The Nature of Immune Responses to Influenza Vaccination in High-Risk Populations.
TLDR
In this article, the authors investigated the variations in immune responses to influenza vaccination in high-risk populations, including the elderly, people with obesity, and individuals with comorbidities such as type 2 diabetes mellitus.Abstract:
The current pandemic has brought a renewed appreciation for the critical importance of vaccines for the promotion of both individual and public health. Influenza vaccines have been our primary tool for infection control to prevent seasonal epidemics and pandemics such as the 2009 H1N1 influenza A virus pandemic. Certain high-risk populations, including the elderly, people with obesity, and individuals with comorbidities such as type 2 diabetes mellitus, are more susceptible to increased disease severity and decreased vaccine efficacy. High-risk populations have unique microenvironments and immune responses that contribute to increased vulnerability for influenza infections. This review focuses on these differences as we investigate the variations in immune responses to influenza vaccination. In order to develop better influenza vaccines, it is critical to understand how to improve responses in our ever-growing high-risk populations.read more
Citations
More filters
Journal ArticleDOI
Influenza vaccine improves cardiovascular outcomes in patients with coronary artery disease: A systematic review and meta-analysis.
TL;DR: In this article , the authors evaluated the effect of the influenza vaccine on cardiovascular outcomes in patients with coronary artery disease (CAD) and found that the vaccine significantly reduced the risk of major adverse cardiovascular events (MACE), all-cause mortality, and cardiovascular mortality.
Journal ArticleDOI
Antiviral Approaches against Influenza Virus
Rashmi Kumari,Suresh D. Sharma,Amrita Raja Vinoda Kumar,Zachary Ende,Margarita Mishina,Yuanyuan Wang,Zackary Falls,Ram Samudrala,Jan Pohl,Paul R. Knight,Suryaprakash Sambhara +10 more
TL;DR: A review of FDA-approved influenza antivirals with their mechanisms of action, and different viral-and host-directed influenza antiviral approaches, including immunomodulatory interventions in clinical development is presented in this article .
Journal ArticleDOI
How Comorbidities Affect Hospitalization from Influenza in the Pediatric Population
Sophia C Mylonakis,Evangelia K. Mylona,Markos Kalligeros,Fadi Shehadeh,Philip A. Chan,Eleftherios Mylonakis +5 more
TL;DR: Specific comorbidities associated with influenza hospitalization and length of hospital stay are identified, and these groups should be prioritized for public health interventions.
Journal ArticleDOI
Role of Acacia catechu and Scutellaria baicalensis in Enhancing Immune Function Following Influenza Vaccination of Healthy Adults: A Randomized, Triple-Blind, Placebo-Controlled Clinical Trial.
TL;DR: In this article , the role of an Acacia catechu and Scutellaria baicalensis formulation, UP446, on supporting immune function in response to influenza vaccination was examined.
Journal ArticleDOI
Difference in survival between COPD patients with an impaired immune reaction versus an adequate immune reaction to seasonal influenza vaccination: The COMIC study.
Marjolein Brusse-Keizer,Emanuel Citgez,Maaike Zuur-Telgen,Huib A. M. Kerstjens,G.T. Rijkers,Paul VanderValk,J. van der Palen +6 more
TL;DR: In this article , the authors found that COPD patients who do not achieve seroprotective levels after influenza vaccination, are a less immune-competent group with a higher risk of morbidity and mortality.
References
More filters
Journal ArticleDOI
Glycemic Variability in Diabetes Increases the Severity of Influenza
Rebecca J. Marshall,Pornthida Armart,Katina D. Hulme,Keng Yih Chew,Alexandra C. Brown,Philip M. Hansbro,Conor J. Bloxham,Melanie Flint,Katharina Ronacher,Helle Bielefeldt-Ohmann,Linda A. Gallo,Kirsty R. Short +11 more
TL;DR: An in vitro model of the pulmonary epithelial-endothelial barrier and novel murine models are used to investigate the role of glycemic variability in influenza severity and provide the first indication that gly glucose variability may help drive the increased risk of severe influenza in people with diabetes mellitus.
Journal ArticleDOI
Past Life and Future Effects-How Heterologous Infections Alter Immunity to Influenza Viruses.
Aisha Souquette,Paul G. Thomas +1 more
TL;DR: Recent advances in understanding the effects of heterologous infections on the establishment and maintenance of CD8+ T cell immunological memory are discussed.
Journal ArticleDOI
The evaluation of immune responses to hepatitis B vaccination in diabetic and non-diabetic haemodialysis patients and the use of tetanus toxoid.
TL;DR: Whether haemodialysis patients suffering from diabetes mellitus could be considered at risk for the development of the protective antibodies to hepatitis B vaccination and, to evaluate the effectiveness of tetanus toxoid (TT) administrated 2 days before HB vaccination.
Journal ArticleDOI
US healthcare costs attributable to type A and type B influenza.
TL;DR: Estimating numbers of healthcare encounters and healthcare costs attributable to influenza viral strains A and B in the US during the 2001/2002 – 2008/2009 seasons found that type B strains accounted for 37% of healthcare costs across all seasons, and as much as 66% in a single season.
Journal ArticleDOI
Immunological responses to influenza vaccination: lessons for improving vaccine efficacy.
TL;DR: A pathway that is critical for modulating the breadth and potency of anti-HA antibody responses and has previously led to the development of strategies to improve influenza vaccine efficacy is discussed.
Related Papers (5)
Host Factors Impact Vaccine Efficacy: Implications for Seasonal and Universal Influenza Vaccine Programs.
Santosh Dhakal,Sabra L. Klein +1 more