Journal ArticleDOI
The monosodium iodoacetate model of osteoarthritis: a model of chronic nociceptive pain in rats?
TLDR
The MIA model of OA is reproducible and mimics OA pain in humans, and analgesic drug studies indicate this model may be useful for investigating chronic nociceptive pain.About:
This article is published in Neuroscience Letters.The article was published on 2004-11-11. It has received 213 citations till now. The article focuses on the topics: Allodynia & Chronic pain.read more
Citations
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Journal ArticleDOI
Models and Mechanisms of Hyperalgesia and Allodynia
TL;DR: This review focuses on highly topical spinal mechanisms of hyperalgesia and allodynia including intrinsic and synaptic plasticity, the modulation of inhibitory control, and neuroimmune interactions.
Journal ArticleDOI
Structural pathology in a rodent model of osteoarthritis is associated with neuropathic pain: Increased expression of ATF-3 and pharmacological characterisation
Stefan P. Ivanavicius,Adrian D. Ball,Chris G. Heapy,F. Russell Westwood,Fraser Murray,Simon Read +5 more
TL;DR: Data suggest that this putative model of OA is associated with an early phase neuropathy in the L5 innervation territory of the knee.
Journal ArticleDOI
Pain-related sensory innervation in monoiodoacetate-induced osteoarthritis in rat knees that gradually develops neuronal injury in addition to inflammatory pain.
Sumihisa Orita,Tetsuhiro Ishikawa,Masayuki Miyagi,Nobuyasu Ochiai,Gen Inoue,Yawara Eguchi,Hiroto Kamoda,Gen Arai,Tomoaki Toyone,Yasuchika Aoki,Takekazu Kubo,Kazuhisa Takahashi,Seiji Ohtori +12 more
TL;DR: Pain-related characteristics in a MIA-induced rat OA model can originate from an inflammatory pain state induced by the local inflammation initiated by inflammatory cytokines, and that state will be followed by gradual initiation of neuronal injury, which may induce the neuropathic pain state.
Journal ArticleDOI
Techniques for assessing knee joint pain in arthritis
TL;DR: This review will focus on knee joint pain associated with arthritis and a discussion of pain assessment in humans with arthritis pain conditions.
Journal ArticleDOI
Alteration of sensory neurons and spinal response to an experimental osteoarthritis pain model.
Hee Jeong Im,Jae-Sung Kim,Xin Li,Naomi Kotwal,Dale R. Sumner,Andre J. Van Wijnen,Francesca J. Davis,Dongyao Yan,Brett R. Levine,James L. Henry,Jacques Desevré,Jeffrey S. Kroin +11 more
TL;DR: The results indicate that MIA-induced joint degeneration in rats generates an animal model that is suitable for mechanistic and pharmacologic studies on nociceptive pain pathways caused by OA, and provide key in vivo evidence that OA pain is caused by central sensitization through communication between peripheral OA nocICEptors and the central sensory system.
References
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Journal ArticleDOI
Ethical guidelines for investigations of experimental pain in conscious animals.
TL;DR: The Committee for Research and Ethical Issues of the International Association for the Study of Pain (IASP®) is concerned with the ethical aspects of studies producing experimental pain and any suffering it may cause in animals.
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A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man.
Gary J. Bennett,Y.-K. Xie +1 more
TL;DR: A peripheral mononeuropathy was produced in adult rats by placing loosely constrictive ligatures around the common sciatic nerve and the postoperative behavior of these rats indicated that hyperalgesia, allodynia and, possibly, spontaneous pain were produced.
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Neuronal plasticity: increasing the gain in pain.
TL;DR: Here, a conceptual framework for the contribution of plasticity in primary sensory and dorsal horn neurons to the pathogenesis of pain is developed, identifying distinct forms of Plasticity, which are term activation, modulation, and modification, that by increasing gain, elicit pain hypersensitivity.
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Weight bearing as a measure of disease progression and efficacy of anti-inflammatory compounds in a model of monosodium iodoacetate-induced osteoarthritis
Susan E. Bove,Susan L. Calcaterra,Rachel M. Brooker,C.M Huber,Roberto E. Guzman,P.L. Juneau,D.J Schrier,Kenneth S. Kilgore +7 more
TL;DR: The determination of differences in hind paw weight distribution in the rat MIA model of OA is a technically straightforward, reproducible method that is predictive of the effects of anti-inflammatory and analgesic agents and useful for the discovery of novel pharmacologic agents in human OA.
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Mono‐iodoacetate‐induced experimental osteoarthritis. A dose‐response study of loss of mobility, morphology, and biochemistry
Corinne Guingamp,Pascale Gegout-Pottie,Lionel Philippe,Bernard Terlain,Patrick Netter,Pierre Gillet +5 more
TL;DR: When a sufficient dose of MIA is used, this model can easily and quickly reproduce OA-like lesions and functional impairment in rats, similar to that observed in human disease.