The Nature of Immune Responses to Influenza Vaccination in High-Risk Populations.
TLDR
In this article, the authors investigated the variations in immune responses to influenza vaccination in high-risk populations, including the elderly, people with obesity, and individuals with comorbidities such as type 2 diabetes mellitus.Abstract:
The current pandemic has brought a renewed appreciation for the critical importance of vaccines for the promotion of both individual and public health. Influenza vaccines have been our primary tool for infection control to prevent seasonal epidemics and pandemics such as the 2009 H1N1 influenza A virus pandemic. Certain high-risk populations, including the elderly, people with obesity, and individuals with comorbidities such as type 2 diabetes mellitus, are more susceptible to increased disease severity and decreased vaccine efficacy. High-risk populations have unique microenvironments and immune responses that contribute to increased vulnerability for influenza infections. This review focuses on these differences as we investigate the variations in immune responses to influenza vaccination. In order to develop better influenza vaccines, it is critical to understand how to improve responses in our ever-growing high-risk populations.read more
Citations
More filters
Journal ArticleDOI
Influenza vaccine improves cardiovascular outcomes in patients with coronary artery disease: A systematic review and meta-analysis.
TL;DR: In this article , the authors evaluated the effect of the influenza vaccine on cardiovascular outcomes in patients with coronary artery disease (CAD) and found that the vaccine significantly reduced the risk of major adverse cardiovascular events (MACE), all-cause mortality, and cardiovascular mortality.
Journal ArticleDOI
Antiviral Approaches against Influenza Virus
Rashmi Kumari,Suresh D. Sharma,Amrita Raja Vinoda Kumar,Zachary Ende,Margarita Mishina,Yuanyuan Wang,Zackary Falls,Ram Samudrala,Jan Pohl,Paul R. Knight,Suryaprakash Sambhara +10 more
TL;DR: A review of FDA-approved influenza antivirals with their mechanisms of action, and different viral-and host-directed influenza antiviral approaches, including immunomodulatory interventions in clinical development is presented in this article .
Journal ArticleDOI
How Comorbidities Affect Hospitalization from Influenza in the Pediatric Population
Sophia C Mylonakis,Evangelia K. Mylona,Markos Kalligeros,Fadi Shehadeh,Philip A. Chan,Eleftherios Mylonakis +5 more
TL;DR: Specific comorbidities associated with influenza hospitalization and length of hospital stay are identified, and these groups should be prioritized for public health interventions.
Journal ArticleDOI
Role of Acacia catechu and Scutellaria baicalensis in Enhancing Immune Function Following Influenza Vaccination of Healthy Adults: A Randomized, Triple-Blind, Placebo-Controlled Clinical Trial.
TL;DR: In this article , the role of an Acacia catechu and Scutellaria baicalensis formulation, UP446, on supporting immune function in response to influenza vaccination was examined.
Journal ArticleDOI
Difference in survival between COPD patients with an impaired immune reaction versus an adequate immune reaction to seasonal influenza vaccination: The COMIC study.
Marjolein Brusse-Keizer,Emanuel Citgez,Maaike Zuur-Telgen,Huib A. M. Kerstjens,G.T. Rijkers,Paul VanderValk,J. van der Palen +6 more
TL;DR: In this article , the authors found that COPD patients who do not achieve seroprotective levels after influenza vaccination, are a less immune-competent group with a higher risk of morbidity and mortality.
References
More filters
Journal ArticleDOI
COVID-19 and Vaccine Hesitancy: A Challenge the United States Must Overcome.
TL;DR: Experience from the influenza vaccines have shown vaccine acceptance has not been optimal, and this new vaccine, even though it is not approved, is already showing layperson skepticism compounded by political influences.
Journal ArticleDOI
Inflammation of brown/beige adipose tissues in obesity and metabolic disease
TL;DR: The targeting of brown and beige adipose tissues by pro‐inflammatory signals and the subsequent impairment of their thermogenic and metabolite draining activities appears to represent obesity‐driven disturbances that contribute to metabolic syndrome and cardiovascular alterations in obesity.
Journal ArticleDOI
Vitamin A signaling and homeostasis in obesity, diabetes, and metabolic disorders.
TL;DR: The primary focus of the review will be on the effects that vitamin A per se and proteins involved in vitamin A metabolism have on adipocytes, adipose tissue biology, and adipose-related disease, as well as on early stage liver disease, including non-alcoholic fatty liver disease (NAFLD and non- alcoholic steatohepatitis (NASH).
Journal ArticleDOI
Anti-HA Glycoforms Drive B Cell Affinity Selection and Determine Influenza Vaccine Efficacy
Taia T. Wang,Jad Maamary,Gene S. Tan,Stylianos Bournazos,Carl W. Davis,Florian Krammer,Sarah J. Schlesinger,Peter Palese,Rafi Ahmed,Jeffrey V. Ravetch +9 more
TL;DR: It is shown that sFcs drive BCR affinity selection by binding the Type-II FcR CD23, thus upregulating the inhibitory FcγRIIB on activated B cells, resulting in B cell selection for higher affinity BCR.
Journal ArticleDOI
Overweight and obese adult humans have a defective cellular immune response to pandemic H1N1 Influenza a virus
Heather A. Paich,Patricia A. Sheridan,Jean Handy,Erik A. Karlsson,Stacey Schultz-Cherry,Michael G. Hudgens,Terry L. Noah,Samuel S. Weir,Melinda A. Beck +8 more
TL;DR: The objective of the present study was to elucidate the specific mechanisms by which obesity and overweight impact the cellular immune response to pH1N1.
Related Papers (5)
Host Factors Impact Vaccine Efficacy: Implications for Seasonal and Universal Influenza Vaccine Programs.
Santosh Dhakal,Sabra L. Klein +1 more