. Voogt,Andrew G. Webb +14 more
TL;DR: In this paper , the authors outline the vision for a 14 Tesla MR system, which comprises a whole-body magnet design utilizing high temperature superconductor; a console and associated electronic equipment; an optimized radiofrequency coil setup for proton measurement in the brain, which also has a local shim capability; and a high-performance gradient set.
References
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