The regulation of spermatogenesis by androgens.
Lee B. Smith,William H. Walker +1 more
TLDR
The functional information that has been obtained from the knock out of the androgen receptor from specific cell types in the testis and the genes found to be regulated after altering testosterone levels or androgens receptor expression are reviewed.About:
This article is published in Seminars in Cell & Developmental Biology.The article was published on 2014-06-01 and is currently open access. It has received 511 citations till now. The article focuses on the topics: Androgen receptor & Testosterone.read more
Citations
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The Mammalian Blood-Testis Barrier: Its Biology and Regulation
Dolores D. Mruk,C. Yan Cheng +1 more
TL;DR: The biology and regulation of the mammalian blood-testis barrier is reviewed and research areas that should be expanded in future studies are highlighted to create a unique microenvironment for the completion of meiosis and the subsequent development of spermatids into spermatozoa via spermiogenesis.
Journal ArticleDOI
A Comprehensive Roadmap of Murine Spermatogenesis Defined by Single-Cell RNA-Seq.
Christopher D. Green,Qianyi Ma,Gabriel L. Manske,Adrienne Niederriter Shami,Xianing Zheng,Simone Marini,Lindsay Moritz,Caleb Sultan,Stephen J. Gurczynski,Bethany B. Moore,Michelle D. Tallquist,Jun Li,Saher Sue Hammoud +12 more
TL;DR: High-resolution single-cell RNA sequencing data was collected from ∼35,000 cells from the adult mouse testis and identified all known germ and somatic cells, as well as two unexpected somatic cell types, representing a community resource and foundation of knowledge to study germ cell development and in vivo gametogenesis.
Journal ArticleDOI
Endocrine control of spermatogenesis: Role of FSH and LH/ testosterone.
TL;DR: The histological sequelae of disturbed reproductive endocrinology in rat, dog and nonhuman primates and a review of the current understanding of the roles of gonadotropins and androgens are focused on.
Journal ArticleDOI
The Sertoli cell: one hundred fifty years of beauty and plasticity.
Luiz R. França,Luiz R. França,Rex A. Hess,Jannette M. Dufour,Marie Claude Hofmann,Michael D. Griswold +5 more
TL;DR: This review examines the three phases of morphological research that have occurred in the study of Sertoli cells, because microscopic anatomy was essentially the only scientific discipline available for about the first 75 years after the discovery of the testicular ‘nurse cell’.
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Macrophages Contribute to the Spermatogonial Niche in the Adult Testis.
TL;DR: It is shown that transient depletion of macrophages leads to a disruption in spermatogonial differentiation and raises the possibility that macrophage play previously unappreciated roles in stem/progenitor cell regulation in other tissues.
References
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Molecular mechanisms of action of steroid/thyroid receptor superfamily members
Ming-Jer Tsai,Bert W. O'Malley +1 more
TL;DR: The role of Ligand in RECEPTOR TRANSFORMATION and ACTIVATION is studied, as well as the role of serotonin, which plays a role in both transformation and inhibition.
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Sertoli-Sertoli and Sertoli-Germ Cell Interactions and Their Significance in Germ Cell Movement in the Seminiferous Epithelium during Spermatogenesis
Dolores D. Mruk,C. Yan Cheng +1 more
TL;DR: This review focuses on the process by which a single spermatogonium develops into 256 spermatozoa, one of which will fertilize the ovum, and recaps recent developments in the field.
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Cell-type-specific isolation of ribosome-associated mRNA from complex tissues
TL;DR: A strategy to rapidly and efficiently isolate ribosome-associated mRNA transcripts from any cell type in vivo is described and the application of this technique is demonstrated in brain using neuron-specific Cre recombinase-expressing mice and in testis using a Sertoli cell Cre recomb inase- expressing mouse.
Journal ArticleDOI
A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis.
Karel De Gendt,Johannes V. Swinnen,Philippa T. K. Saunders,Luc Schoonjans,Mieke Dewerchin,Ann Devos,Karen Tan,Nina Atanassova,Frank Claessens,Charlotte Lécureuil,Walter Heyns,Peter Carmeliet,Florian Guillou,Richard M. Sharpe,Guido Verhoeven +14 more
TL;DR: It is concluded that cell-autonomous action of the AR in SC is an absolute requirement for androgen maintenance of complete spermatogenesis, and that sPermatocyte/spermatid development/survival critically depends on androgens.