The Nature of Immune Responses to Influenza Vaccination in High-Risk Populations.
TLDR
In this article, the authors investigated the variations in immune responses to influenza vaccination in high-risk populations, including the elderly, people with obesity, and individuals with comorbidities such as type 2 diabetes mellitus.Abstract:
The current pandemic has brought a renewed appreciation for the critical importance of vaccines for the promotion of both individual and public health. Influenza vaccines have been our primary tool for infection control to prevent seasonal epidemics and pandemics such as the 2009 H1N1 influenza A virus pandemic. Certain high-risk populations, including the elderly, people with obesity, and individuals with comorbidities such as type 2 diabetes mellitus, are more susceptible to increased disease severity and decreased vaccine efficacy. High-risk populations have unique microenvironments and immune responses that contribute to increased vulnerability for influenza infections. This review focuses on these differences as we investigate the variations in immune responses to influenza vaccination. In order to develop better influenza vaccines, it is critical to understand how to improve responses in our ever-growing high-risk populations.read more
Citations
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Influenza vaccine improves cardiovascular outcomes in patients with coronary artery disease: A systematic review and meta-analysis.
TL;DR: In this article , the authors evaluated the effect of the influenza vaccine on cardiovascular outcomes in patients with coronary artery disease (CAD) and found that the vaccine significantly reduced the risk of major adverse cardiovascular events (MACE), all-cause mortality, and cardiovascular mortality.
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Antiviral Approaches against Influenza Virus
Rashmi Kumari,Suresh D. Sharma,Amrita Raja Vinoda Kumar,Zachary Ende,Margarita Mishina,Yuanyuan Wang,Zackary Falls,Ram Samudrala,Jan Pohl,Paul R. Knight,Suryaprakash Sambhara +10 more
TL;DR: A review of FDA-approved influenza antivirals with their mechanisms of action, and different viral-and host-directed influenza antiviral approaches, including immunomodulatory interventions in clinical development is presented in this article .
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How Comorbidities Affect Hospitalization from Influenza in the Pediatric Population
Sophia C Mylonakis,Evangelia K. Mylona,Markos Kalligeros,Fadi Shehadeh,Philip A. Chan,Eleftherios Mylonakis +5 more
TL;DR: Specific comorbidities associated with influenza hospitalization and length of hospital stay are identified, and these groups should be prioritized for public health interventions.
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Role of Acacia catechu and Scutellaria baicalensis in Enhancing Immune Function Following Influenza Vaccination of Healthy Adults: A Randomized, Triple-Blind, Placebo-Controlled Clinical Trial.
TL;DR: In this article , the role of an Acacia catechu and Scutellaria baicalensis formulation, UP446, on supporting immune function in response to influenza vaccination was examined.
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Difference in survival between COPD patients with an impaired immune reaction versus an adequate immune reaction to seasonal influenza vaccination: The COMIC study.
Marjolein Brusse-Keizer,Emanuel Citgez,Maaike Zuur-Telgen,Huib A. M. Kerstjens,G.T. Rijkers,Paul VanderValk,J. van der Palen +6 more
TL;DR: In this article , the authors found that COPD patients who do not achieve seroprotective levels after influenza vaccination, are a less immune-competent group with a higher risk of morbidity and mortality.
References
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Maternal vitamin D deficiency increases the risk of obesity in male offspring mice by affecting the immune response
Pei Li,Ping Li,Liu Yuanlin,Liu Weijiang,Lanlan Zha,Xiaoyu Chen,Rongxiu Zheng,Kemin Qi,Yi Zhang +8 more
TL;DR: Maternal VD deficiency might promote the development of obesity in male offspring mice partly by modulating the immune cell populations and causing a polarization in the adipose depots.
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